JAMA Network Open
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JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMANetworkOpen.com
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RCT: Web-based guided self-help was noninferior to usual treatment in reducing binge-eating episodes in binge eating disorder at both the end of treatment and at 20 weeks after treatment. ja.ma/4q6daMe
JAMA Network graphic comparing web-based guided self-help to treatment as usual for binge eating disorder. The study included 160 women and 27 men. A bar graph shows mean binge eating episodes at end-of-treatment and 20 weeks post-treatment.
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In this secondary analysis of an RCT, respiratory viral exposures were high; HEPA purifiers were not associated with an overall reduction in viral burden but did reduce the number of different viruses found. ja.ma/46ZyLgv
JAMA Network Open study on air purifiers in 200 elementary classrooms. It shows 91 sham and 109 HEPA purifiers were tested. The graph compares viral exposure with both, noting similar odds between the two.
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Patients undergoing extracranial surgery early after TBI, or with acute CT brain findings, had worse cognitive & disability outcomes compared with general orthopedic trauma patients or those with TBI with negative head CTs.

#ANES25

ja.ma/4o8iZqA
Two stacked bar graphs compare GOSE outcomes for TBI patients with/without surgery across injury groups. The top graph (GOSE-TBI) and bottom graph (GOSE-all) show percentages of participants in categories from death to upper good recovery.
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RCT: Adolescents in school uniforms were less successful at purchasing e-cigarettes than those wearing casual attire, were more likely to be asked about their age, requested to show ID, and dissuaded from using e-cigarettes. ja.ma/4niM2qR
Infographic titled "E-Cigarette Sales to School-Uniformed Adolescents in China." It shows that adolescents in school uniforms were less likely to purchase e-cigarettes (65.0%) than those in casual attire (91.8%).
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In patients with idiopathic recurrent #pericarditis, IL-1ra-abs were exclusively detected in patients with active recurrent pericarditis, suggesting transient IL-1ra autoimmunity is a feature of active recurrent pericarditis. ja.ma/3KHHOLx
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#Medicaid patients face barriers scheduling outpatient referral visits even when accounting for other factors impacting access, particularly those not in a specific health system’s ACO. ja.ma/48mXhdR
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Numerous and specialty-specific barriers hinder first-line treatment intensification for metastatic castration-sensitive prostate #cancer, and cross-specialty tumor boards are a promising solution to improve its uptake. ja.ma/46YXJfQ
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In this economic evaluation of medically attended #norovirus episodes, the median cost was highest for norovirus episodes that required hospitalization compared with outpatient and ED episodes. ja.ma/43cIAqf
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Short-term multicancer screening trials may lead to meaningful reductions in late-stage #cancer incidence but only modest declines in mortality, with most impact driven by a few common cancers. ja.ma/46ZQzbg
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#Narcolepsy was not associated with increased all-cause or cause-specific mortality compared to matched controls/siblings in this study with 22-year follow-up. ja.ma/4nNvQic
Graph shows survival probability over time (years) for two cohorts: Cases (dark blue) and Controls (orange). Both start near 1.0, gradually decreasing, with Cases declining more sharply after 20 years. 'No. at risk' numbers are given.
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Pregnancy preferences are strongly associated with incident pregnancy, but the extent to which individuals achieve their reproductive goals varies by age, parity, cohabitation, education, employment, and racial and ethnic identity. ja.ma/3KJKU1G
Histogram showing 'Participants, %' on the y-axis from 0 to 8 and 'DAP score' on the x-axis from 0 to 4. The bar heights generally increase with the DAP score, with a significant spike at DAP score 4.
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Higher severity of exposure to dust and fumes at the World Trade Center sites was associated with increased lung #cancer incidence among responders more than a decade after the attacks. ja.ma/3VY4ycD
Graph showing cumulative hazard over time for mild, moderate, and severe exposure levels. The x-axis represents time since July 1, 2012, and the y-axis shows cumulative hazard. Severe exposure has the highest hazard.
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RCT: A self-guided smartphone app was linked to fewer depressive symptoms in people with intellectual disabilities. ja.ma/3VZYzUL
Infographic on a self-help app for depression in people with intellectual disabilities. Study included 45 males and 54 females with mean age 34.8. Results showed the app reduced depressive symptoms.
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#Medicaid primary care practice–led ACOs were associated with increased perinatal office visits, and health system-managed ACOs were associated with increased receipt of timely postpartum visits and decreased prenatal ER visits. ja.ma/4oa7gYr
Four line graphs comparing medical outcomes from 2016-2020. The graphs show: A) mean number of office visits, B) mean number of ED visits, C) proportion of deliveries that were cesarean, and D) proportion of deliveries with timely postpartum visits.
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Among individuals with #MentalIllness symptoms seeking holy water treatment in Ethiopia, only 1 in 6 sought professional care, and this treatment gap was associated with sociocultural, economic, and systemic challenges. ja.ma/3KNthxX
Bar graph showing mental health care prevalence. Those who sought treatment: ~18%. Those who did not: ~82%. Y-axis: Prevalence, %. X-axis: "Mental health care treatment sought" and "Mental health care treatment not sought"
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Physicians with higher professionalism and communication ratings in residency received better patient experience survey responses in early unsupervised practice. ja.ma/46RMG9P
JAMA Network Open article: "Trainee-Physician Milestones Ratings and Patient Experience Surveys in Early Unsupervised Practice" by Jenny X. Chen, Deirdre Mylod, Yuezhou Jing, et al. Published online October 8, 2025.
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Among US adults, immigrants with serious psychological distress who engaged in #PhysicalActivity had a lower risk of all-cause mortality compared to both inactive immigrants with distress and nonimmigrants. ja.ma/48fxDaW
Survival probability graph showing comparative trends for immigrants and non-immigrants, differentiated by SPA/IPA and presence/absence of SPD over 20 years.The No. at risk for each category is listed at different time intervals.
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First-line gene therapy for children with spinal muscular atrophy was associated with fewer unsatisfactory clinical responses and less respiratory and nutritional support over time, with similar motor outcomes compared to those treated with nusinersen. ja.ma/4h5Brhk
The image contains multiple scatter plots comparing treatment groups over time. Plot A displays 'CHOP INTEND score evolution by DMT treatment group', contrasting three therapies. Plot B shows 'CHOP INTEND score evolution in 12 matched pairs'.
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Older adults receiving federal housing assistance are less likely to be diagnosed with late-stage #cancers including breast, colorectal, and lung cancer, compared to individuals who received no assistance. ja.ma/3WqgpjU
Four bar graphs compare estimated probabilities for different cancers (breast, colorectal, NSCLC, prostate) across disease stages (in situ, local, regional, distant), differentiating between HUD-assisted and non-HUD-assisted cases.
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Among vulnerable populations in Lebanon facing multiple crises, food insecurity, lower wealth, and less education were associated with worse pain, self-rated health, and #depression, with additional differences by nationality and sex. ja.ma/4of6Tfv
Two line graphs show trends from June 2022 to July 2024. Graph A, "Food insecurity," shows percentage of participants fluctuating between 65% and 90%. Graph B, "Low wealth," shows participant percentages between 30% and 60%, peaking in April 2024.
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RCT: Among adults aged 65 years or older in Hong Kong, use of a hybrid chatbot was associated with higher pneumococcal vaccination uptake and improved stage of change scores compared to use of a standard chatbot intervention. ja.ma/439EwqG
JAMA Network Open infographic about a hybrid chatbot to promote pneumococcal vaccination among older adults. The population was 161 men, 213 women. The rate of vaccination uptake for the stage change intervention was 29.4% vs 18.7% for standard intervention.
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RCT: Open-label placebo treatment for #migraine was not associated with fewer #headache or migraine days, but was associated with improved pain-related disability, quality of life, and global patient-reported improvement compared to usual care. ja.ma/4709BhU
Infographic titled, "RCT: Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine" shows study population was 17 men and 103 women. Findings show no significant decrease in MHD in the OLP group, compared to the TAU group.
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Use of sugammadex during minimally invasive inguinal hernia repair was associated with a lower rate of postoperative urinary retention and shorter hospital stay compared to traditional reversal agents. ja.ma/4nN4sB6
JAMA Network Open article: "Sugammadex for Postoperative Urinary Retention in Minimally Invasive Inguinal Hernia Repair: A Nonrandomized Clinical Trial" by William R. Lorenz, Alexis M. Holland, Brittany S. Mead, et al. Published Oct 7, 2025.
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Black adolescents, on average, reported experiencing 6 online race-related experiences per day and negative experiences were associated with poor #mentalhealth. ja.ma/42sLS8E
https://ja.ma/48SF0VZ
Adolescents’ Race-Related Online Experiences and Mental Health
ja.ma
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A two-stage screening of 754 preschoolers in Austria found 4.4% needing therapy for motor deficits and 2.1% with critical motor skills based on validated assessments, yet none of these children’s parents reported concerns. ja.ma/4o7E1FS
JAMA Network Open article: "Unrecognized Motor Difficulties and Developmental Coordination Disorder in Preschool Children" by Barbara Scheiber, Claudia Spiegl, Jasmin Plattner, et al. Published October 7, 2025.