Jerome Ezan
@jezan.bsky.social
160 followers 240 following 11 posts
INSERM researcher at Neurocentre Magendie / @neurobordeaux.bsky.social / @univbordeaux.bsky.social Mount Sinai, NYC @sinaiirm.bsky.social alumnus Cell and developmental biology are my favorite! "As above, so below"
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jezan.bsky.social
A big thank you to all authors, especially Marius Halliez and Laure Strochlic for their incredible contributions to this project!
jezan.bsky.social
Our collaborators showed that passive transfer of anti-MuSK CRD antibodies in mice induced hallmark features of #myastheniagravis (MG), providing the 1st evidence of the MuSK CRD domain’s involvement in MG pathogenesis and advancing our understanding of its underlying pathophysiological mechanisms.
jezan.bsky.social
As part of our team in @neuromagendie.bsky.social – INSERM U1215 and the Bioprot Platform in @neurobordeaux.bsky.social , we designed and carried out the purification of the MuSK CRD peptide, a key step that enabled the successful production of rabbit anti-MuSK CRD antibodies.
jezan.bsky.social
I'm thrilled to share our contribution in a collaborative work with Laure Strochlic ‘s team, that is now published in the Journal of Clinical Investigation!
www.jci.org/articles/vie...
JCI - MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis
www.jci.org
jezan.bsky.social
Beautiful periodicity!
jezan.bsky.social
Thrilled to host the #Syncell Inc #Microscoop event on March 21st in #Bordeaux!

Anybody interested in the prospects of #spatialproteomics is more than welcome!

📍 **Location:** Amphi Broca Nouvelle Aquitaine, Bordeaux
📅 **When :** March 21st, 2:00pm-3:30pm
Reposted by Jerome Ezan
jezan.bsky.social
already a must read. The latest about the #axoninitialsegment !
Reposted by Jerome Ezan
sophiemartinlab.bsky.social
The Martin lab has an open postdoc position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community!

If interested, do not hesitate to contact us: mocel.unige.ch/research-gro...

Please RT!
Reposted by Jerome Ezan
jbwallingford.bsky.social
Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues.

www.cell.com/cell/fulltex...
Reposted by Jerome Ezan
christlet.bsky.social
A neuronal Rube Goldberg machine 🤯
Wnt from surrounding cells is internalized via clathrin-coated pits at dendritic branch points before triggering microtubule nucleation at the surface of endosomes. Great work from Melissa Rolls' lab in @plosbiology.org: journals.plos.org/plosbiology/...
Cartoon of the mechanism from the last figure of Thyagarajan et al.
jezan.bsky.social
at least, the "massues" are not on fire!
jezan.bsky.social
I wish I had this a few years back!