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Reposted by Jonathan G. Stine, MD MSc, FACP

The Baveno Cooperation: an EASL Consortium @bavenocoop.bsky.social · Jul 16

🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation.

A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.

Rest in peace, Jaime

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Jun 27

Celebrated 8 incredible years of Stine Lab with a team lunch today! Grateful for the hard work, discoveries, and camaraderie that made our journey so impactful. Here’s to the science, the memories, and the friendships that last far beyond the lab. #MASLD #Research

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Jun 1

The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD.

Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.

Its time to standardize definitions and intervene early:

link.springer.com/article/10.1...

Reposted by Jonathan G. Stine, MD MSc, FACP

Tom Marjot @tom-marjot.bsky.social · May 25

📢Great to write this review for Hep Comms with Matt Armstrong & @jonathanstinemd.bsky.social

💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise

🔗 shorturl.at/aFO1Q

#LiverSky

Graphic showing assessment methods for various domains of muscle quality and function in patients with MASLD including insulin resistance, myosteatosis, sarcopenia, and frailty.

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · May 23

It was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle!

If you're looking for holiday weekend reading, look no further:

journals.lww.com/hepcomm/page...

@ebtapper.bsky.social

Skeletal muscle and MASLD: Mechanistic and clinical insights : Hepatology Communications

, which all converge on the liver to drive disease progression and adverse patient outcomes. This review explores the mechanistic links between skeletal muscle and MASLD, including the role of abnorma...

journals.lww.com

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Reposted by Jonathan G. Stine, MD MSc, FACP

WHO @who.int · May 16

Choose to walk 🚶‍♂️ or cycle 🚲 whenever possible.

It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.

Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive

People walking, cycling, and using wheelchairs on a safa road. Text reads: “Hit that step count, or hop on your bicycle! Reclaim your health, and the health of the planet.”

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · May 12

New review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke

Read here: sciencedirect.com/science/arti...

Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease

Autophagy, a highly conserved cellular degradation pathway promotes cell survival via lysosomal degradation of aberrant cellular proteins and recyclin…

sciencedirect.com

Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · May 12

Heading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth

Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Apr 22

Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Apr 16

#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃‍♀️🧬

New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence

pubmed.ncbi.nlm.nih.gov/40206477/

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Reposted by Jonathan G. Stine, MD MSc, FACP

Eric Topol @erictopol.bsky.social · Apr 14

Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Apr 14

Ok, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂

Reposted by Jonathan G. Stine, MD MSc, FACP

Lindsey Kennedy @livernotfighter.bsky.social · Apr 7

🚨Steatotic liver disease driven by senescent hepatocytes

🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage

www.nature.com/articles/s41...

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction - Nature Communications

MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively e...

www.nature.com

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Reposted by Jonathan G. Stine, MD MSc, FACP

Nicholas A. Christakis @nachristakis.bsky.social · Mar 31

I join >1900 members of US National Academies of Science, Engineering, and Medicine signing this letter, as individuals, decrying the present thoughtless assault on science, which is against our national interests. docs.google.com/document/d/1... Our health, wealth, and security depend on science.

Public Statement on Supporting Science for the Benefit of All Citizens

TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...

docs.google.com

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Reposted by Jonathan G. Stine, MD MSc, FACP

Eric Topol @erictopol.bsky.social · Apr 1

How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...

HHS starts layoffs of thousands of workers across its agencies

Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.

www.statnews.com

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Mar 28

And the CHRONO-NAFLD study can be read here:

onlinelibrary.wiley.com/doi/full/10....

Effects of a 12‐Week Mediterranean‐Type Time‐Restricted Feeding Protocol in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial—The ‘CHRONO‐NAFLD Project’

This study corroborates the efficacy of the Mediterranean diet (MD) in ameliorating cardiometabolic risk factors such as body weight and blood pressure in patients with MASLD and overweight/obesity. ...

onlinelibrary.wiley.com

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Mar 28

🔥🆙 to publish alongside my pre-doc #HannahMohrMS in
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study

Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...

Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)!

Click on the article title to read more.

onlinelibrary.wiley.com

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Reposted by Jonathan G. Stine, MD MSc, FACP

Thanh Neville, MD, MSHS @thanhneville.medsky.social · Mar 18

THIS: The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
www.amfar.org/news/how-nih...

The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth

Continued investment in the NIH is essential to fighting current and emerging health threats and to ensuring the U.S. remains a global leader in medical innovation.

www.amfar.org

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Reposted by Jonathan G. Stine, MD MSc, FACP

Elliot Tapper @ebtapper.bsky.social · Mar 25

The liver loves aerobic exercise

journals.lww.com/hepcomm/full... #liversky

Aerobic exercise interventions lead to MASH resolution in... : Hepatology Communications

An abstract is unavailable.

journals.lww.com

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Mar 26

Thanks for sharing our work!

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Reposted by Jonathan G. Stine, MD MSc, FACP

Hannes Hagström @liverepi.bsky.social · Mar 24

New paper from us in @jhepatology.bsky.social: www.journal-of-hepatology.eu/article/S016...
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!

Cause-specific mortality in 13,099 patients with metabolic dysfunction-associated steatotic liver disease in Sweden

Data on cause-specific mortality in metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. We aimed to determine the rate and risk of death from different causes in patients wit...

www.journal-of-hepatology.eu

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Mar 20

Proud to have been your resident! #HoyaSaxa!

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Reposted by Jonathan G. Stine, MD MSc, FACP

aga-gihn.bsky.social @aga-gihn.bsky.social · Mar 18

Our March member spotlight is Dr. Pooja Singhal! She discusses the critical role women #GI docs play in assisting the unique needs of female patients, her involvement in the @amergastroassn.bsky.social Women in GI Workshop & more: buff.ly/dFGqZ2d

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Reposted by Jonathan G. Stine, MD MSc, FACP

Eric Topol @erictopol.bsky.social · Mar 6

In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.

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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · Mar 18

Join us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways!

Register here: ce.med.psu.edu/mash/

It’s free!

Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day - Penn State College of Medicine Continuing Education

Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day is a continuing education program of Penn State College of Medicine taking place in Hershey, Pa.

ce.med.psu.edu

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