Lightnews — Scholar-powered news

Reposted by Mari Sepp

Denis Duboule @denisduboule.bsky.social · 7d

Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social

15 22

Reposted by Mari Sepp

Simons Foundation @simonsfoundation.org · 23d

Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/

Simons Foundation Announces Recipients of 2025 Fellows-to-Faculty Awards

The Simons Foundation is pleased to announce the 2025 class of Fellows-to-Faculty Fellows.

www.simonsfoundation.org

2 14 34

Reposted by Mari Sepp

Kaessmann Lab @kaessmannlab.bsky.social · 29d

👇 !!!

Louis-Jeantet Foundation @louisjeantetfdn.bsky.social · Sep 9

Register to attend the #LouisJeantetSymposium on vertebrate genome #evolution. Organised by Svante Pääbo and
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/

📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social

3 5

Reposted by Mari Sepp

Lili Milani @lilimilani.bsky.social · Sep 4

Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍

European Research Council (ERC) @erc.europa.eu · Sep 4

Are adult attention deficit hyperactivity disorder (ADHD) features truly the same as childhood ADHD?

Kelli Letho, a new ERC Starting Grantee at the University of Tartu will dissect the causal mechanisms of adult ADHD features

More 👉 buff.ly/nci5eve

#ERCStG #FontierResearch @klehto.bsky.social

4 16

Reposted by Mari Sepp

Baptiste Libé-Philippot @blibep.bsky.social · Jul 30

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher in human neurobiology (M/F)

emploi.cnrs.fr

1 23 20

Mari Sepp @marisepp.bsky.social · Jul 29

Congrats, Valentina! Great to see this study out!

1 1

Reposted by Mari Sepp

Valentina Cerrato @valentinacerr.bsky.social · Jul 29

🔬 New preprint out!

Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.

📄 www.biorxiv.org/content/10.1...

#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social

Just a moment...

Verifying you are human. This may take a few seconds.

https://biorxiv.org/content/10.110…

3 5 13

Reposted by Mari Sepp

Anne West @ennatsew.bsky.social · Jul 27

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

1 51 58

Reposted by Mari Sepp

katja heuer @k4tj4.bsky.social · Jul 27

1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

15 230 500

Reposted by Mari Sepp

Sergio Menchero @sermenchero.bsky.social · Jul 24

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs

Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

www.cell.com

11 33 72

Reposted by Mari Sepp

Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

www.nature.com

10 58 120

Reposted by Mari Sepp

Kevin Mitchell @wiringthebrain.bsky.social · Jul 14

Human de novo mutation rates from a four-generation pedigree reference www.nature.com/articles/s41... - amazingly comprehensive study from Evan Eichler and colleagues

Human de novo mutation rates from a four-generation pedigree reference - Nature

Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set t...

www.nature.com

1 3 9

Reposted by Mari Sepp

Christian Mayer @chr-mayer.bsky.social · Jul 8

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

www.nature.com

3 12 32

Mari Sepp @marisepp.bsky.social · Jul 1

🤩 Happy to see my PhD mentor Tõnis Timmusk elected as a Member of the European Molecular Biology Organization ‪@embo.org‬. So well-deserved!
An inspiring scientist, supportive mentor, and generous friend! ‪
@taltech.bsky.social‬

EMBO @embo.org · Jul 1

Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪

Learn more here:
www.embo.org/press-releas... #EMBOMembers2025

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO

Sixty-nine new members join the community of leading life scientists in Europe and beyond

www.embo.org

6

Reposted by Mari Sepp

Lena Kutscher @lenakutscher.bsky.social · Jun 29

Did the miss the Cerebellum Development and Disease conference last year? Never fear, as we wrote up a conference report! link.springer.com/article/10.1...

Conference Report: Cerebellar Development and Disease at Single-Cell Resolution - The Cerebellum

The Cerebellum -

link.springer.com

2 2 7

Reposted by Mari Sepp

Justus Kebschull @justuskebschull.bsky.social · Jun 26

Excited to share the first 2(!) preprints from the Kebschull Lab. The amazing @hyopilkim.bsky.social developed MAPseq2 & POINTseq and used them to map the dopaminergic cells of VTA and SNc. tl;dr MAPseq2=10x cheaper, 4x better; POINTseq=easy cell type specific barcoding; DA neurons=very cool.

2 12 35

Reposted by Mari Sepp

Kaessmann Lab @kaessmannlab.bsky.social · Jun 20

We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...

4 36 90

Reposted by Mari Sepp

Sofie Valk @sofievalk.bsky.social · Jun 6

What about the social cerebellum during development we wondered? Here you find some cool insights on this awesome part of the brain! BIG thanks for the great work Katerina Manoli, and support from Charlotte Grosse Wiesmann and Frank van Overwalle 🧠🦋 rdcu.be/epKmZ

Functional recruitment and connectivity of the cerebellum is associated with the emergence of Theory of Mind in early childhood

Nature Communications - The cerebellum is heavily implicated in adult social cognition, but its role in Theory of Mind development remains unclear. Here, the authors show that children’s...

rdcu.be

2 10 27

Reposted by Mari Sepp

Joshua Weitz @joshuasweitz.bsky.social · Jun 2

Get the word out far and wide. New opportunity from the Simons Foundation in the Eco-Evo space.

2026 Simons Graduate Fellowship in Ecology and Evolution Awards, due July 31, 2025, only for incoming PhD students who plan to start their PhDs in Fall 2026.

www.simonsfoundation.org/grant/simons...

Simons Graduate Fellowships in Ecology and Evolution

The purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...

www.simonsfoundation.org

2 77 52

Mari Sepp @marisepp.bsky.social · May 17

Congrats! Looking forward to diving in

1 2

Reposted by Mari Sepp

Cedric Boeckx @cedricboeckx.bsky.social · May 16

New preprint alert 📣
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...

www.biorxiv.org

5 26 59

Reposted by Mari Sepp

Lars Velten @larsplus.bsky.social · May 8

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵

Design principles of cell-state-specific enhancers in hematopoiesis

Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

www.cell.com

4 57 140

Mari Sepp @marisepp.bsky.social · May 7

Big congrats to our longtime collaborators in the Stefan Pfister and @lenakutscher.bsky.social labs — large-scale chromosomal changes as early tumour-initiating events in Group 3/4 medulloblastoma!

Barbara Marte @barbmarte.bsky.social · May 7

new out in Nature www.nature.com/articles/s41...

Oncogene aberrations drive medulloblastoma progression, not initiation - Nature

A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for...

www.nature.com

1 2 5

Mari Sepp @marisepp.bsky.social · May 7

Had the same question :) In our datasets of cerebellum development, Fam210b has the highest expression in granule cell progenitors, in human and mouse.

3