Lena Kutscher
@lenakutscher.bsky.social
420 followers
300 following
39 posts
Scientist at dkfz, Twin mom + 1. Developmental Origins of Pediatric Cancer junior group leader. Interested in cerebellum development, tumor initiation, and cell death 🧪
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Reposted by Lena Kutscher
Reposted by Lena Kutscher
Alex Eve
@amjeve.bsky.social
· Aug 20
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Lena Kutscher
@lenakutscher.bsky.social
· Jun 29
Lena Kutscher
@lenakutscher.bsky.social
· Jun 29
Reposted by Lena Kutscher
Lena Kutscher
@lenakutscher.bsky.social
· Jun 20
Reposted by Lena Kutscher
Cancer Cell
@cp-cancercell.bsky.social
· Jun 16
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instability, and accelerated cell cycle. Pharmacological restoration of p53 signaling in ELP1-deficient tumor cells suppresses tumor growth and represents a potential therapeutic opportunity.
dlvr.it
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Mari Sepp
@marisepp.bsky.social
· May 7
Barbara Marte
@barbmarte.bsky.social
· May 7
Oncogene aberrations drive medulloblastoma progression, not initiation - Nature
A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for...
www.nature.com
Reposted by Lena Kutscher
Barbara Marte
@barbmarte.bsky.social
· May 7
Oncogene aberrations drive medulloblastoma progression, not initiation - Nature
A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for...
www.nature.com
Reposted by Lena Kutscher
Reposted by Lena Kutscher
Carl T. Bergstrom
@carlbergstrom.com
· Apr 14
Jacob T. Levy
@jacobtlevy.bsky.social
· Apr 14
Reposted by Lena Kutscher