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Nima Sharifi MD @nimasharifimd.bsky.social · 3d

Latest clinical data on HSD3B1 presented at ASTRO www.urotoday.com/conference-h...

ASTRO 2025: Influence of HSD3B1 Genotype on Prostate Cancer Outcomes Following Definitive Radiation Therapy with ADT: A Retrospective Analysis of the Million Veterans Program

prostate cancer, HSD3B1 Genotype, Influence of HSD3B1 Genotype on Prostate Cancer Outcomes Following Definitive Radiation Therapy with ADT.

www.urotoday.com

Nima Sharifi MD @nimasharifimd.bsky.social · 7d

"Rockets, computers and lifesaving medicines all come from decades of effort by scientists hunkered over pages of calculation or the laboratory bench. They required the same tireless, single-minded effort every elite athlete understands." 🧪 @adamfrank4.bsky.social www.nytimes.com/2025/10/03/o...

Opinion | How the Manosphere Hijacks Young Men’s Interest in Science

www.nytimes.com

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Nima Sharifi MD @nimasharifimd.bsky.social · 14d

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Nima Sharifi MD @nimasharifimd.bsky.social · 15d

We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...

Faculty – Assistant, Associate and Full Professor - Miami, Florida (US) job with Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center | 675109

The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.

jobs.sciencecareers.org

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Reposted by Nima Sharifi MD

Science Friday @scifri.bsky.social · 20d

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

A Trailblazing Geneticist Reflects On Her Life And Work

Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

buff.ly

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Nima Sharifi MD @nimasharifimd.bsky.social · 20d

These pelicans out this morning are just magnificent and mesmerizing to watch

Nima Sharifi MD @nimasharifimd.bsky.social · Sep 3

Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses www.nytimes.com/2025/09/02/s...

Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses

www.nytimes.com

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Nima Sharifi MD @nimasharifimd.bsky.social · Aug 27

Congratulations @marinaparry.bsky.social! Wonderful work!

Marina Parry @marinaparry.bsky.social · Aug 27

REALLY thrilled to share findings from my postdoc work in the Attard lab, which form part of this www.sciencedirect.com/science/arti....

Thanks to Emily and Gert for seeing it over the line, all the funders, the Veracyte, MRC CTU & STAMPEDE teams, and patients who contributed samples. Pls share!

Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers

Advanced prostate cancers respond to hormone therapy but outcomes vary and no predictive tests exist for informed treatment selection. To identify nov…

www.sciencedirect.com

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 30

Enjoyed working with Masoud Bitaraf and Elena Castro on this review on prostate cancer germline variants with therapeutic implications for Trends in Molecular Medicine! 🧪 #UroSky #MedSky @cp-trendsmolecmed.bsky.social authors.elsevier.com/a/1lWYz5Eb1B...

authors.elsevier.com

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 29

Congrats to you and your team, Ralph! @rjdlab.bsky.social

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Reposted by Nima Sharifi MD

Josh Lang @joshlangmd.bsky.social · Jul 25

Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!

cancer.wisc.edu/community-ou...

Cancer Clear and Simple Podcast

Welcome to ‘Cancer Clear and Simple,’ the podcast dedicated to simplifying cancer. Join us as we discuss the world of cancer, breaking down complex concepts for our listening audience. One of our goal...

cancer.wisc.edu

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 25

I consider myself fortunate for every day I can continue to do science

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 15

An Editor's Pick paper at J Biol Chem @asbmb.bsky.social! Don't forget to read the profile about the first author Xiuxiu Li at the end of our paper on HSD3B1 and breast cancer! Dr. Li recently moved from University of Miami to the University of Alabama! 🧪 www.sciencedirect.com/science/arti...

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Reposted by Nima Sharifi MD

Jon Wolf Mueller @jonwolfmueller.bsky.social · Jul 11

...a long way to go...

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 11

😣😩😭

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 8

Sage advice as always from @rjdlab.bsky.social 🧪

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 8

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I

An unexpected career in cancer metabolism

Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

rdcu.be

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 7

So impressed with the survival effects of excercise in this study in stage 2/3 colorectal cancer. Survival effects apparently independent of weight loss. How does it work? @nejm.org 🧪 www.nejm.org/doi/full/10....

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM

Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

www.nejm.org

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Nima Sharifi MD @nimasharifimd.bsky.social · Jul 6

I love coming across these majestic creatures! #pelicans

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Nima Sharifi MD @nimasharifimd.bsky.social · Jun 27

Congrats Zhenfei Li and his team on his story @pnas.org on fine structural design of 3βHSD1 inhibitors for prostate cancer therapy! His work builds on many years of work on HSD3B1 genetics and metabolism in prostate cancer! @pcf-science.bsky.social 🧪https://www.pnas.org/doi/10.1073/pnas.2422267122

Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy | PNAS

Prostate cancer is a global health challenge, particularly for patients resistant to the second-generation anti-androgen receptor pathway inhibitor...

www.pnas.org

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Nima Sharifi MD @nimasharifimd.bsky.social · Jun 25

Do you have a primary interest in fundamental mechanisms of human biology, biochemistry, metabolism, genetics, or medicinal and analytical chemistry and looking for a postdoctoral fellowship? 🧪 www.nature.com/naturecareer...

Postdoctoral Associate – Nima Sharifi Laboratory - Miami, Florida (US) job with University of Miami Desai Sethi Urology Institute | 12840300

The Nima Sharifi Laboratory is seeking to recruit outstanding postdoctoral associates with a primary interest in the fundamental mechanisms of huma...

www.nature.com

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Nima Sharifi MD @nimasharifimd.bsky.social · Jun 21

Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext

HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer

Endocrine resistance is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancer, often leading to disease recurrence and metastasis. 3β-Hydroxysteroid dehydrogenase 1 (3βH...

www.jbc.org

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Nima Sharifi MD @nimasharifimd.bsky.social · Jun 20

So proud of @charles-dai.bsky.social who just landed a Damon Runyon Physician-Scientist Award! Charlie was previously an HHMI med fellow in our group. He truly has all the "right stuff" as he is becoming a leading investigator in breast and prostate cancers! 🧪 www.damonrunyon.org/news/entries...

Damon Runyon Cancer Research Foundation invests nearly $1.4 million to support physician-scientists

www.damonrunyon.org

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Nima Sharifi MD @nimasharifimd.bsky.social · Jun 19

Congratulations to Francesca Demichelis at U Trento on her and her team’s study just out in Cancer Discovery @theaacr.bsky.social aacrjournals.org/cancerdiscov...

Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis

Abstract. The biological mechanisms underlying the cooperation between germline genetic variants and somatic mutations during carcinogenesis are rarely elucidated. Here, characterizing isogenic prosta...

aacrjournals.org

Nima Sharifi MD @nimasharifimd.bsky.social · Jun 3

Really amazing! 🧪 www.nejm.org/doi/full/10....

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM

Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

www.nejm.org

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