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Ronald Beavis ❌ @ronbeavis.bsky.social · 14h

The CoCoRaHS daily precipitation map for this morning shows the impact of the current nor'easter on the US Atlantic coast.

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Ronald Beavis ❌ @ronbeavis.bsky.social · 16h

FOXF1 (forkhead box family F, member 1) has a single structured domain (winged helix DNA-binding/forkhead box) with 2 or 3 well-conserved pS-IDRs. The ratio of residues associated with (α+β):(IDR) is 28:72. #proteomics

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

Is it true that low complexity sequences are under-represented in MHC class I and/or II peptides? If it is true, what is the mechanism for leaving out these sequences? #proteomics

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Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

The current wind prediction for Monday's nor'easter on the US Atlantic coast, driven by 2 lows & a ridge.

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

As is usually the case, the kinase(s) & phosphatase(s) involved are unknown.

Ronald Beavis ❌ @ronbeavis.bsky.social · 1d

FOXA1:p (forkhead box A1) has a single forkhead DNA binding domain just nward of the middle, with a two acceptor phosphoIDR just cward of the middle. Both of the pS acceptors are occupied most of the time. #proteomics

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Reposted by Ronald Beavis ❌

Phil W @pwilmarth.bsky.social · 2d

You have to pay extra to enable the pet scan mode on Thermo Oribis...

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Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

IMHO paleoproteomics is for entertainment purposes, only.

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Reposted by Ronald Beavis ❌

Jennifer Robson 🇨🇦 @jrobson.bsky.social · 2d

Announcement from PM Carney moments ago and this is good news. I've been working on this issue with @saulschwartz.bsky.social and @agenestgregoire.bsky.social for years. We've documented how many Canadians don't file and miss out on or loose benefits, .. 1/3

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Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

If there is a second DNA-binding domain nward of the homeodomain in the sequence, the active pS acceptors flank this nward domain. Ta-da!

Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

I must admit that taking a look at the phosphorylation patterns associated with transcription factors with homeodomains (homeobox-containing genes) has been kind of a let down. In sequences that rely on a single homeodomain for DNA-binding specificity, the active pS acceptors flank the homeodomain.

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Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

I think that from a dose-response point of view, to get the sort of stray hair that you get from a wool sweater you would need to have the pet on the lab bench & be giving it a brush during sample prep.

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Reposted by Ronald Beavis ❌

Ardem Patapoutian @ardemp.bskyverified.social · 2d

The Nobel Peace Committee sent a clear message to someone else in awarding the Prize to Ms. Machado:
”But democracy is also in retreat internationally. Democracy – understood as the right to freely express one’s opinion, …is the foundation of peace both within countries and between countries.” 👏

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Ronald Beavis ❌ @ronbeavis.bsky.social · 2d

PKNOX1:p (pre-B-cell leukemia transcription factor/knotted 1 homeobox 1) has the same shiny domain set and arrangement as MEIS proteins, except that its S+phosphoryl acceptors are on the N-flank of the nward DNA interaction domain (MEIS has them on the C-flank). #proteomics

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Reposted by Ronald Beavis ❌

Le Monde @lemonde.fr · 3d

A Chicago, une juge bloque le déploiement de centaines de gardes nationaux qui devaient épauler la police de l’immigration

Une juge fédérale, saisie par les autorités locales, a écarté tout « danger de rébellion » dans l’Etat d’Illinois, s’opposant aux arguments de l’administration Trump qui a dépêché près de 500 soldats sur place.

www.lemonde.fr

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Reposted by Ronald Beavis ❌

Nora Loreto @nolore.bsky.social · 3d

Please everyone buy my latest book which is all about this problem and how we can fix it. It has, of course, been ignored by the mainstream press.

www.dundurn.com/books_/t2211...

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Ronald Beavis ❌ @ronbeavis.bsky.social · 3d

And how is that not a good thing?
www.theverge.com/news/674366/...

Nick Clegg says asking artists for use permission would ‘kill’ the AI industry

Paul McCartne, Elton John and others signed an open letter.

www.theverge.com

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Ronald Beavis ❌ @ronbeavis.bsky.social · 3d

MEIS1:p & MEIS2:p (Myeloid Ecotropic Viral Integration Site homeobox 1 & 2) have 2 bright shiny DNA interaction domains. Both have their S+phosphoryl functional modulation in the pIDR between these domains, with the most prominent acceptors on the C-flank of the nward domain. #proteomics

Reposted by Ronald Beavis ❌

Reece Martin @rmtransit.bsky.social · 4d

Everyone in Toronto knows the streetcars are slow and mismanaged (I wish our politicians actually *did* something about this), and yet we spent a generation of transit investments on building what amounts to more of them (which will be poorly run) in places we should have built subways.

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Reposted by Ronald Beavis ❌

Forbes @forbes.com · 5d

Oracle zero-day vulnerabilities are being targeted by at least one major cybercrime group and the FBI says it's looking bad.

FBI Is Warning Companies To Patch Their Oracle Databases Immediately

Oracle zero-day vulnerabilities are being targeted by at least one major cybercrime group and the FBI says it's looking bad.

www.forbes.com

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Reposted by Ronald Beavis ❌

Alex Usher @alexusherhesa.bsky.social · 4d

1) Classic Canadian fallacy that the answer to a labour shortage is that we need more bodies, not more efficiency/better training etc

2) Everyone knows that we admit about 100,000 new people into skilled trades apprenticeships every year, right? Right?

The Globe and Mail @theglobeandmail.com · 4d

Carney’s building agenda could be hamstrung by labour shortages, Deloitte report says

Report says Canada needs around half a million more tradespeople to meet Mr. Carney’s ambitions for housing and infrastructure

www.theglobeandmail.com

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Reposted by Ronald Beavis ❌

Denise Wheeler @denisedwheeler.bsky.social · 5d

Reuters photographer Jonathan Ernst noticed that Bondi flipped open a file during the Senate hearing and he zoomed in.

Inside were her crib notes for attacking the senators.

The GOP now practicing Cliff's Notes Fascism

In other words, under oath Bondi was purely a performance.

Bondi senate hearing had a folder full of notes for attacking the senators

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Ronald Beavis ❌ @ronbeavis.bsky.social · 4d

Personally, I think a result isn't really worth pursuing unless the underlying protein has been observed in >1000 LC/MS/MS runs & the feature of interest has been observed a few hundred times by multiple groups. But, I am―as everyone knows―more than a bit of an odd ball.

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Ronald Beavis ❌ @ronbeavis.bsky.social · 4d

Michael is involved in a data based effort to do a better job (APPRIS) & I found his enthusiasm for using the preponderance of information from as many sources as possible to be very encouraging.

Ronald Beavis ❌ @ronbeavis.bsky.social · 4d

For those of you who haven't noticed, I have really enjoyed the posts by @michaeltress.bsky.social in response to my earlier rant involving the use of rules to select special splice variant mRNA (#CanonFolly).

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