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Selene FeRNAndez @selfdz.bsky.social · 5d

Y si se lo perdieron, aquí está el link de Spotify:

open.spotify.com/episode/19mM...

Selene FeRNAndez @selfdz.bsky.social · 12d

Si les interesa saber de la Antártida 🇦🇶🐧, y el trabajo que realizamos en el #RegRNALab @unswbabs.bsky.social @unswrna.bsky.social, los invito a escuchar Mutante 🧬 en Radio UAEM 📻

📅 Lunes 29 de Sept, 4 pm 🇲🇽, martes 30 de Sept, 8 am, AEST 🇦🇺

Gracias @elagusdekomodo.bsky.social!

radio.uaem.mx/en-vivo

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Selene FeRNAndez @selfdz.bsky.social · 13d

Sad to miss you! Hope you have an excellent time @molbiosystems.bsky.social

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Reposted by Selene FeRNAndez

Alex Stark @alex-stark.bsky.social · Sep 11

Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!

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Reposted by Selene FeRNAndez

Antonio Camargo @apcamargo.bsky.social · Sep 6

A BLAST update adding support for compressed files and csv output with headers is a Good Friday night surprise!

blast.ncbi.nlm.nih.gov/doc/blast-ne...

2025 BLAST NEWS — BlastNews 0.1.1 documentation

blast.ncbi.nlm.nih.gov

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Reposted by Selene FeRNAndez

Natalia Sampaio @drnatsampaio.bsky.social · Sep 3

Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky

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Reposted by Selene FeRNAndez

Martin Smith @martinalexsmith.bsky.social · Sep 3

Prof Cecile King finishing her #ARNASydney2025 talk on biomolecular condensates by promoting the upcoming (free) symposium on the topic in November

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Selene FeRNAndez @selfdz.bsky.social · Sep 5

Things are happening 🌱 #RegRNALab

@unswbabs.bsky.social

Picture of agar dish with two rows of plant seedlings held by a gloved hand

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

MD tells us a lot more on drugging microRNAs, cancer RNAs and many more. So many options. Also discusses Chem-CLIP to interrogate molecular recognition events in live cells. And advancement on this is ChemCLIP-Map-Seq, which allows direct identification using NGS.

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

Small molecules can also be used to affect #RNA lifetime, by triggering degradation. Their main target is diseases triggered by intronic RNA repeats that impair splicing. They found multiple ways to do this. For references see pic 👇🏼

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

Small molecules can also be used to affect #RNA lifetime, by triggering degradation. Their main target is diseases triggered by intronic RNA repeats that impair splicing. They found multiple ways to do this. For references see pic 👇🏼

Selene FeRNAndez @selfdz.bsky.social · Sep 3

Once they could identify these interactions, they developed Inforna, which mines secondary structures within target RNAs, and compares them to their database of known RNA motif–small molecule binding partners. Latest Inforna update 👇🏼

pubs.acs.org/doi/10.1021/...

#ARNASydney2025 #RNASky

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

The development of small molecules that target RNA is challenging yet, if successful, could advance the development of chemical probes to study RNA function or precision therapeutics to treat RNA-medi...

pubs.acs.org

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

To identify targets they developed an #RNA encoded motif library and tested it against a DNA encoded library, allowing them to test > 300 million interactions through FACS sorting.

Full paper:

www.pnas.org/doi/full/10....

#ARNASydney2025 #RNASky

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor | PNAS

Nature evolves molecular interaction networks through persistent perturbation and selection, in stark contrast to drug discovery, which evaluates c...

www.pnas.org

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

His lab is aiming to take human RNAs that cause disease, specifically:

- How to target human RNAs with small molecules/chemical proves in scalable and defined ways?

How to find these molecules, how to test for binding, how to assess how/if they are working?

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

We are now listening to our Keynote speaker, Matt Disney, from The Scripps Research Institute 🇺🇸, who due to unforseen circumstances could not join us in-person. Matt's presentation was generously sponsored by the UNSW RNA Institute (@unswrna.bsky.social)

#ARNASydney2025 #RNASky

🧵👇🏼

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

Closing the session, we have Alexander Gillis from @scottbscience.bsky.social lab, talking about their latest insights on transcriptional homeostasis. Interestingly, despite triggering a Pol II accumulation in human cells, there is no increase in transcription.

#ARNASydney2025 #RNASky

Selene FeRNAndez @selfdz.bsky.social · Sep 3

Now's the turn of Sebastian Leidel, from the University of Bern 🇩🇪, discussing how m6A mediates mRNA decay. Rapidly degraded mRNAs tend to have more m6A in their CDS, a signal that's generally missed in metagene plota of m6A. Codon choice & mRNA mods tune mRNA decay rates.

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 3

After some technical issues, we are now hearing from @traudebeilharz.bsky.social, on polyadenylation across the mRNA lifecycle. The shape of the Poly(A) tail is a marker of RNA fate and can be assessed using techniques such as PATTERNseq.

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

Starting the last day of #ARNASydney2025 with the RNA Processing and Modifications session. First, @edueyras.bsky.social, who is developing pipelines to identify #RNA modifications in using @nanoporetech.com

👀 this preprint on the conservation of RNA modifications:

www.biorxiv.org/content/10.1...

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

Yesterday, after our 2nd poster session and a stunning sunset seen from the Aerial UTS, we closed the day at our Evening Social at the Old Clare Hotel 🥂

Glad Sydney weather has been cooperating 🌤️

#ARNASydney2025

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

We wrap up the non-coding #RNA session with Sayanthooran Saravanabavan telling us about the computational discovery of TDP-43-Responsive Circular RNA:DNA Hybrids (circR-loops) in neuronal cells, particularly in the context of ALS.

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

Now is the turn of @stacedw.bsky.social telling us about a #lncRNA as a therapeutic for ER+ breast cancer. Cannot share more details, but I can say seeing the promise of #lncRNAs starting to bear fruit is very exciting!

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

Now Yuchen Feng @sydney.edu.au, tells us about the pan-cancer #lncRNA MILIP, which interacts with and enables the repression of p53 by c-Myc in cancer cells. MILIP also binds the elongation factor eEF1alpha1, promoting protein synthesis, by enhancing tRNA type II interaction

#ARNASydney2025 #RNASky

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Selene FeRNAndez @selfdz.bsky.social · Sep 2

We are now in the non-coding #RNA session at #ARNASydney2025. We heard a fascinating story on other functions of the TERRA #lncRNA, which binds ATRX and gene promoters. It also is more abundant in the aging brain. A great talk by Hsueh-Ping Chu from the National Taiwan University.

#RNASky

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Reposted by Selene FeRNAndez

Natalia Sampaio @drnatsampaio.bsky.social · Sep 2

Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠

Selene FeRNAndez @selfdz.bsky.social · Sep 2

We had a set of amazing talks in the #RNA in immunity session at #ARNASydney2025. Presentations by Stacey Horner, @drnatsampaio.bsky.social, Elizabeth Chan and Kitty McCaffrey. From viral infections to bacterial toxins, a really great session.

#RNASky

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