The transition from data scientist to patient–scientist has given me new perspectives into clinical research and strengthened my commitment to open science. Although limitations on data availability h...

The Nature editorial urges World Health Assembly delegates, meeting on 19 May 2025, to back a resolution led by Guatemala that would recognize chronic kidney disease (CKD)—which affects an estimated 8...

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The development and proper functioning of the kidney is dependent on the interaction of kidney cells with the surrounding extracellular matrix (ECM). These interactions are mediated by heterodimeric membrane-bound receptors called integrins, which bind to the ECM via their extracellular domain and via their cytoplasmic tail to intracellular adaptor proteins, to assemble large macromolecular adhesion complexes. These interactions enable integrins to control cellular functions such as intracellular signalling and organization of the actin cytoskeleton and are therefore crucial to organ function. The different nephron segments and the collecting duct system have unique morphologies, functions and ECM environments and are thus equipped with unique sets of integrins with distinct specificities for the ECM with which they interact. These cell-type-specific functions are facilitated by specific intracellular integrin binding proteins, which are critical in determining the integrin activation

World Kidney Day is a global campaign that aims to raise awareness of kidney disease and the importance of kidney health.

Research into women’s health has suffered from historical neglect and lack of funding.

NephMadness 2025 starts in less than 3 weeks!  Our 9-member Blue Ribbon Panel (BRP) will decide the outcome of each matchup as we March towards crowning a new champion. Here are the folks to blame …

Nature Reviews Earth & Environment - Extreme heat is increasing in magnitude and frequency, threatening human health. This Review assesses mortality risk associated with extreme heat, revealing...

Premature birth and low birth weight disrupt kidney development substantially, which leads to an increased risk of acute kidney injury, chronic kidney disease and hypertension. Broader awareness of th...

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Nature Reviews Nephrology, Published online: 06 January 2025; doi:10.1038/s41581-024-00927-wInnate immune memory represents a barrier to successful kidney transplantation. The discovery that uraemic toxins in people with kidney failure induce trained…