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Valentina Lo Sardo @valels.bsky.social · 5d

Wonderful meeting @aegeanstemcells.bsky.social! An incredible lineup of speakers and spectacular science. Thanks to our own Jeff @epigeneticsmsn.bsky.social for organizing this event. What could be better than having @uwmadscience.bsky.social CRB delegation in sunny Crete? @blanclab.bsky.social

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Valentina Lo Sardo @valels.bsky.social · Jun 5

Thanks to the UW-Madison Stem Cell and Regenerative Medicine Center for highlighting our recent work!!🫀🧫🔬

stemcells.wisc.edu/2025/06/04/u...

UW–Madison researchers find hidden clues in a decades-old mystery surrounding cardiovascular disease

Researchers at the University of Wisconsin–Madison have uncovered new evidence in a decades-old genetic mystery, discovering how multiple genetic variations in a long-mysterious region of the human ge...

stemcells.wisc.edu

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Valentina Lo Sardo @valels.bsky.social · May 22

If you are passionate about stem cells consider coming to Greece for a wonderful lineup of speakers, a lot of networking and amazing science!! Check the website for early registration and travel awards!

Aegean Conferences on Stem Cells @aegeanstemcells.bsky.social · Mar 12

🔬 6th International Aegean Conference on Stem Cells 📢
Join us Oct 1–6, 2025 in Crete, for talks on stem cell biology, regenerative medicine, genome editing & aging.

📅 Abstracts & Early Reg: Due June 1, 2025
🔗 Register now: www.aegeanconferences.org/src/App/conf...

#AegeanStemCells2025 #StemCells

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Valentina Lo Sardo @valels.bsky.social · Apr 22

Ready for the next three days of great science #VascularDiscovery25

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Valentina Lo Sardo @valels.bsky.social · Apr 3

CXCL12 drives natural variation in coronary artery anatomy across diverse populations: Cell www.cell.com/cell/fulltex...

CXCL12 drives natural variation in coronary artery anatomy across diverse populations

Coronary dominance is a clinically important developmental phenotype that dictates whether the left or right coronary arteries perfuse the back of the heart. Genome-wide association studies and downst...

www.cell.com

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Valentina Lo Sardo @valels.bsky.social · Mar 30

This work is led by my first brave PhD student, Elsa Salido
@uwgenetics @UWCVRC with contributions from many in the lab who helped finalize this story. Grateful for the contribution of our fantastic collaborators @clintomics.bsky.social and Jose Verdezoto Mosquera

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Valentina Lo Sardo @valels.bsky.social · Mar 30

Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...

9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State | Arteriosclerosis, Thrombosis, and Vascular Biology

BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human genomic loci linked to coronary artery disease susceptibility. Among these genomic regions, the most i...

www.ahajournals.org

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Valentina Lo Sardo @valels.bsky.social · Mar 25

Congrats to @andreagalmozzi.bsky.social lab for this great study just out in @natmetabolism.bsky.social!! I’m a proud colleague, partner and wife!! ❤️❤️❤️

Andrea Galmozzi @andreagalmozzi.bsky.social · Mar 25

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

Dylan Duerre @dylanduerre.bsky.social · Mar 25

Excited to share that work from my PhD is now available in @natmetabolism.bsky.social! Here, we uncover a link between heme production, BCAA metabolism, and thermogenesis—implicating heme synthesis in #aging, #obesity, and #T2D.

Link to paper: urldefense.com/v3/__https:/...

A Thread (1/15)

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Reposted by Valentina Lo Sardo

Eric Topol @erictopol.bsky.social · Mar 1

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

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Valentina Lo Sardo @valels.bsky.social · Jan 9

👏🏻👏🏻👏🏻

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Reposted by Valentina Lo Sardo

Eric Topol @erictopol.bsky.social · Jan 8

A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com
For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...

A foundation model of transcription across human cell types - Nature

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

www.nature.com

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Valentina Lo Sardo @valels.bsky.social · Dec 18

I guess I’ll congratulate you here as well!! Great work Clint!!! Bravo😁🍾

Valentina Lo Sardo @valels.bsky.social · Dec 17

I’ll post it here as well!! Celebrations are never enough 😁! Congratulations Mete!!

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Valentina Lo Sardo @valels.bsky.social · Dec 14

🤩❤️ Beautiful atlas of vascular cells in the human body! www.nature.com/articles/s41...

An organotypic atlas of human vascular cells - Nature Medicine

A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

www.nature.com