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Aaron Ring

@aaronmring.bsky.social

1.5K followers 220 following 17 posts

Associate Professor and Anderson Family Chair of Immunotherapy, Fred Hutchinson Cancer Center Studying #cytokines, (auto)antibodies, and #cancerimmunotherapy. Founder: Simcha Tx, Seranova Bio, & Stipple Bio

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Aaron Ring @aaronmring.bsky.social · Jul 24

I am not active on Bluesky, but wanted to share the Tweetorial about our paper about autoantibodies in cancer immunotherapy that came out yesterday in Nature in case anyone wanted a speedrun.

Paper link: www.nature.com/articles/s41...

Thread: x.com/aaronmring/s...

Aaron Ring on X: "T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below https://t.co/VgTByRKRCX https://t.co/74qbyuU3hD" / X

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below https://t.co/VgTByRKRCX https://t.co/74qbyuU3hD

Aaron Ring @aaronmring.bsky.social · Apr 30

You're welcome! Let me know if you need any help setting up a project.

Aaron Ring @aaronmring.bsky.social · Apr 29

Ready to start designing some proteins? The door’s open at ariax.bio. If you have question or feedback, please drop a reply or hop in our Discord (discord.com/invite/Q7SnV...).

Ariax.bio - Democratizing Protein Design

Computationally design de novo protein binders with BindCraft and instant GPU access. No queues, no quotas, and no strings attached.

Aaron Ring @aaronmring.bsky.social · Apr 29

Cost? A typical 100-binder miniprotein design run takes 24–72 GPU-hours. That ends up being ~$100–$500 depending on the size of your target and design settings. Compare that to a mouse hybridoma campaign at a CRO, which can cost >$10,000 and drag on for months.

Aaron Ring @aaronmring.bsky.social · Apr 29

Here is what it looks in action. From the landing page, you can start designing in under a minute. It took just 52 seconds for this job to create miniprotein antagonists against CD122 (IL2Rβ).

Aaron Ring @aaronmring.bsky.social · Apr 29

Ariax removes that friction. Open the site, fill in a short form, and click start. We spin up a GPU in seconds, stream results back to a private cloud folder, and shut everything down when the job’s done. You only pay for compute—about 40 % less than AWS.

Aaron Ring @aaronmring.bsky.social · Apr 29

Still, for many researchers, these incredible tools are out of reach. They use powerful GPUs that most of us don’t have and complex command-line gymnastics over SSH.

Aaron Ring @aaronmring.bsky.social · Apr 29

BindCraft deserves special credit. @martinpacesa.bsky.social in Bruno Correia's group stitched the whole pipeline together: hallucinate, refine, score. It keeps winning Adaptyv Bio's design challenges and has become the go-to in my own lab. That’s the engine inside Ariax.

Aaron Ring @aaronmring.bsky.social · Apr 29

Computational protein design capabilities have exploded over the past few years. Tools like RFdiffusion, ProteinMPNN, ColabDesign, and BindCraft have changed the game. Success rates for miniprotein binder campaigns now approach 100%.

Aaron Ring @aaronmring.bsky.social · Apr 29

You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unveiling with @ariaxbio.bsky.social today.

Reposted by Aaron Ring

Thomas Hart @tmhartbio.bsky.social · Mar 26

Happy to share our new ScienceTM paper from Yingjun Cui, Erol Fikrig and @aaronmring.bsky.social et al. We built a yeast display library of 3,000+ I. scapularis proteins to profile antigens recognized by tick-resistant hosts, and developed a new anti-tick vaccine. www.science.org/doi/10.1126/...

Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans

Comprehensive profiling of Ixodes scapularis antigens reveals that tick bites induce antivector immunity linked to acquired tick resistance.

www.science.org

Reposted by Aaron Ring

Tcellogic (Sue Kaech) @tcellogic.bsky.social · Nov 23

To get started we have a lot of new discoveries coming out of the lab!!

Aaron Ring @aaronmring.bsky.social · Nov 19

Welcome Scott! Good to see another TST colleague from @fredhutch.bsky.social here.

Aaron Ring @aaronmring.bsky.social · Nov 19

Please make one!

Aaron Ring @aaronmring.bsky.social · Nov 18

Aaron Ring @aaronmring.bsky.social · Nov 18

I'm with Jony on this... I miss early Twitter when the feed was 100% cool science. It was such a cheat code! I hope bluesky can recreate that vibe. OFC if we want to get depressed/pissed off Twitter still exists...

Aaron Ring @aaronmring.bsky.social · Nov 18

Yes please!!!

Aaron Ring @aaronmring.bsky.social · Nov 17

Deleting will make it harder for people migrating here to find you. Also loss of valuable content. Why delete? Makes no sense.

Aaron Ring @aaronmring.bsky.social · Nov 16

Thank you Mikki