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Adam Pennycuick @adampennycuick.bsky.social · Jun 30

AlphaMissense promises powerful AI for pathogenic variant identification. Is it clinically useful? Smart validation approach here against known signatures ascopubs.org/doi/10.1200/... Found with researchbriefing.com

ascopubs.org

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Adam Pennycuick @adampennycuick.bsky.social · Jun 27

Could we “see” intratumoral CD4 cells in vivo with PET? That’s the promise of this novel tracer. Very cool if it works www.science.org/doi/10.1126/... Found with researchbriefing.com

www.science.org

Adam Pennycuick @adampennycuick.bsky.social · Jun 12

Night shifts increase lung cancer risk - and there's more to it than smoking. Very interesting BioBank analysis here academic.oup.com/sleep/advanc.... Found with researchbriefing.com

Adam Pennycuick @adampennycuick.bsky.social · Jun 11

Immunotherapy tox is not always bad; can lead to better outcomes. More data on this in the post-CRT NSCLC setting bmcpulmmed.biomedcentral.com/articles/10.... Found with researchbriefing.com

Impact of irae characteristics on efficacy of consolidative immunotherapy following chemoradiotherapy in locally advanced NSCLC - BMC Pulmonary Medicine

Background Consolidative PD-L1 inhibitors after concurrent chemoradiotherapy (cCRT) have become standard care in locally advanced non-small cell lung cancer (LA-NSCLC). However, the correlation…

bmcpulmmed.biomedcentral.com

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Adam Pennycuick @adampennycuick.bsky.social · Jun 10

This is a compelling vision of how AI agents will improve our treatment decisions in future www.nature.com/articles/s43.... Impressive progress but still a way from the clinic. Found with researchbriefing.com

Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology - Nature Cancer

Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various clinical scenarios…

www.nature.com

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Adam Pennycuick @adampennycuick.bsky.social · Jun 9

I’ve always struggled with dermatology. Never good at identifying skin problems. Now AI can do it for us, and better www.nature.com/articles/s41... - need this in EPIC ASAP! Found with researchbriefing.com

A multimodal vision foundation model for clinical dermatology - Nature Medicine

Trained on large and multicenter datasets with different imaging modalities, a foundation model is shown to have strong performance on the full spectrum of clinically relevant tasks and to increase…

www.nature.com

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Adam Pennycuick @adampennycuick.bsky.social · Jun 3

First line ipi nivo for mNSCLC. 19% still responding at 6y. We don’t use this combo but I’m sure there are some patients who would benefit, if we could target them better www.esmoopen.com/article/S205... Found with researchbriefing.com

www.esmoopen.com

Adam Pennycuick @adampennycuick.bsky.social · Jun 2

Cancers are complex. This study shows moving from simple biomarkers to more complex models can improve outcomes www.nature.com/articles/s41... Found with researchbriefing.com

Real-world performance analysis of a universal computational reasoning model for precision oncology in lung cancer - npj Precision Oncology

npj Precision Oncology - Real-world performance analysis of a universal computational reasoning model for precision oncology in lung cancer

www.nature.com

Adam Pennycuick @adampennycuick.bsky.social · May 20

Patients with COPD do better on immunotherapy www.nature.com/articles/s41... Found with researchbriefing.com

COPD patients with non-small cell lung cancer respond better to anti-PD-(L)1 immune checkpoint inhibitors - Scientific Reports

Scientific Reports - COPD patients with non-small cell lung cancer respond better to anti-PD-(L)1 immune checkpoint inhibitors

www.nature.com

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Adam Pennycuick @adampennycuick.bsky.social · May 14

In genomics we tend to think in 1D sequences. Great study shows we need think in 3D www.nature.com/articles/s41... Found with researchbriefing.com

Three-dimensional genome landscape of primary human cancers - Nature Genetics

This study characterizes the three-dimensional (3D) genome architecture of 15 primary human cancer types from The Cancer Genome Atlas. The analyses identify different archetypes of enhancer usage and…

www.nature.com

Adam Pennycuick @adampennycuick.bsky.social · May 13

How old you look is a better predictor of outcome than how old you are. Another smart AI application shows prognostic value of FaceAge predictor in cancer patients buff.ly/e275kVV Found with researchbriefing.com

www.thelancet.com

Adam Pennycuick @adampennycuick.bsky.social · May 12

Spatial profiling of precancerous lung lesions identifies TIM3 as a potential interception target www.sciencedirect.com/science/arti.... Fantastic study. Found with researchbriefing.com

www.sciencedirect.com

Adam Pennycuick @adampennycuick.bsky.social · Apr 30

Can we improve immunotherapy responses by depleting regulatory T-cells? Encouraging data in GBM www.cell.com/immunity/ful... Found with researchbriefing.com

www.cell.com

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Adam Pennycuick @adampennycuick.bsky.social · Apr 29

Can we predict patient outcomes by… asking them? Longitudinal analysis of PRO data suggests we can aacrjournals.org/clincancerre... Found with researchbriefing.com

aacrjournals.org

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Adam Pennycuick @adampennycuick.bsky.social · Apr 28

Love this use of AI. Reviewed >600k oncology patient messages to find their main care issues. Great to focus future improvements jamanetwork.com/journals/jam... Found with researchbriefing.com

jamanetwork.com

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Adam Pennycuick @adampennycuick.bsky.social · Apr 25

Clonal haematopoeisis; important in ageing and now associated with worse outcomes when infiltrating tumours. More great work from the TRACERx team www.nejm.org/doi/10.1056/... Found with researchbriefing.com

www.nejm.org

Adam Pennycuick @adampennycuick.bsky.social · Apr 24

In scRNAseq how do you find tumour cells? This approach makes sense to me, using CNA profiles inferred from the transcriptome academic.oup.com/bib/article/... Found with researchbriefing.com

academic.oup.com

Adam Pennycuick @adampennycuick.bsky.social · Apr 23

Antibiotics can affect immunotherapy efficacy via the microbiome. Should be used with caution. Helpful and detailed guide: ascopubs.org/doi/10.1200/... Found with researchbriefing.com

ascopubs.org

Adam Pennycuick @adampennycuick.bsky.social · Apr 14

Adding RT to peri-op chemoIO improves MPR but not OS/PFS www.jto.org/article/S155... Found with researchbriefing.com

www.jto.org

Adam Pennycuick @adampennycuick.bsky.social · Apr 8

MetaGP - medical foundation model improves diagnostic performance of doctors buff.ly/WzRk39a Found with researchbriefing.com

www.sciencedirect.com

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Adam Pennycuick @adampennycuick.bsky.social · Apr 7

But previous neoadj osimertinib trial declared a failure due to low MPR rate buff.ly/AAyHQO1. Similar MPR rates in both. Good lesson to focus on the endpoint that matters most. Both found with researchbriefing.com

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Adam Pennycuick @adampennycuick.bsky.social · Apr 7

This got me thinking about neoadjuvant trial design. Phase II neoadj EGFR inhibitor declared a success due to high conversion rate to resectability in unresectable stage III disease www.nature.com/articles/s41... (1/2)

Neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant non-small cell lung cancer: a single-arm phase II trial - Nature Communications

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2…

buff.ly

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Adam Pennycuick @adampennycuick.bsky.social · Apr 4

Exosomes are definitely interesting for early cancer detection. AI-powered exosome detection using microfluidics seems like a smart approach buff.ly/rKqTrXu Found with researchbriefing.com

pubs.acs.org

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Adam Pennycuick @adampennycuick.bsky.social · Apr 3

Can LLMs design proteins now? Enzymes designed with natural language prompts... incredible... buff.ly/nSvYH9Z Found with researchbriefing.com

Toward De Novo Protein Design from Natural Language

De novo protein design represents a fundamental pursuit in protein engineering, yet current deep learning approaches remain constrained by their narrow design scope. Here we present Pinal, a…

www.biorxiv.org

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Adam Pennycuick @adampennycuick.bsky.social · Apr 2

People at germline risk of autoimmune diseases also at risk of ICI tox. Makes sense - could lead to better personalisation in future buff.ly/qj0KnOh Found with researchbriefing.com

Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events

Introduction Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors, but they also commonly cause immune-related adverse events (irAEs).…

jitc.bmj.com

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