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agingbiology.bsky.social
Aging Science News
@agingbiology.bsky.social
66 followers 1 following 520 posts
Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research.
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agingbiology.bsky.social
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma
link.springer.com/article/10.1...
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma - Discover Oncology
Background Skin cutaneous melanoma (SKCM) is the deadliest skin cancer, with rising global incidence. Cellular senescence plays an essential role in tumorigenesis, progression, and immune modulation i...
link.springer.com
November 26, 2025 at 2:48 PM
agingbiology.bsky.social
Boy with rare condition amazes doctors after world-first gene therapy
www.bbc.com/news/article...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy
Oliver has an inherited condition called Hunter syndrome, which causes progressive damage to the body and brain.
www.bbc.com
November 26, 2025 at 1:26 AM
agingbiology.bsky.social
Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice
www.ibroneuroreports.org/article/S266...
Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice
Brain aging is characterized by progressive structural and functional deterioration, leading to cognitive decline and impaired social functioning. A key factor in this process is the age-related decli...
www.ibroneuroreports.org
November 25, 2025 at 10:48 PM
agingbiology.bsky.social
Obesity jab drug fails to slow Alzheimer's
www.bbc.com/news/article...
Obesity drug semaglutide fails to slow Alzheimer's
There were initial hopes that the drug in weight loss jab Wegovy could slow progression of dementia.
www.bbc.com
November 25, 2025 at 4:55 PM
agingbiology.bsky.social
Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain
onlinelibrary.wiley.com/doi/full/10....
Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain
Our single nuclei RNA sequencing data reveal that long-term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restricti....
onlinelibrary.wiley.com
November 25, 2025 at 3:42 PM
agingbiology.bsky.social
Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches
www.annualreviews.org/content/jour...
Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches
Aging research relies on varied statistical methods, and applying these methods appropriately is important for scientific rigor. However, proper use of these statistical techniques is a challenge. We ...
www.annualreviews.org
November 24, 2025 at 10:46 PM
agingbiology.bsky.social
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
www.biorxiv.org/content/10.1...
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
Decades of publicly available molecular studies have generated millions of samples testing diverse interventions, yet these datasets were rarely analyzed for their effects on aging. Aging clocks now e...
www.biorxiv.org
November 24, 2025 at 3:46 PM
agingbiology.bsky.social
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis
www.thelancet.com/journals/ebi...
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis
SSK1 is an effective candidate for senolytics in alleviating OA. The anti-ageing therapeutic effect of SSK1 lies in restoring a regenerative phenotype by improving the proliferation microenvironment, ...
www.thelancet.com
November 23, 2025 at 11:49 PM
agingbiology.bsky.social
Drug-mediated disruption of the aging gut microbiota and mucosal immune system
www.frontiersin.org/journals/agi...
Frontiers | Drug-mediated disruption of the aging gut microbiota and mucosal immune system
The human gut microbiota is comprised predominantly of bacteria, and also includes archaea, fungi, and viruses. The gastrointestinal epithelium, mucosal barr...
www.frontiersin.org
November 23, 2025 at 5:58 PM
agingbiology.bsky.social
DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
November 23, 2025 at 3:19 PM
agingbiology.bsky.social
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
www.thelancet.com/journals/lan...
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
Higher GrimAge EAA is consistently associated with higher frailty. Future research should focus on developing and validating DNA methylation clocks that integrate molecular surrogates of health risk a...
www.thelancet.com
November 23, 2025 at 12:43 AM
agingbiology.bsky.social
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency
www.pnas.org/doi/10.1073/...
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency | PNAS
Intercellular mitochondrial transfer, the spontaneous exchange of mitochondria between cells, is a recently described phenomenon crucial for cellul...
www.pnas.org
November 22, 2025 at 10:27 PM
agingbiology.bsky.social
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques
www.nature.com/articles/s41...
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques - Nature Methods
This Resource provides a multi-omic tissue atlas of aging in nonhuman primates.
www.nature.com
November 22, 2025 at 3:08 PM
agingbiology.bsky.social
Increased genetic protection against Alzheimer’s disease in centenarians
link.springer.com/article/10.1...
Increased genetic protection against Alzheimer’s disease in centenarians - GeroScience
We constructed a polygenic protective score specific to Alzheimer’s disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longev...
link.springer.com
November 22, 2025 at 1:28 PM
agingbiology.bsky.social
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming
translational-medicine.biomedcentral.com/articles/10....
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming - Journal of Translational Medicine
Cellular senescence is a fundamental driver of ageing and age-related diseases, characterized by irreversible growth arrest and profound epigenetic alterations. While long non-coding RNAs (lncRNAs) ha...
translational-medicine.biomedcentral.com
November 21, 2025 at 11:19 PM
agingbiology.bsky.social
An atlas of mitochondrial ATP synthase activity across the lifespan
www.sciencedirect.com/science/arti...
An atlas of mitochondrial ATP synthase activity across the lifespan
Mitochondrial dysfunction and declining energy production are hallmarks of aging, yet we lack a comprehensive systems-level view of ATP synthase (Comp…
www.sciencedirect.com
November 21, 2025 at 3:14 PM
agingbiology.bsky.social
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
link.springer.com/article/10.1...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function - Biogerontology
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied hi...
link.springer.com
November 20, 2025 at 11:43 PM
agingbiology.bsky.social
Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication
www.sciencedirect.com/science/arti...
Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication
Mitochondrial dysfunction is a central driver of cellular senescence, a core hallmark of aging. While intrinsic mechanisms have been extensively revie…
www.sciencedirect.com
November 20, 2025 at 7:31 PM
agingbiology.bsky.social
Inflammasome activation and accelerated immune aging in autoimmune disorders
www.frontiersin.org/journals/agi...
Frontiers | Inflammasome activation and accelerated immune aging in autoimmune disorders
Autoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are parado...
www.frontiersin.org
November 20, 2025 at 5:15 PM
agingbiology.bsky.social
Body-wide multi-omic counteraction of aging with GLP-1R agonism
www.cell.com/cell.../full...
Body-wide multi-omic counteraction of aging with GLP-1R agonism
GLP-1R agonism counteracts body-wide aging in a brain-dependent manner, mimicking the molecular effects of mTOR inhibition.
www.cell.com
November 20, 2025 at 1:06 PM
agingbiology.bsky.social
Things you can do in your 30s to improve your health in your 70s
www.bbc.com/future/artic...
Things you can do in your 30s to improve your health in your 70s
From a brisk 15-minute walk, to getting regular sleep – doing these things in your 30s could help you stay fit well into your 70s.
www.bbc.com
November 19, 2025 at 11:28 PM
agingbiology.bsky.social
A scalable step count-based predictor of biological age: development and validation of MoveIt! Age in community-dwelling adults and geriatric rehabilitation inpatients
link.springer.com/article/10.1...
A scalable step count-based predictor of biological age: development and validation of MoveIt! Age in community-dwelling adults and geriatric rehabilitation inpatients - GeroScience
Measuring biological age typically requires invasive and costly procedures. To address this, the MoveIt! Age Score was developed: a simple, scalable, and interpretable aging clock that predicts biolog...
link.springer.com
November 19, 2025 at 5:36 PM
agingbiology.bsky.social
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/full/10....
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue m...
onlinelibrary.wiley.com
November 19, 2025 at 3:33 PM
agingbiology.bsky.social
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023
www.thelancet.com/journals/lan...
Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Di...
This analysis identified several key differences in mortality trends from previous estimates, including higher rates of adolescent mortality, higher rates of young adult mortality in females, and lowe...
www.thelancet.com
November 19, 2025 at 12:25 AM
agingbiology.bsky.social
In vivo evidence supports the effectiveness of the longevity-associated protein LAV-BPIFB4 in reducing adipose tissue-derived mediators of systemic inflammation to prevent vascular insult and atheromatous change
www.tandfonline.com/doi/full/10....
In vivo evidence supports the effectiveness of the longevity-associated protein LAV-BPIFB4 in reducing adipose tissue-derived mediators of systemic inflammation to prevent vascular insult and atheroma...
Obesity triggers chronic low-grade inflammation contributing to cardiovascular and metabolic diseases. Over-release of adipokines and pro-inflammatory mediators by white adipose tissue (WAT) enhanc...
www.tandfonline.com
November 18, 2025 at 7:45 PM