Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM
@agingdoc.bsky.social
Longevity medicine best practices | healthspan | precision medicine | geroscience | bio/acc | consulting @ agingdoc.com
Connect: http://linkedin.com/in/agingdoc
Connect: http://linkedin.com/in/agingdoc
Pinned
I'm honored to join Harvard Medical School as a part-time Lecturer.
If you're a colleague at @harvardmed.bsky.social working on upcoming conferences or educational initiatives across healthspan I’d welcome the opportunity to collaborate.👨⚕️
Please reach out at
🔗https://www.linkedin.com/in/agingdoc/
If you're a colleague at @harvardmed.bsky.social working on upcoming conferences or educational initiatives across healthspan I’d welcome the opportunity to collaborate.👨⚕️
Please reach out at
🔗https://www.linkedin.com/in/agingdoc/
Targeted delivery of genome editors in vivo
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
January 13, 2026 at 3:18 PM
Targeted delivery of genome editors in vivo
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
👍⚕️
January 13, 2026 at 3:17 PM
👍⚕️
My friend Andrew Steele is building this:
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
December 28, 2025 at 6:07 PM
My friend Andrew Steele is building this:
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
December 23, 2025 at 2:20 AM
This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
December 6, 2025 at 3:22 PM
Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
People often ask me the same question:
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
November 28, 2025 at 11:20 PM
People often ask me the same question:
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM on X: "Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric" / X
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric
x.com
November 19, 2025 at 12:41 AM
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
November 9, 2025 at 10:48 PM
AI Learns to Design the Human Body’s Most Elusive Proteins
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
AI Learns to Design the Human Body’s Most Elusive Proteins - Neuroscience News
A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human pro...
neurosciencenews.com
October 7, 2025 at 12:07 AM
AI Learns to Design the Human Body’s Most Elusive Proteins
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
This AI tool predicts your risk of 1,000 diseases — by looking at your medical records
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
September 30, 2025 at 11:28 AM
This AI tool predicts your risk of 1,000 diseases — by looking at your medical records
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
August 28, 2025 at 10:45 PM
@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
www.nytimes.com
August 5, 2025 at 1:22 PM
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
See you there!
August 2, 2025 at 4:05 PM
See you there!
👍
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
August 2, 2025 at 11:02 AM
👍
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
www.nytimes.com
August 2, 2025 at 10:59 AM
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
DNA Methylation Ageing Atlas Across 17 Human Tissues
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
July 28, 2025 at 9:01 PM
DNA Methylation Ageing Atlas Across 17 Human Tissues
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
Editorial: Resilience in aging
@drlaurahaynes.bsky.social and coauthors
www.frontiersin.org/journals/agi...
@drlaurahaynes.bsky.social and coauthors
www.frontiersin.org/journals/agi...
Frontiers | Editorial: Resilience in aging
In this editorial, we discuss contributions to the research topic of Resilience in Aging. Resilience refers to the capacity to recover from stress and restor...
www.frontiersin.org
July 28, 2025 at 8:52 PM
Editorial: Resilience in aging
@drlaurahaynes.bsky.social and coauthors
www.frontiersin.org/journals/agi...
@drlaurahaynes.bsky.social and coauthors
www.frontiersin.org/journals/agi...
AlphaGo Moment for Model Architecture Discovery
👉“ASI-Arch is presented, the first demonstration of Artificial Superintelligence for AI research (ASI4AI) in the critical domain of neural architecture discovery, with the first empirical scaling law for scientific discovery itself..“
t.co/ljJ1fXsslE
👉“ASI-Arch is presented, the first demonstration of Artificial Superintelligence for AI research (ASI4AI) in the critical domain of neural architecture discovery, with the first empirical scaling law for scientific discovery itself..“
t.co/ljJ1fXsslE
July 28, 2025 at 5:06 PM
AlphaGo Moment for Model Architecture Discovery
👉“ASI-Arch is presented, the first demonstration of Artificial Superintelligence for AI research (ASI4AI) in the critical domain of neural architecture discovery, with the first empirical scaling law for scientific discovery itself..“
t.co/ljJ1fXsslE
👉“ASI-Arch is presented, the first demonstration of Artificial Superintelligence for AI research (ASI4AI) in the critical domain of neural architecture discovery, with the first empirical scaling law for scientific discovery itself..“
t.co/ljJ1fXsslE
Fearful of AI-generated grant proposals, NIH limits scientists to six applications per year
Some critics of the new policy say the cap could hinder researchers in need of funding
www.science.org/content/arti...
Some critics of the new policy say the cap could hinder researchers in need of funding
www.science.org/content/arti...
Fearful of AI-generated grant proposals, NIH limits scientists to six applications per year
Some critics of the new policy say the cap could hinder researchers in need of funding
www.science.org
July 21, 2025 at 4:43 PM
Fearful of AI-generated grant proposals, NIH limits scientists to six applications per year
Some critics of the new policy say the cap could hinder researchers in need of funding
www.science.org/content/arti...
Some critics of the new policy say the cap could hinder researchers in need of funding
www.science.org/content/arti...
'They hold hands, they embrace, they kiss': The woman who changed our view of chimps - and human beings
www.bbc.com/culture/arti...
www.bbc.com/culture/arti...
'They hold hands, they embrace, they kiss': The woman who changed our view of chimps - and human beings
In 1960, Jane Goodall began her groundbreaking field study by living among chimpanzees in Tanzania. In 1986, she told the BBC how similar chimps and humans really are.
www.bbc.com
July 15, 2025 at 6:55 PM
'They hold hands, they embrace, they kiss': The woman who changed our view of chimps - and human beings
www.bbc.com/culture/arti...
www.bbc.com/culture/arti...
Just How Harmful Is Vaping? More Evidence Is Emerging.
A new study that found high levels of heavy metals in popular nicotine vapes adds to concerns about the products.
www.nytimes.com/2025/07/09/w...
A new study that found high levels of heavy metals in popular nicotine vapes adds to concerns about the products.
www.nytimes.com/2025/07/09/w...
Just How Harmful Is Vaping? More Evidence Is Emerging.
www.nytimes.com
July 9, 2025 at 2:08 PM
Just How Harmful Is Vaping? More Evidence Is Emerging.
A new study that found high levels of heavy metals in popular nicotine vapes adds to concerns about the products.
www.nytimes.com/2025/07/09/w...
A new study that found high levels of heavy metals in popular nicotine vapes adds to concerns about the products.
www.nytimes.com/2025/07/09/w...