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NEJM AI
@ai.nejm.org
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NEJM AI, a new monthly journal from the publisher of @nejm.org, explores the cutting-edge applications of artificial intelligence and machine learning in clinical medicine. Online at ai.nejm.org.
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NEJM AI @ai.nejm.org · 7d
Volume 3, No. 1 of NEJM AI is now available! Here is a preview of the latest content:

𝗘𝗱𝗶𝘁𝗼𝗿𝗶𝗮𝗹𝘀
Evolving Regulatory Science nejm.ai/4biPa3o

#MedSky #AI #MLSky
The cover of the January 2026 issue of NEJM AI with "NEW ISSUE NOW AVAILABLE" above it.
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A letter highlights the need for #AI systems that restore physician presence and align technology with human values and argues that doctors who code must focus on the 60% of clinical work lost to inefficiency and administrative burden. Full letter: nejm.ai/4sr5QMk

#MedSky #MLSky
Page 1 of "Letter: Regarding 'Humanity’s Next Medical Exam'" Bottom: Read the full letter at ai.nejm.org.
January 13, 2026 at 5:30 PM
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An #AI triage system for detecting features of lung cancer on chest x-rays across a multihospital trust in London reduced the median time from chest x-ray to CT report without increasing overall CT volume. Full study results: nejm.ai/3Ngic9T

#MedSky #MLSky
Figure 2. Flow Diagram of Patients Included and Excluded from the Study and the Results of the Diagnostic Accuracy Study.
January 13, 2026 at 2:30 PM
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Using data from hospitals in 12 countries, a new study found that #AI models trained on continual learning for assessing endotracheal tube placement on chest radiographs consistently outperformed baseline and single-hospital fine-tuned models. Learn more: nejm.ai/3KZwdbt

#MedSky #MLSky
Original Article International Retrospective Observational Study of Continual Learning for AI on Endotracheal Tube Placement from Chest Radiographs E. Chen and Others Abstract illustration of a human profile connected to digital lines against a purple and blue background with "H" symbols representing hospitals.
January 12, 2026 at 7:12 PM
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Missed findings may matter more than incidental ones. On NEJM AI Grand Rounds, Dr. Zak Kohane explains why clinicians may soon run every scan through #AI as a second set of eyes. Listen to the full episode: nejm.ai/ep37

#MedSky #MLSky
January 8, 2026 at 1:30 PM
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Volume 3, No. 1 of NEJM AI is now available! Here is a preview of the latest content:

𝗘𝗱𝗶𝘁𝗼𝗿𝗶𝗮𝗹𝘀
Evolving Regulatory Science nejm.ai/4biPa3o

#MedSky #AI #MLSky
The cover of the January 2026 issue of NEJM AI with "NEW ISSUE NOW AVAILABLE" above it.
January 6, 2026 at 2:15 PM
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Original Article by A. Bishara et al.: AI-Guided Surgical Blood Readiness: Overcoming Real-World Challenges in Prospective Validation for Safer, More Efficient Blood Preparation nejm.ai/3KAaTc9

#AI #MedSky #MLSky
Figure 1. Model Performance on Retrospective Data Test Set and Prospective Data. Figure 2. Data Dashboard Tracking Model Performance on Prospective Data Over Time. Figure 3. Smart Match Performance on Prospective Data at Different Time Points Relative to Anesthesia Start.
January 5, 2026 at 1:30 PM
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Original Article by J.B. Moody et al.: A Foundation Transformer Model with Self-Supervised Learning for ECG-Based Assessment of Cardiac and Coronary Function nejm.ai/3XvciUi

#AI #MedSky #MLSky
Figure 1. Chest Pain Encounters in the United States and Available Noninvasive Testing Modalities. Figure 2. External Tests Evaluated in the HM-PET Database. Figure 3. Additional Tests of the SSL Pretrained Model in the UM-phSPECT, UM-exSPECT, UK Biobank, and PTB-XL Databases.
January 2, 2026 at 2:30 PM
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Policy Corner by N. Razavian et al.: Catalyzing Health AI by Fixing Payment Systems nejm.ai/44DVaiY

#AI #MedSky #MLSky
Figure 1. The Timeline and Major Reimbursement Events in a Few Health AI Domains with U.S. Food and Drug Administration–Approved Products.
December 31, 2025 at 1:30 PM
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Vibe coding works, but only if you know the system. On NEJM AI Grand Rounds, Dr. Zak Kohane breaks down why domain expertise still shapes AI’s usefulness. Listen to the full episode: nejm.ai/ep37

#AI #MedSky #MLSky
December 30, 2025 at 1:30 PM
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Perspective by A. Poddar et al.: Mitigating Limited Data Challenges to Improve Artificial Intelligence Integration in Rare Disease Drug Development nejm.ai/4peikVF

#AI #MedSky #MLSky
Figure 1. Approaches to Enhance the Application of Artificial Intelligence in Drug Development for Rare Diseases.
December 29, 2025 at 2:30 PM
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Review Article by Soojin Park, MD, Yanwei Li, MS, and Murad Megjhani, PhD: Physiological Signals Boosted by Artificial Intelligence Save Time and Brain Function nejm.ai/4pu5OBD

#AI #MedSky #NeuroSky
Figure 1. Physiological Device Data Sources for Machine Learning Applications in Neurocritical Care. Figure 2. Case 1: Computed Tomography Scan of the Brain on Admission Showing Thick Diffuse Blood (A), Intraventricular Hemorrhage (B), and Hydrocephalus (C). Figure 3. Case 1: Postbleed Day 3.
December 26, 2025 at 1:45 PM
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#AI turned hours into minutes. Dr. Zak Kohane describes how he built his own EHR — showing clinicians what true augmentation looks like on NEJM AI Grand Rounds. Hear more from Dr. Kohane: nejm.ai/ep37

#MedSky #MLSky
December 25, 2025 at 1:30 PM
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A new article presents the development and silent prospective validation of Smart Match, a machine-learning system designed to predict patient-specific perioperative blood transfusion needs. Learn more about this system: nejm.ai/3KAaTc9

#AI #MedSky #MLSky
Figure 3. Smart Match Performance on Prospective Data at Different Time Points Relative to Anesthesia Start.
December 24, 2025 at 1:30 PM
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A new study introduces a self-supervised electrocardiogram transformer foundation model that achieves high diagnostic accuracy across multiple cardiac prediction tasks, expanding AI’s potential in complex diagnostic areas. Learn more: nejm.ai/3XvciUi

#AI #MedSky #MLSky
Figure 1. Chest Pain Encounters in the United States and Available Noninvasive Testing Modalities.
December 23, 2025 at 2:30 PM
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Original Article by P.J. Lukac et al.: Ambient AI Scribes in Clinical Practice: A Randomized Trial nejm.ai/3MwD0cJ 

#AI #MedSky #MLSky
Figure 1. CONSORT-AI Flow Diagram
December 22, 2025 at 6:26 PM
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Perspective by Bilal Irfan, MS, J. Wesley Boyd, MD, PhD, and Roberto Daniel Sirvent, JD, PhD: When Protecting Privacy Means Protecting Health: Foreseeable Health Harms of AI Language Translation and Interpretation Technologies for Immigrant Patients nejm.ai/49PrjYr

#AI #MedSky #MLSky
Page 1 of the Perspective "When Protecting Privacy Means Protecting Health: Foreseeable Health Harms of AI Language Translation and Interpretation Technologies for Immigrant Patients" Read the full article at ai.nejm.org.
December 22, 2025 at 2:01 PM
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Editorial by A.K. Manrai et al.: Accelerating Science with Human+AI Review nejm.ai/4rut6bD

#AI #MedSky #MLSky
Page 1 of the editorial "Accelerating Science with Human+AI Review" Read the full editorial at ai.nejm.org.
December 19, 2025 at 8:13 PM
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Policy Corner by A. Poddar et al.: Leveraging Artificial Intelligence in Drug and Biological Product Development: An FDA and Clinical Trial Transformation Initiative Workshop Report nejm.ai/4piY05C

#AI #MedSky #MLSky
Figure 1. Challenges Associated with the Integration of AI Technology in Drug Development. Figure 2. Recommended Next Steps for the Interested Parties to Successfully Integrate AI in Drug Development.
December 19, 2025 at 2:40 PM
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Editorial by Eileen Kim, MD, Vincent X. Liu, MD, MSc, and Karandeep Singh, MD, MMSc: AI Scribes Are Not Productivity Tools (Yet) nejm.ai/48aLhvx

@kdpsingh.bsky.social #AI #MedSky #MLSky
Page 1 of the editorial "AI Scribes Are Not Productivity Tools (Yet)" Read the full editorial at ai.nejm.org.
December 18, 2025 at 5:20 PM
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This article analyzes how current reimbursement mechanisms hinder the adoption of clinically effective and regulated #AI tools in health care, despite rapid technological progress. Read the full article: nejm.ai/44DVaiY

#MedSky #MLSky
Figure 1. The Timeline and Major Reimbursement Events in a Few Health AI Domains with U.S. Food and Drug Administration–Approved Products.
December 18, 2025 at 1:40 PM
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Original Article by M. Afshar et al.: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being nejm.ai/4onek3X

@majeans2011.bsky.social #AI #MedSky #MLSky
Figure 2. Trial-Averaged Effect of Ambient AI on Primary Outcome of Professional Well-Being (Subcomponents with Professional Fulfillment and Work Exhaustion/Interpersonal Disengagement [Burnout]). Figure 3. Forest Plot for Time-on-Treatment Effect on Primary Outcome of Professional Well-Being (Subcomponents of Professional Fulfillment and Burnout).
December 17, 2025 at 6:41 PM
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In the latest episode of the AI Grand Rounds podcast, Dr. Zak Kohane, editor-in-chief of NEJM AI, explains why this year’s advances in #AI were personal, why it’s spreading fast, and why its most profound theme is values. Full episode: nejm.ai/ep37

#MedSky #MLSky
AI Grand Rounds Episode 37 What Values Are in AI? A Conversation with Dr. Zak Kohane A photo of Dr. Kohane
December 17, 2025 at 3:30 PM
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In a new trial evaluating two LLM-powered ambient #AI scribes on a sample of 238 outpatient physicians, one of the tools modestly reduced the time spent writing notes, while both showed potential to improve burnout and task load. Full trial results: nejm.ai/3MwD0cJ

#MedSky #MLSky
Figure 1. CONSORT-AI Flow Diagram
December 16, 2025 at 5:29 PM
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A new Perspective examines the unique challenges of drug development for rare, ultrarare, and hyper-rare diseases, and it highlights strategies to address these obstacles with the advent of AI. Read the full Perspective: nejm.ai/4peikVF

#AI #MedSky #MLSky
“More focused collaborative efforts will be essential to address the unique scientific, regulatory, and policy issues associated with the integration of AI into the rare disease space in order to expand the number of effective therapeutic options for patients.” Perspective “Mitigating Limited Data Challenges to Improve Artificial Intelligence Integration in Rare Disease Drug Development” by A. Poddar et al.
December 16, 2025 at 3:39 PM
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The authors of a new editorial describe the invitation-only “Fast Track” process used to review two trials of ambient AI scribes and emphasize the central role of human judgment and values while using AI to accelerate science. Full editorial: nejm.ai/4rut6bD

#AI #MedSky #MLSky
“We are encouraged by our first experiences using AI to generate reviews for NEJM AI articles and are proud to publish both randomized controlled trials by Afshar et al. and Lukac et al.” Editorial “Accelerating Science with Human+AI Review” by A.K. Manrai et al.
December 15, 2025 at 6:33 PM