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Andrew Bass @ajbass.bsky.social · Aug 25

Software: github.com/ajbass/sffdr

GitHub - ajbass/sffdr: Pleiotropy-informed significance analysis with functional false discovery rates

Pleiotropy-informed significance analysis with functional false discovery rates - ajbass/sffdr

github.com

Andrew Bass @ajbass.bsky.social · Aug 25

Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs.

Paper: www.nature.com/articles/s43...

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates - Nature Computational Science

This study introduces a cost-effective strategy called surrogate functional false discovery rates to increase power in genome-wide association studies by leveraging genetic correlations (or pleiotropy...

www.nature.com

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medRxivpreprint @medrxivpreprint.bsky.social · Sep 26

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1

The cost of acquiring participants for genome-wide association studies (GWAS) can limit sample sizes

www.medrxiv.org

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Dec 3

A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1

Differential co-expression analysis (DCA) aims to identify genes in a pathway whose shared expressio

www.biorxiv.org

Andrew Bass @ajbass.bsky.social · Dec 4

We have software you can use on GitHub: github.com/ajbass/kdca. Work with @epsteinstatgen.bsky.social and @davecutler.bsky.social.

GitHub - ajbass/kdca: Kernel-based Differential Co-expression Analysis

Kernel-based Differential Co-expression Analysis. Contribute to ajbass/kdca development by creating an account on GitHub.

github.com

Andrew Bass @ajbass.bsky.social · Dec 4

Differential co-expression arises from shared unmodeled biological variation involving an observed risk factor and an unobserved (or latent) factor. We developed a method to detect such variation in a pathway for general gene expression studies!

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Dec 3

A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1

Differential co-expression analysis (DCA) aims to identify genes in a pathway whose shared expressio

www.biorxiv.org

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Andrew Bass @ajbass.bsky.social · Sep 28

New work with @chr1sw.bsky.social on increasing GWAS power by leveraging summary statistics of related traits! Package available at github.com/ajbass/sffdr.

medRxivpreprint @medrxivpreprint.bsky.social · Sep 26

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1

The cost of acquiring participants for genome-wide association studies (GWAS) can limit sample sizes

www.medrxiv.org

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Emory Department of Human Genetics @emorygenetics.bsky.social · May 2

New publication from @epsteinstatgen.bsky.social's crew describing LIT; a kernel method to map genetic variants with interaction effects on multiple phenotypes in biobanks - in Genome Medicine genomemedicine.biomedcentral.com/articles/10....

Identifying latent genetic interactions in genome-wide association studies using multiple traits - Genome Medicine

The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a n...

genomemedicine.biomedcentral.com

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Andrew Bass @ajbass.bsky.social · Sep 13

A preprint of my first post-doc paper w/ Shijia Bian, Aliza Wingo, Thomas Wingo, David Cutler and @epsteinstatgen.bsky.social is out!
www.biorxiv.org/content/10.1...

Identifying latent genetic interactions in genome-wide association studies using multiple traits

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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