Invasive fungal infections caused by pathogenic yeasts are an escalating global health crisis that demands urgent attention within a One Health framework. Th...

A systematic review and meta-analysis of clinical trials investigating the efficacy and safety of obesity management medications reported tirzepatide and semaglutide to be the most effective in reducing body weight and obesity-related complications.

npj Antimicrobials and Resistance - The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome

Capsule-specific human monoclonal antibodies are protective against bloodstream infection by Klebsiella pneumoniae sequence type 147 in a mouse model of septicaemia, and could provide a useful strategy against pathogens with antimicrobial resistance.

In a prospective study enrolling 1,222 patients from 22 emergency departments, a device using a machine-learning-based signature of blood mRNAs demonstrated clinically acceptable performance to diagnose bacterial and viral infections and to predict the all-cause need for critical care interventions within 7 days, with benchmark to established biomarkers and risk scores.

Although maternal antenatal corticosteroid treatment (ACT) improves outcomes of infants born preterm, it is associated with an increased risk of infectious diseases during infancy and early childhood....

AbstractBackground and objectives. New antibiotics effective against carbapenem-resistant Enterobacterales (CRE) provide additional treatment options, but

AbstractBackground. Recipients of allogeneic haematopoietic cell transplant (alloHCT) are at risk of multiple viral infections. However, our knowledge abou

To map funding flows in infectious disease randomized clinical trials (RCTs) by examining relationships between funding sources and trial locations in high impact journals.

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Purpose of Review Urinary tract infections (UTIs) are among the most prevalent infections worldwide, disproportionately affecting women. A considerable number of cases are classified as complicated UTIs, with catheter-associated urinary tract infections (CAUTIs) representing the most common subset. While bacterial pathogens are the predominant causative agents, Candida species have increasingly emerged as significant contributors to CAUTIs, particularly in vulnerable populations such as the elderly and immunocompromised patients. This review aims to explore the epidemiology, pathogenesis, and clinical implications of Candida-related CAUTIs. Recent Findings Candida species involved in CAUTIs exhibit multiple virulence factors, including biofilm formation, morphogenic transitions, and adhesion to catheter surfaces. Furthermore, the increasing emergence of strains with intrinsic or acquired resistance to antifungal agents—such as Candidozyma auris—has complicated management strategies. Recent studies highlight the growing burden of fungal CAUTIs and the inadequacy of current monotherapeutic approaches, prompting the investigation of novel antifungal agents, catheter modifications, and nanomaterial-based interventions. Summary Candida-associated CAUTIs represent a growing clinical challenge due to rising antifungal resistance and limited therapeutic options. Effective management requires a multifaceted approach that includes improved diagnostic tools, antifungal stewardship, innovative prevention strategies, and continued research into novel antifungal therapies and catheter technologies. Addressing these issues is critical to reducing the healthcare burden imposed by CAUTIs globally.

AbstractBackground. Aztreonam/avibactam is a novel β-lactam/β-lactamase inhibitor (BL/BLI) combination active against carbapenem-resistant Enterobacterales

SUMMARYThe bacterial species covered in this review are taxonomically diverse. Kingella kingae, a well-known infectious agent of pediatric bacteremia and osteomyelitis as well as septic arthritis in c...

The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

Enmetazobactam, taniborbactam, and zidebactam are novel β-lactamase inhibitors that have been combined with cefepime in an effort to overcome common and emerging mechanisms of antimicrobial resista...

AbstractBackground. Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clin

MAM01 was well tolerated, met safety targets, and showed clinical proof-of-principle by eliciting protection in malaria-naive adults using the controlled human malaria infection model. Progress drivin...