Amesh Adalja
@ameshaa.bsky.social
Infectious Disease • Critical Care • EM Physician
Independent voice on outbreaks, biosecurity & biothreat preparedness
Pittsburgh • NYC
Independent voice on outbreaks, biosecurity & biothreat preparedness
Pittsburgh • NYC
“According to media reports, there may be an additional three deaths not yet lab confirmed associated with this outbreak” www.cidrap.umn.edu/marburg/ethi...
Ethiopia’s Marburg death toll rises to 5
The WHO says the source of the outbreak has not yet been identified.
www.cidrap.umn.edu
November 25, 2025 at 10:39 PM
“According to media reports, there may be an additional three deaths not yet lab confirmed associated with this outbreak” www.cidrap.umn.edu/marburg/ethi...
“The document outlines strategic priorities and concrete actions across five key domains: prevention and response; monitoring and surveillance; research and innovation; laboratory capacity; and governance.” www.cidrap.umn.edu/antimicrobia...
New WHO framework aims to tackle rising resistance to HIV, STI, and hepatitis treatments
Officials warn rising drug resistance could undo decades of progress in controlling HIV, hepatitis, and sexually transmitted infections.
www.cidrap.umn.edu
November 25, 2025 at 10:38 PM
“The document outlines strategic priorities and concrete actions across five key domains: prevention and response; monitoring and surveillance; research and innovation; laboratory capacity; and governance.” www.cidrap.umn.edu/antimicrobia...
“By the time most cities introduced indoor vaccine mandates, vaccination rates were already high, and many unvaccinated individuals were deeply hesitant or resistant, leaving limited room for further gains.”
www.cidrap.umn.edu/covid-19/est...
www.cidrap.umn.edu/covid-19/est...
Estimate: US city-level COVID indoor vaccine mandates had uneven, marginal effects
The requirements didn't increase weekly vaccination rates or cut cases and deaths in adults or children, despite their success in other countries.
www.cidrap.umn.edu
November 25, 2025 at 10:37 PM
“By the time most cities introduced indoor vaccine mandates, vaccination rates were already high, and many unvaccinated individuals were deeply hesitant or resistant, leaving limited room for further gains.”
www.cidrap.umn.edu/covid-19/est...
www.cidrap.umn.edu/covid-19/est...
“Short of developing a universal influenza vaccine with effectiveness that spans multiple seasons and influenza subtypes, the development of seasonal influenza vaccines with improved effectiveness would constitute an important public health advance,” www.cidrap.umn.edu/influenza-va...
Experimental mRNA flu vaccine shows superior efficacy against symptomatic illness
www.cidrap.umn.edu
November 25, 2025 at 10:36 PM
“Short of developing a universal influenza vaccine with effectiveness that spans multiple seasons and influenza subtypes, the development of seasonal influenza vaccines with improved effectiveness would constitute an important public health advance,” www.cidrap.umn.edu/influenza-va...
“The number needed to harm for acute respiratory failure was 4,976 for the TMP-SMX versus amoxicillin cohort and 4,046 for the TMP-SMX versus cephalosporins cohort.” www.cidrap.umn.edu/antimicrobia...
Common antibiotic linked to risk of acute respiratory failure in kids, young adults
www.cidrap.umn.edu
November 25, 2025 at 10:35 PM
“The number needed to harm for acute respiratory failure was 4,976 for the TMP-SMX versus amoxicillin cohort and 4,046 for the TMP-SMX versus cephalosporins cohort.” www.cidrap.umn.edu/antimicrobia...
“Kentucky had last recorded an infant whooping cough death in 2018.” www.cidrap.umn.edu/pertussis/th...
Third infant in Kentucky dies of whooping cough as national cases stay high for second year in a row
www.cidrap.umn.edu
November 25, 2025 at 10:34 PM
“Kentucky had last recorded an infant whooping cough death in 2018.” www.cidrap.umn.edu/pertussis/th...
“14% followed worsening or delayed-worsening trajectories, including a group whose symptoms remained minimal until spiking at month 15” www.cidrap.umn.edu/covid-19/stu...
Study maps 8 long-COVID symptom patterns in adults
www.cidrap.umn.edu
November 25, 2025 at 10:33 PM
“14% followed worsening or delayed-worsening trajectories, including a group whose symptoms remained minimal until spiking at month 15” www.cidrap.umn.edu/covid-19/stu...
“It is difficult to predict what will happen in the US & LA, as the severity of the flu season depends on multiple factors including circulating strains, pre-existing immunity, vaccine uptake, & the overall health of the population”
apple.news/AOYC-bFv9RU6...
apple.news/AOYC-bFv9RU6...
California braces for early, sharper flu season as virus mutation outpaces vaccine, experts say — Los Angeles Times
California could see an early and especially sharp start to the annual flu season, as a combination of low vaccination rates and late mutations to the virus may leave the state particularly exposed to...
apple.news
November 25, 2025 at 9:50 PM
“It is difficult to predict what will happen in the US & LA, as the severity of the flu season depends on multiple factors including circulating strains, pre-existing immunity, vaccine uptake, & the overall health of the population”
apple.news/AOYC-bFv9RU6...
apple.news/AOYC-bFv9RU6...
In this video I discuss leptospirosis
November 25, 2025 at 7:13 PM
In this video I discuss leptospirosis
“The state’s health department under his leadership was slow to react to the state’s worst whooping cough outbreak in three decades, waiting months to alert physicians and residents”
apple.news/AKaif9VqCRmu...
apple.news/AKaif9VqCRmu...
Louisiana health official who halted state vaccine campaign tapped as CDC’s No. 2 — The Washington Post
Ralph Abraham, a Louisiana health official who stopped promoting mass vaccination vaccines, has been appointed as the CDC's principal deputy director
apple.news
November 25, 2025 at 6:54 PM
“The state’s health department under his leadership was slow to react to the state’s worst whooping cough outbreak in three decades, waiting months to alert physicians and residents”
apple.news/AKaif9VqCRmu...
apple.news/AKaif9VqCRmu...
“During the Covid-19 pandemic, Dr. Ralph Lee Abraham promoted discredited treatments like ivermectin and, as Louisiana’s surgeon general, halted the state’s mass vaccination campaign” — he will fit in well with RFK and his band of nihilists www.nytimes.com/2025/11/25/h...
C.D.C. Quietly Appoints Doctor Critical of Vaccines as Second in Command
www.nytimes.com
November 25, 2025 at 6:49 PM
“During the Covid-19 pandemic, Dr. Ralph Lee Abraham promoted discredited treatments like ivermectin and, as Louisiana’s surgeon general, halted the state’s mass vaccination campaign” — he will fit in well with RFK and his band of nihilists www.nytimes.com/2025/11/25/h...
“In two independent trials using infusions of engineered antibodies, some participants remained healthy without taking antiretrovirals, long after the interventions ended.” knowablemagazine.org/content/arti...
Achieving lasting remission for HIV
People infected with HIV must take antiretroviral drugs for life. But promising trials using engineered antibodies suggest that ‘functional cures’ may be in reach.
knowablemagazine.org
November 25, 2025 at 5:29 PM
“In two independent trials using infusions of engineered antibodies, some participants remained healthy without taking antiretrovirals, long after the interventions ended.” knowablemagazine.org/content/arti...
“there have already been at least 650,000 illnesses, 7,400 hospitalizations, and 300 deaths from flu this season, ending the week of November 15.” www.newsweek.com/new-h3n2-flu...
New H3N2 flu strain hits the US: What to know
The emergence of the H3N2 variant has led experts to warn that this flu season could be particularly severe.
www.newsweek.com
November 25, 2025 at 4:21 PM
“there have already been at least 650,000 illnesses, 7,400 hospitalizations, and 300 deaths from flu this season, ending the week of November 15.” www.newsweek.com/new-h3n2-flu...
“Influenza A H3N2 is currently the most frequently reported flu strain in the U.S.—and viral testing shows a particularly concerning variant makes up the majority of cases.” www.scientificamerican.com/article/how-...
A New Flu Variant May Make Cold Season Brutal This Year
U.S. flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
www.scientificamerican.com
November 25, 2025 at 4:19 PM
“Influenza A H3N2 is currently the most frequently reported flu strain in the U.S.—and viral testing shows a particularly concerning variant makes up the majority of cases.” www.scientificamerican.com/article/how-...
In this piece I’m quoted about this season’s influenza strains. Despite the mismatch with one component, the vaccine will be valuable triblive.com/local/region...
New strain of flu invades Western Pa. amid concerns over vaccine efficacy
A new flu virus variant has been sweeping across the United States, raising questions about the efficacy of this year’s flu vaccines. Medical professionals in Western Pennsylvania say even thoug...
triblive.com
November 25, 2025 at 3:41 PM
In this piece I’m quoted about this season’s influenza strains. Despite the mismatch with one component, the vaccine will be valuable triblive.com/local/region...
“The new pricing arrangement was enabled by an advance payment through the International Finance Facility for Immunisation (IFFIm), which converts long-term donor pledges into upfront funds.” news.un.org/en/story/202...
Malaria vaccine price cut set to protect 7 million more children by 2030
Vaccine alliance Gavi and children’s agency UNICEF have struck a new pricing deal that will sharply cut the cost of a key malaria vaccine and make it possible to protect nearly seven million additiona...
news.un.org
November 25, 2025 at 3:37 PM
“The new pricing arrangement was enabled by an advance payment through the International Finance Facility for Immunisation (IFFIm), which converts long-term donor pledges into upfront funds.” news.un.org/en/story/202...
“Girls ages 16 years or younger who received HPV vaccines were 80% less likely than their unvaccinated counterparts to develop cervical cancer.” www.medpagetoday.com/hematologyon...
HPV Vaccination Tied to Huge Reduction in Cervical Cancer Risk
Two large meta-analyses reassure on safety, efficacy
www.medpagetoday.com
November 25, 2025 at 1:59 PM
“Girls ages 16 years or younger who received HPV vaccines were 80% less likely than their unvaccinated counterparts to develop cervical cancer.” www.medpagetoday.com/hematologyon...
“Regarding the stall in malaria morbidity and mortality, that single-dose therapy may contribute to saving more lives and provide implementation lessons that will be helpful when the next-generation drugs become available,” www.healio.com/news/infecti...
Study finds single-dose malaria treatment noninferior to standard of care
A single dose of a four-drug combination therapy for uncomplicated malaria was just as effective as the multi-day standard of care treatment, according to data presented at the American Society of Tro...
www.healio.com
November 25, 2025 at 1:56 PM
“Regarding the stall in malaria morbidity and mortality, that single-dose therapy may contribute to saving more lives and provide implementation lessons that will be helpful when the next-generation drugs become available,” www.healio.com/news/infecti...
“Taken together, the evidence from Latin America suggests that COVID-19 vaccination can reduce both the incidence and duration of PCC” www.idsociety.org/science-spea...
Post-COVID-19 conditions: Lessons from Latin America
The scarcity of studies in Latin America assessing vaccination as a preventive tool for long COVID highlights an important research gap.
www.idsociety.org
November 25, 2025 at 1:48 PM
“Taken together, the evidence from Latin America suggests that COVID-19 vaccination can reduce both the incidence and duration of PCC” www.idsociety.org/science-spea...
"In this nationwide study of more than 13 million persons in two countries there were no signs of an increased risk of myositis after SARS-CoV-2 vaccination, neither after the mRNA vaccines nor after the adenoviral vector vaccine," www.medpagetoday.com/infectiousdi...
Scandinavian Study Shreds COVID Vaccine-Myositis Link
No significant increase in risk with either mRNA or adenoviral vector vaccines
www.medpagetoday.com
November 25, 2025 at 1:46 PM
"In this nationwide study of more than 13 million persons in two countries there were no signs of an increased risk of myositis after SARS-CoV-2 vaccination, neither after the mRNA vaccines nor after the adenoviral vector vaccine," www.medpagetoday.com/infectiousdi...
“Estimated vaccine effectiveness was 29.3% against ED visits, 39.2% against hospitalizations, 64.0% against deaths, and 28.3% against a composite of all 3 outcomes” www.infectiousdiseaseadvisor.com/news/covid19...
COVID-19 Vaccines Effective Against Severe Outcomes in Veterans in 2024-2025 Season
The 2024 to 2025 COVID-19 vaccine reduced the risk for ED visits, hospitalizations, and deaths among US veterans.
www.infectiousdiseaseadvisor.com
November 25, 2025 at 1:46 PM
“Estimated vaccine effectiveness was 29.3% against ED visits, 39.2% against hospitalizations, 64.0% against deaths, and 28.3% against a composite of all 3 outcomes” www.infectiousdiseaseadvisor.com/news/covid19...
“Compared with the general US population, young adults aging with perinatally acquired HIV had mortality rates at least 5 times higher” www.infectiousdiseaseadvisor.com/news/mortali...
Mortality Risk Persists Into Adulthood in Perinatally Acquired HIV
Young adults aging with perinatally acquired HIV infection face high mortality rates, especially Black patients, when compared with the general US population.
www.infectiousdiseaseadvisor.com
November 25, 2025 at 1:44 PM
“Compared with the general US population, young adults aging with perinatally acquired HIV had mortality rates at least 5 times higher” www.infectiousdiseaseadvisor.com/news/mortali...
“Before the vaccine, there were an estimated 200,000 cases annually among children and up to 9,000 children died annually” abcnews.go.com/Health/25000...
More than 25,000 cases of whooping cough recorded this year, higher than pre-pandemic levels: CDC
More than 25,000 cases of whopping cough have been recorded in the U.S. so far this year, updated federal data shows.
abcnews.go.com
November 25, 2025 at 1:39 PM
“Before the vaccine, there were an estimated 200,000 cases annually among children and up to 9,000 children died annually” abcnews.go.com/Health/25000...
“There’s a fringe out there that thinks so, but they’re quite fringe.”— and you empowered them and gave them the reigns of political power. You stand with RFK not Jenner and Pasteur. www.politico.com/news/2025/11...
Vaccine-supporting Cassidy declines to speak against RFK Jr.
But Sen. Bill Cassidy, a physician, did emphasize his belief that vaccines are safe.
www.politico.com
November 25, 2025 at 12:24 PM
“There’s a fringe out there that thinks so, but they’re quite fringe.”— and you empowered them and gave them the reigns of political power. You stand with RFK not Jenner and Pasteur. www.politico.com/news/2025/11...
In this video I discuss antibiotic misuse and the threat of antibiotic resistance
November 24, 2025 at 10:57 PM
In this video I discuss antibiotic misuse and the threat of antibiotic resistance