The title seems higher than the paper.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
November 5, 2025 at 10:43 PM
The title seems higher than the paper.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
Slower focused search beats rushing. Taxi drivers who drive slower pick up more passengers. Attention > speed. Brilliant work!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
November 4, 2025 at 8:39 PM
Slower focused search beats rushing. Taxi drivers who drive slower pick up more passengers. Attention > speed. Brilliant work!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
If you refer to the analysis we did for you, half of the mutations were associated with the rRNA that is folded at the last step on both subunits. So the clustering is around assembly, not function. Probably leading to aberrant assembles, which would have implications when resources are limited.
November 3, 2025 at 11:29 AM
If you refer to the analysis we did for you, half of the mutations were associated with the rRNA that is folded at the last step on both subunits. So the clustering is around assembly, not function. Probably leading to aberrant assembles, which would have implications when resources are limited.
Science in the spotlight! Buildings in Shenzhen lit with research themes, and scientists Xue Qikun and Nieng Yan carrying the torch for the national games. So refreshing to see science celebrated. Congrats to both on the relay!
November 3, 2025 at 10:19 AM
Science in the spotlight! Buildings in Shenzhen lit with research themes, and scientists Xue Qikun and Nieng Yan carrying the torch for the national games. So refreshing to see science celebrated. Congrats to both on the relay!
Charting the landscape of cytoskeletal diversity in microbial eukaryotes: Cell www.cell.com/cell/fulltex...
Charting the landscape of cytoskeletal diversity in microbial eukaryotes
An imaging resource of over 200 microbial eukaryotic species provides a glimpse into
the remarkable universe of cytoskeletal diversity.
www.cell.com
October 31, 2025 at 5:45 PM
Charting the landscape of cytoskeletal diversity in microbial eukaryotes: Cell www.cell.com/cell/fulltex...
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Could you please post the rest of your sciart figs as well, for those who can't access the publication
October 30, 2025 at 12:52 PM
Could you please post the rest of your sciart figs as well, for those who can't access the publication
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
October 30, 2025 at 10:13 AM
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
Warm congratulations to the young scientists recipients of the 2025 Nordic Photosynthesis community prizes: Jannis Straube (Copenhagen), Vesa Havurinne (Aveiro), Laura Laihonen & Pablo Ortega Martínez (Turku @utu.fi)👏
Kudos to all participants🎉
See you in Umeå next time!
Kudos to all participants🎉
See you in Umeå next time!
October 25, 2025 at 7:08 AM
Warm congratulations to the young scientists recipients of the 2025 Nordic Photosynthesis community prizes: Jannis Straube (Copenhagen), Vesa Havurinne (Aveiro), Laura Laihonen & Pablo Ortega Martínez (Turku @utu.fi)👏
Kudos to all participants🎉
See you in Umeå next time!
Kudos to all participants🎉
See you in Umeå next time!
White beaked dolphins breach beside our boat in the North Atlantic as snowcapped peaks of Arctic fjords rise into clouds.
October 24, 2025 at 7:49 AM
White beaked dolphins breach beside our boat in the North Atlantic as snowcapped peaks of Arctic fjords rise into clouds.
Very sad. He was always so lively and encouraging when we met at college dinners. A great teacher for science and life. Deepest condolences.
October 8, 2025 at 10:03 AM
Very sad. He was always so lively and encouraging when we met at college dinners. A great teacher for science and life. Deepest condolences.
"You must take your opponent into a deep dark forest where 2+2 is not 4, and the path out is only wide enough for one.”
- Mikhail Tal
- Mikhail Tal
October 7, 2025 at 1:58 PM
"You must take your opponent into a deep dark forest where 2+2 is not 4, and the path out is only wide enough for one.”
- Mikhail Tal
- Mikhail Tal
The original publication describing the metrics: ‘Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps’ (2025) G. Pintilie, C. Shao, Z. Wang, B. Hudson, J. Flatt, M. Schmid, K. Morris, S. Burley, W. Chiu. Acta Cryst_D81:410-422
Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps
Q-scores are calculated for atomic models derived from 3D electron microscopy maps, measure how well the model fits the map and reflect the quality of the map itself. Here, we develop a statistical mo...
journals.iucr.org
October 1, 2025 at 12:25 AM
The original publication describing the metrics: ‘Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps’ (2025) G. Pintilie, C. Shao, Z. Wang, B. Hudson, J. Flatt, M. Schmid, K. Morris, S. Burley, W. Chiu. Acta Cryst_D81:410-422
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report
Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric
www.rcsb.org
October 1, 2025 at 12:25 AM
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
In Cambridge celebrating 25 years of ribosome structure studies. Wonderful to reconnect with friends, pioneers of the field, and engage with brilliant young scientists. Proud to be part of this community. Thank you @mrclmb.bsky.social for the amazing event! Great photos by Song, Nenad and Shaoxia
September 23, 2025 at 2:26 AM
In Cambridge celebrating 25 years of ribosome structure studies. Wonderful to reconnect with friends, pioneers of the field, and engage with brilliant young scientists. Proud to be part of this community. Thank you @mrclmb.bsky.social for the amazing event! Great photos by Song, Nenad and Shaoxia
1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer
September 9, 2025 at 11:42 PM
1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer
He is calling it his ‘last’ ribosome talk… but who believes that
September 7, 2025 at 8:03 PM
He is calling it his ‘last’ ribosome talk… but who believes that
A dramatic blood moon is lighting up the sky above Churchill College as Venki @mrclmb.bsky.social delivers the plenary on ribosome synthesis, a memorable alignment of breakthrough in structural biology and the cosmos tonight.
September 7, 2025 at 7:53 PM
A dramatic blood moon is lighting up the sky above Churchill College as Venki @mrclmb.bsky.social delivers the plenary on ribosome synthesis, a memorable alignment of breakthrough in structural biology and the cosmos tonight.
Speak up before more is lost. UCLA lost $600M in federal research grants, freezing work on cancer, neurodegeneration, pediatrics & more. Entire labs, careers, and patients remain in limbo. A devastating blow to US science. Trainees are hardest hit, the community must speak up before more is lost.
Frozen Grants, Canceled Futures: The Human Toll of UCLA’s Research Suspension
A frozen grant is more than halted experiments and lost data; it is a career derailed for many of the trainees dependent on this research support.
www.the-scientist.com
September 5, 2025 at 12:05 AM
Speak up before more is lost. UCLA lost $600M in federal research grants, freezing work on cancer, neurodegeneration, pediatrics & more. Entire labs, careers, and patients remain in limbo. A devastating blow to US science. Trainees are hardest hit, the community must speak up before more is lost.
The paper is a masterpiece of modern evolutionary genomics with a potential for synthetic biology. Imagine designing new genes from scratch to improve plant traits.
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
A de novo-originated gene drives rose scent diversification
Genomic analysis of more than 100 Rosa species uncovers a multi-step process for the
de novo origination of SCREP, a taxon-restricted gene specific to the Rosa genus,
highlighting its function in modu...
www.cell.com
September 3, 2025 at 1:40 AM
The paper is a masterpiece of modern evolutionary genomics with a potential for synthetic biology. Imagine designing new genes from scratch to improve plant traits.
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...