Richard Lee
@antibioticchem.bsky.social
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.
www.nature.com
November 13, 2025 at 9:44 PM
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Richard Lee
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
bit.ly/Dabas_Pol2
Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
bit.ly
November 7, 2025 at 3:45 PM
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
bit.ly/Dabas_Pol2
Reposted by Richard Lee
Excellent research out of the Lee Lab by
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery
Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
bit.ly
November 10, 2025 at 6:43 PM
Excellent research out of the Lee Lab by
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery
Our new paper in ACS Infectious Diseases describes the development of a Gram-negative drug discovery platform to optimize drugs that engage their targets within the cytoplasm.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
pubs.acs.org
October 26, 2025 at 9:01 PM
Our new paper in ACS Infectious Diseases describes the development of a Gram-negative drug discovery platform to optimize drugs that engage their targets within the cytoplasm.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Richard Lee
Now that the policy is out, we've rolled out an updated version of the story.
bsky.app/profile/maxk...
bsky.app/profile/maxk...
NIH is ending billions of dollars in foreign subawards, jeopardizing thousands of projects on infectious diseases, cancer and more.
Unless foreign researchers secure funding directly from NIH by October — a tall order for any researcher — clinical trials abroad and other research will shut down.
Unless foreign researchers secure funding directly from NIH by October — a tall order for any researcher — clinical trials abroad and other research will shut down.
Exclusive: NIH to end billions of dollars in foreign research grants
Move by US biomedical agency jeopardizes thousands of projects on infectious diseases, cancer and more.
www.nature.com
May 2, 2025 at 1:05 AM
Now that the policy is out, we've rolled out an updated version of the story.
bsky.app/profile/maxk...
bsky.app/profile/maxk...
Reposted by Richard Lee
GLP-1 agonists continue to be one of the most high-profile pharmaceutical battlegrounds. A look at recent developments:
The GLP-1 Saga Continues, And How
www.science.org
May 1, 2025 at 7:13 PM
GLP-1 agonists continue to be one of the most high-profile pharmaceutical battlegrounds. A look at recent developments:
Reposted by Richard Lee
Reposted by Richard Lee
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
cen.acs.org
March 28, 2025 at 4:53 PM
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
Reposted by Richard Lee
Updated Dashboard
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35)
This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See bsky.app/profile/jere...
1/3
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35)
This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See bsky.app/profile/jere...
1/3
March 26, 2025 at 10:57 PM
Updated Dashboard
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35)
This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See bsky.app/profile/jere...
1/3
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35)
This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See bsky.app/profile/jere...
1/3
Reposted by Richard Lee
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
CBT rising stars in chemical biology is today, many outstanding talks from junior scientists
January 17, 2025 at 5:27 PM
CBT rising stars in chemical biology is today, many outstanding talks from junior scientists