Aaron Ragsdale
apragsdale.bsky.social
Aaron Ragsdale
@apragsdale.bsky.social
Reposted by Aaron Ragsdale
Howell et al. used WGS of wild-caught deer mice from two islands and one mainland location in British Columbia to investigate chromosomal inversions and non-equilibrium demographic history of this species.

🔗 doi.org/10.1093/molbev/msaf254

#evobio #molbio #peromyscus
The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice
Abstract. Populations that colonize islands experience novel selective pressures, fluctuations in size, and changes to their connectivity. Owing to their u
doi.org
November 21, 2025 at 12:19 PM
In an earlier project simulating quantitative traits/stabilizing selection in a human-Neanderthal model, I became a bit curious about some observed fitness dynamics that I wasn’t expecting.

I’m not sure if this is all that interesting or relevant, but at least it’s short.
Mean fitness is maximized in small populations under stabilizing selection on highly polygenic traits https://www.biorxiv.org/content/10.1101/2025.11.17.688329v1
November 21, 2025 at 11:09 AM
Wisconsin Evolution is accepting applications for our Seminar Series' Early Career Scientist Award. Come share your evolution research and visit UW-Madison's evolution community. Open to grad students and postdocs (<5 yrs post PhD) from outside UW-Madison.

Apply by Dec 15th here: shorturl.at/4a4O6
Early Career Scientist Awards 2026
Application to the UW-Madison Evolution Seminar Series - Early Career Scientist Awards.
urldefense.com
November 19, 2025 at 8:55 PM
Reposted by Aaron Ragsdale
Elevated mutation near crossovers inhibits the evolution of recombination https://www.biorxiv.org/content/10.1101/2025.11.01.685904v1
November 2, 2025 at 3:32 AM
Reposted by Aaron Ragsdale
A model for background selection in non-equilibrium populations https://www.biorxiv.org/content/10.1101/2025.02.19.639084v1
February 21, 2025 at 11:39 AM
Reposted by Aaron Ragsdale
The deadline for the Early Career Award applications has been extended to Dec. 7th! There is still time to apply 🧬🐝🐠🍄

If you are a graduate student or a postdoc interested in #evolution, apply today!
We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30.

evolution.wisc.edu/seminars/ear...

Please share with grad students and postdocs working in evolutionary biology!
Early Career Award Seminar
The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...
evolution.wisc.edu
December 3, 2024 at 5:03 PM
Reposted by Aaron Ragsdale
We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30.

evolution.wisc.edu/seminars/ear...

Please share with grad students and postdocs working in evolutionary biology!
Early Career Award Seminar
The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...
evolution.wisc.edu
November 14, 2024 at 6:22 PM
Anyone know if archaic hominin sequences (Vindija, Altai Neanderthals, Denisova) have been re-called in reference build 38 and publicly available somewhere?
November 25, 2024 at 6:34 PM
Our paper on allele frequency transitions under polygenic selection, with a focus on evolve & resequence experiments, is up at Genetics. Led by grad student Nathan Anderson:

urldefense.com/v3/__https:/...
A path integral approach for allele frequency dynamics under polygenic selection
Abstract. Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotyp
urldefense.com
November 20, 2024 at 2:05 PM
We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30.

evolution.wisc.edu/seminars/ear...

Please share with grad students and postdocs working in evolutionary biology!
Early Career Award Seminar
The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...
evolution.wisc.edu
November 14, 2024 at 6:22 PM
I wrote a review of the recent paper from Harris, Platt, Tishkoff et al. on early human-to-Neanderthal introgression, out as a Dispatch in Current Biology.

Quick read, free link: authors.elsevier.com/a/1i7L53QW8S...
November 20, 2023 at 7:04 PM
This is a really interesting paper: www.cell.com/current-biol...

Early human introgression into Neanderthals around 250 thousand years ago, resulting in up to 6% human DNA in Neanderthals. And then evidence that human-introgressed alleles were selected against after their introduction.
October 13, 2023 at 10:09 PM
What I thought was an easy algebra problem, that is giving me a headache: I am looking for a way to generate all subsets of the power set for a given K that are closed under union of disjoint sets and complementation of nested sets.
October 3, 2023 at 12:16 AM