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Arwen Gao

@arwengao.bsky.social

48 followers 130 following 6 posts

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Arwen Gao @arwengao.bsky.social · Jun 26

Thrilled to share our new study:

“A lysosomal surveillance response to stress extends healthspan”

Knockdown of vha-6 in C. elegans activates LySR—a protective program that boosts lysosomal activity, clears aggregates, and extends lifespan.

www.nature.com/articles/s41...

#lysosomes #LySR #aging

A lysosomal surveillance response to stress extends healthspan - Nature Cell Biology

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance...

www.nature.com

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Arwen Gao @arwengao.bsky.social · Sep 8

Aging cells struggle to recycle waste. Lysosomes are the cell’s recycling hubs. When they fade, damage builds up. We asked: can lipid metabolism (via PLAG-15) “wake up” lysosome genes and improve cellular housekeeping?

Arwen Gao @arwengao.bsky.social · Sep 8

Check out our newly published paper at IScience! We showed that knocking down a fat-processing enzyme gene, plag-15, can switch on lysosome programs and extend lifespan in worms! cell.com/iscience/ful...
#Healthyaging #lysosome #Celegans

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Molecular physiology; Lipidomics; Transcriptomics

cell.com

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Arwen Gao @arwengao.bsky.social · Aug 19

Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting!
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands

Annual meeting 2025

Welcome message from the organizing committee In 2025, the Dutch Society for Aging Research (DuSRA) is proud to host its Annual Scientific Meeting on 10–11 November 2025 in Amsterdam. Over two days, ...

dusra.nl

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Reposted by Arwen Gao

auwerx-lab.bsky.social @auwerx-lab.bsky.social · Jul 3

Congrats to the Terytty, @arwengao.bsky.social and colleagues for identifying the importance of Lysosomal Surveillance Response (LysR) in fighting age-related protein accumulation. news.epfl.ch/news/a-recyc...
www.nature.com/articles/s41...

A recycling mechanism that helps cells fight aging

An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell’s lysosomes can help clear waste and promote healthy aging. The findings o...

news.epfl.ch

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Arwen Gao @arwengao.bsky.social · Jun 26

A lysosomal surveillance response to stress extends healthspan - Nature Cell Biology

www.nature.com

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Reposted by Arwen Gao

Riekelt Houtkooper @rhhoutkooper.bsky.social · Dec 3

Save the date! DTMC 2025 is promising to be super exciting! Watch this space for updates, or sign up for the newsletter!

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Arwen Gao @arwengao.bsky.social · May 28

Team members from our group are presenting at #DTMC2025😊😊