Groundbreaking new tests reveal patterns in our immune systems that can signal underlying disease and tell us how well we might recover from our next cold. I got my results in a text message.

Signal Transduction and Targeted Therapy - Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-containing vaccine booster

The newfound ensemble of neurons could lead to therapies to treat persistent pain, which affects roughly one of five people globally.

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL-5 and IL-10.

This double-controlled study, incorporating pre- versus post-infection and uninfected symptom data, found a low risk of PCC among a community-dwelling adult population infected during the autumn 2023 ...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused significant global morbidity since 2019. Long-COVID, characterized by persistent symptoms after acute infection, may involve end...

Background Covid-19 is a pandemic acute infectious disease that emerged in 2019. It is estimated that 10–20% will develop persistent symptoms, known as long Covid or post-Covid syndrome. The risk factors for the development of this syndrome are still being studied. Psychosocial factors are known to increase the duration and severity of respiratory infections. Aims (i) to review current knowledge of the link between past psychiatric history and the development of long Covid; (ii) to obtain information on the psychological experience of the initial infection; (iii) to establish a link between the presence of psychiatric symptoms during the acute phase and the development of long Covid. Method We conducted a systematic review according to PRISMA standards using the Pubmed, Science Direct and Scopus databases. We included observational studies of adult subjects with long Covid whose psychiatric and/or addictive histories were searched. Results A total of 36 articles were included in our review. Depression and anxiety appear to be risk factors for the development of long Covid. There is no consensus on the contribution of smoking to the onset of the syndrome. The negative psychological experience of the acute infection favours the persistence of symptoms. Psychological symptoms during the acute phase, studied in only one of our articles, seem to contribute to the persistence of concentration and attention problems. Conclusion Psychological comorbidities pre-existing COVID-19 infection, in particular depression and anxiety, as well as a poor psychological experience of the acute phase, may favour the development of long Covid. Trial registration number PROSPERO registration number CRD42023391720.

Scientific Reports - Gross hematuria after COVID-19 mRNA vaccination and kidney function trajectory in IgA nephropathy

During the global COVID-19 pandemic, mRNA vaccines using the S protein as antigen were widely used.Vaccine-induced S proteins can persist in vivo for weeks, triggering low-level immune activation. HIV...

COVID-19 has increasingly been linked to neurological complications that may overlap with those observed in neurodegenerative and autoimmune diseases. In this study, we analyzed single-cell RNA-sequen...

Post-acute sequelae of COVID-19 (Long COVID) includes physical and cognitive symptoms that can last long after acute infection. Links between lung pathophysiology and cognitive dysfunction in Long COV...

Long COVID can upend the lives of those who have it—when you’re a student, it can be even harder

Scientific Reports - Analytical and machine learning approaches identify a sea star steroid with promising activity for COVID-19 therapeutic development

Cell Death & Disease - SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability

npj Digital Medicine - Systematic review: digital biomarkers of fatigue in chronic diseases

People living in rural areas of the United States have poorer outcomes from acute COVID-19. Here, the authors show that higher mortality rates among rural dwellers persist for up to two years after the initial infection, even after accounting for baseline risk factors.

Polymerase template switching is an essential mechanism in coronaviruses (CoVs) that enables both sub-genomic (sg) RNA synthesis and increases genomic diversity via RNA recombination. Despite its impo...

Ensitrelvir is an antiviral drug that specifically targets the main protease (Mpro) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been approved for the treatment of coronavirus d...

Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets driving checkpoint inhibition-elicited pro-atherosclerotic immune responses. They further demonstrate elevated levels of circulating PD-1-expressing T cells in individuals with subclinical cardiovascular disease.

Scientific Reports - COVID-19 vaccination lowers SARS-CoV-2 infection risk independent of diabetes, cancer and smoking in SHIP-COVID cohort, Northern Germany

BackgroundAlthough COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesiz...