A. Berçin Barlas
@aysebercinb.bsky.social
Postdoctoral Researcher @Izmir Biomedicine and Genome Center - Computational Structural Biology Lab.
Reposted by A. Berçin Barlas
🚀 Excited to announce that our perspective piece with @ezgikaraca.bsky.social and @aysebercinb.bsky.social on AlphaFold distograms is now published in @febsletters.bsky.social!!
Here is what we did further 👇
Here is what we did further 👇
🚨 Super excited for our new preprint on flexibility cues in AlphaFold!
Together with @ezgikaraca.bsky.social and @aysebercinb.bsky.social, we found that distograms of AF2.3 and AF3 mirror MD sampling by predicting the extent of a novel conformational change! 🤯
For more👇
Together with @ezgikaraca.bsky.social and @aysebercinb.bsky.social, we found that distograms of AF2.3 and AF3 mirror MD sampling by predicting the extent of a novel conformational change! 🤯
For more👇
Exploring the Potential of AlphaFold Distograms for Flexibility Assignment in Cryo-EM Maps https://www.biorxiv.org/content/10.1101/2025.07.25.666757v1
February 9, 2026 at 2:40 PM
🚀 Excited to announce that our perspective piece with @ezgikaraca.bsky.social and @aysebercinb.bsky.social on AlphaFold distograms is now published in @febsletters.bsky.social!!
Here is what we did further 👇
Here is what we did further 👇
Reposted by A. Berçin Barlas
364 days a year we use AlphaFold to predict protein structure…
But not on Christmas Eve! That’s when Santa does the predictions. But beware, computational structural biologists on the naughty list will only get low pLDDTs #SantaFold #bananapro
But not on Christmas Eve! That’s when Santa does the predictions. But beware, computational structural biologists on the naughty list will only get low pLDDTs #SantaFold #bananapro
December 11, 2025 at 2:52 PM
364 days a year we use AlphaFold to predict protein structure…
But not on Christmas Eve! That’s when Santa does the predictions. But beware, computational structural biologists on the naughty list will only get low pLDDTs #SantaFold #bananapro
But not on Christmas Eve! That’s when Santa does the predictions. But beware, computational structural biologists on the naughty list will only get low pLDDTs #SantaFold #bananapro
Reposted by A. Berçin Barlas
And the legacy continues! 😊
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
October 6, 2025 at 1:13 PM
And the legacy continues! 😊
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
🚀 Excited to share that our article with @ezgikaraca.bsky.social is now published in Communications Biology!
In this study, we explored DNA readout rules of almost identical DNMT3A and DNMT3B (91% sequence similarity!), and we asked: how can nearly the same proteins “see” DNA so differently? 🧬✨
In this study, we explored DNA readout rules of almost identical DNMT3A and DNMT3B (91% sequence similarity!), and we asked: how can nearly the same proteins “see” DNA so differently? 🧬✨
Comparative dynamics analysis identifies key residues driving sequence specificity differences between human DNA methyltransferases DNMT3A and DNMT3B.
@aysebercinb.bsky.social
@ezgikaraca.bsky.social
www.nature.com/articles/s42...
@aysebercinb.bsky.social
@ezgikaraca.bsky.social
www.nature.com/articles/s42...
So close yet so far apart: distinct flanking sequence recognition by DNMT3A and DNMT3B - Communications Biology
Comparative dynamics analysis identifies key residues driving sequence specificity differences between human DNA methyltransferases DNMT3A and DNMT3B.
www.nature.com
August 22, 2025 at 10:48 AM
🚀 Excited to share that our article with @ezgikaraca.bsky.social is now published in Communications Biology!
In this study, we explored DNA readout rules of almost identical DNMT3A and DNMT3B (91% sequence similarity!), and we asked: how can nearly the same proteins “see” DNA so differently? 🧬✨
In this study, we explored DNA readout rules of almost identical DNMT3A and DNMT3B (91% sequence similarity!), and we asked: how can nearly the same proteins “see” DNA so differently? 🧬✨