The Batlle Lab
@batllelab.bsky.social
We work on minimal residual disease and metastasis by colorectal cancer from the perspective of cancer stem cells and their interaction with the tumor microenvironment.
@IRBBarcelona,bsky.social
@IRBBarcelona,bsky.social
Reposted by The Batlle Lab
PODCAST: Conversaciones del Premio Nobel
Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
November 25, 2025 at 9:55 AM
PODCAST: Conversaciones del Premio Nobel
Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
Producida por Nobel Prize Outreach y la @fundacionareces.bsky.social, los podcast de la serie "Conversaciones del Premio Nobel " proponen acercar a la sociedad española los logros de estos científicos y sus historias personales.
Reposted by The Batlle Lab
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 7, 2025 at 12:30 PM
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
Reposted by The Batlle Lab
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 27, 2025 at 2:39 PM
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
Reposted by The Batlle Lab
⏳Countdown to the 14th #CNAGSymposium!
🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer”
🗓️Dec 16, BCN
📎 www.cnag.eu/events/14th-...
@batllelab.bsky.social
🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer”
🗓️Dec 16, BCN
📎 www.cnag.eu/events/14th-...
@batllelab.bsky.social
November 17, 2025 at 10:47 AM
⏳Countdown to the 14th #CNAGSymposium!
🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer”
🗓️Dec 16, BCN
📎 www.cnag.eu/events/14th-...
@batllelab.bsky.social
🗣️Don’t miss Dr. Eduard Batlle from @irbbarcelona.org (@icreacommunity.bsky.social), sharing his insights on “Plasticity, therapy resistance, and immune evasion in metastatic colorectal cancer”
🗓️Dec 16, BCN
📎 www.cnag.eu/events/14th-...
@batllelab.bsky.social
Reposted by The Batlle Lab
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Reposted by The Batlle Lab
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
🧪
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
🧪
November 7, 2025 at 10:01 AM
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
🧪
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
🧪
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 7, 2025 at 12:30 PM
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
Reposted by The Batlle Lab
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr
#tumorbiology
#tumorbiology
November 5, 2025 at 12:12 PM
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr
#tumorbiology
#tumorbiology
At the Oncode Annual Conference 2025. Fantastic Meeting. Thanks for the invite. Catching up with many colleagues and friends.
www.oncodeinstitute.nl/events/oncod...
www.oncodeinstitute.nl/events/oncod...
Oncode Annual Conference 2025 | Oncode Institute
Registration is closed!There are roadworks, so the public transport route is different from previous years. For up-to-date information, please use Reisplanner | GVB or Plan je reis met het OV en deelv...
www.oncodeinstitute.nl
November 6, 2025 at 6:38 PM
At the Oncode Annual Conference 2025. Fantastic Meeting. Thanks for the invite. Catching up with many colleagues and friends.
www.oncodeinstitute.nl/events/oncod...
www.oncodeinstitute.nl/events/oncod...
Reposted by The Batlle Lab
Registration for Cancer Cell Plasticity closes on Monday 03 November!
Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels:
eacr.org/conference/c...
Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels:
eacr.org/conference/c...
October 29, 2025 at 9:03 AM
Registration for Cancer Cell Plasticity closes on Monday 03 November!
Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels:
eacr.org/conference/c...
Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels:
eacr.org/conference/c...
🙌🏼 What a fantastic meeting this was! Congrats to everyone who contributed! #EESOrgan @events.embo.org
🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference.
📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference.
📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
October 29, 2025 at 10:24 AM
🙌🏼 What a fantastic meeting this was! Congrats to everyone who contributed! #EESOrgan @events.embo.org
🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference.
📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
🔝 A huge thank you to the organizers for the invitation, and for putting together such a memorable conference.
📸 A remarkable aspect was seeing together five generations of Clevers’ Lab!!
📣 Last chance to register for the EACR virtual conference on Cancer Cell Plasticity
You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them
➡️https://eacr.org/conference/cancercellplasticity2025
@helloeacr.bsky.social
You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them
➡️https://eacr.org/conference/cancercellplasticity2025
@helloeacr.bsky.social
October 29, 2025 at 8:43 AM
📣 Last chance to register for the EACR virtual conference on Cancer Cell Plasticity
You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them
➡️https://eacr.org/conference/cancercellplasticity2025
@helloeacr.bsky.social
You’ll gain new insights into fundamental mechanisms controlling cancer cell plasticity as well as innovative approaches to target them
➡️https://eacr.org/conference/cancercellplasticity2025
@helloeacr.bsky.social
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 27, 2025 at 2:39 PM
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
Reposted by The Batlle Lab
➡️ This important video was missing from yesterday’s #Bluetorial.
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
October 24, 2025 at 6:47 AM
➡️ This important video was missing from yesterday’s #Bluetorial.
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
➡️ This important video was missing from yesterday’s #Bluetorial.
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
October 24, 2025 at 6:47 AM
➡️ This important video was missing from yesterday’s #Bluetorial.
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.
Centonze et al., in #CancerDiscovery
#AACR
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Lab Celebrations are in order. More news to come
October 17, 2025 at 7:22 AM
Lab Celebrations are in order. More news to come
Reposted by The Batlle Lab
🏆 El lliurament dels Premis Dia del Biòleg 2025 de @biolegscat.bsky.social tindrà lloc demà 25 d'abril a les 16:30 h al COACB.
Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona!
🔴 Segueix la cerimònia en directe aquí: https://f.mtr.cool/egtmfleqvu
Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona!
🔴 Segueix la cerimònia en directe aquí: https://f.mtr.cool/egtmfleqvu
April 24, 2025 at 10:01 AM
🏆 El lliurament dels Premis Dia del Biòleg 2025 de @biolegscat.bsky.social tindrà lloc demà 25 d'abril a les 16:30 h al COACB.
Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona!
🔴 Segueix la cerimònia en directe aquí: https://f.mtr.cool/egtmfleqvu
Enhorabona a tots els guardonats! Entre ells, @batllelab.bsky.social, de l'#IRBBarcelona!
🔴 Segueix la cerimònia en directe aquí: https://f.mtr.cool/egtmfleqvu
Estic molt agraït pel reconeixement rebut. Em sap greu no haver pogut assistir a l’acte de lliurament del premi i a la celebració del Dia del Biòleg. Afortunadament, l’equip hi ha pogut ser present en representació.
April 25, 2025 at 4:16 PM
Estic molt agraït pel reconeixement rebut. Em sap greu no haver pogut assistir a l’acte de lliurament del premi i a la celebració del Dia del Biòleg. Afortunadament, l’equip hi ha pogut ser present en representació.
Un placer y un honor dar la 28a Lección Conmemorativa Teófilo Hernando. Amigos, colaboradores y científicos a los que respeto y admiro entre los ponentes anteriores.
April 25, 2025 at 9:41 AM
Un placer y un honor dar la 28a Lección Conmemorativa Teófilo Hernando. Amigos, colaboradores y científicos a los que respeto y admiro entre los ponentes anteriores.
It’s a pleasure to present our work at CRG’s annual symposium. Many good friends and colleagues around.
April 24, 2025 at 2:15 PM
It’s a pleasure to present our work at CRG’s annual symposium. Many good friends and colleagues around.
Reposted by The Batlle Lab
🗣️«Estamos empezando a entender cómo se genera la #metástasis y a ser capaces de prevenirlas y eliminarlas cuando ya se han producido».
🗨️ @batllelab.bsky.social
#DebatesCaixaResearch
🗨️ @batllelab.bsky.social
#DebatesCaixaResearch
February 20, 2025 at 7:31 AM
🗣️«Estamos empezando a entender cómo se genera la #metástasis y a ser capaces de prevenirlas y eliminarlas cuando ya se han producido».
🗨️ @batllelab.bsky.social
#DebatesCaixaResearch
🗨️ @batllelab.bsky.social
#DebatesCaixaResearch
En Sevilla, en las Jornadas conjuntas CIBERONC CIBER_OBN. @ciberisciii.bsky.social
February 14, 2025 at 8:13 AM
En Sevilla, en las Jornadas conjuntas CIBERONC CIBER_OBN. @ciberisciii.bsky.social
Reposted by The Batlle Lab
🗣️Debate #CaixaResearch: “La incidencia de #CáncerdeColon aumenta entre los jóvenes"
Con @batllelab.bsky.social y @tonigabaldon.bsky.social (@irbbarcelona.org), Angélica Figueroa (INIBIC) y Elena Élez (@vhio.bsky.social).
🗓️ Miércoles 19 febrero
🕖 19 h
💻 online
➡️ https://tinyurl.com/bdda8tsr
🧪
Con @batllelab.bsky.social y @tonigabaldon.bsky.social (@irbbarcelona.org), Angélica Figueroa (INIBIC) y Elena Élez (@vhio.bsky.social).
🗓️ Miércoles 19 febrero
🕖 19 h
💻 online
➡️ https://tinyurl.com/bdda8tsr
🧪
February 12, 2025 at 10:01 AM
🗣️Debate #CaixaResearch: “La incidencia de #CáncerdeColon aumenta entre los jóvenes"
Con @batllelab.bsky.social y @tonigabaldon.bsky.social (@irbbarcelona.org), Angélica Figueroa (INIBIC) y Elena Élez (@vhio.bsky.social).
🗓️ Miércoles 19 febrero
🕖 19 h
💻 online
➡️ https://tinyurl.com/bdda8tsr
🧪
Con @batllelab.bsky.social y @tonigabaldon.bsky.social (@irbbarcelona.org), Angélica Figueroa (INIBIC) y Elena Élez (@vhio.bsky.social).
🗓️ Miércoles 19 febrero
🕖 19 h
💻 online
➡️ https://tinyurl.com/bdda8tsr
🧪