Biophysical Journal
@biophysj.bsky.social
The premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research. Editor-in-Chief: Vasanthi Jayaraman.
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/paintin...
Painting the Birth of an Artificial Cell
The cover image was inspired by my long-standing hobby of watercolor painting. When traveling, I often carry a small sketchbook and watercolor inks to capture buildings, streets, and landscapes. For t...
www.biophysics.org
February 3, 2026 at 3:40 PM
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/paintin...
#OPENACCESS: Multiscale simulations of folded and intrinsically disordered region-containing protein condensates. Lyudmyla Dorosh, Holger Wille, and Maria Stepanova.
www.cell.com
January 30, 2026 at 3:04 PM
#OPENACCESS: Multiscale simulations of folded and intrinsically disordered region-containing protein condensates. Lyudmyla Dorosh, Holger Wille, and Maria Stepanova.
#OPENACCESS: Coarse-grained Martini 3 model for collagen fibrils. Matthias Brosz, Johanna Buck, Fabian Grünewald, Debora Monego, Jaewoon Jung, Yuji Sugita, Camilo Aponte-Santamaría, and Frauke Gräter.
www.cell.com
January 29, 2026 at 7:01 PM
#OPENACCESS: Coarse-grained Martini 3 model for collagen fibrils. Matthias Brosz, Johanna Buck, Fabian Grünewald, Debora Monego, Jaewoon Jung, Yuji Sugita, Camilo Aponte-Santamaría, and Frauke Gräter.
#OPENACCESS: Structural basis for efficient Fo motor rotation revealed by MCMD simulation and structural analysis. Shintaroh Kubo and Hiroyuki Noji.
www.cell.com
January 29, 2026 at 3:03 PM
#OPENACCESS: Structural basis for efficient Fo motor rotation revealed by MCMD simulation and structural analysis. Shintaroh Kubo and Hiroyuki Noji.
Capturing the dance of the exit tunnel of the ribosome using course-grain simulations illustrates the ballet of newly formed polypeptide.
www.cell.com
January 28, 2026 at 3:03 PM
Capturing the dance of the exit tunnel of the ribosome using course-grain simulations illustrates the ballet of newly formed polypeptide.
Special issue call for papers: Viral Biophysics.
buff.ly
January 27, 2026 at 8:30 PM
Special issue call for papers: Viral Biophysics.
#OPENACCESS: Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations. Timothy S. Carpenter and Fikret Aydin, et al.
www.cell.com
January 27, 2026 at 7:03 PM
#OPENACCESS: Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations. Timothy S. Carpenter and Fikret Aydin, et al.
A meta-analysis dissects the effect of protein primary-sequence variations on the conformational ensembles populated by protein kinases.
www.cell.com
January 27, 2026 at 3:04 PM
A meta-analysis dissects the effect of protein primary-sequence variations on the conformational ensembles populated by protein kinases.
#OPENACCESS: On the curvature and relaxation of microtubule plus-end tips.
Tomasz Skóra, Jiangbo Wu, Daniel Beckett, Weizhi Xue, Gregory A. Voth, and Tamara C. Bidone.
Tomasz Skóra, Jiangbo Wu, Daniel Beckett, Weizhi Xue, Gregory A. Voth, and Tamara C. Bidone.
www.cell.com
January 26, 2026 at 7:02 PM
#OPENACCESS: On the curvature and relaxation of microtubule plus-end tips.
Tomasz Skóra, Jiangbo Wu, Daniel Beckett, Weizhi Xue, Gregory A. Voth, and Tamara C. Bidone.
Tomasz Skóra, Jiangbo Wu, Daniel Beckett, Weizhi Xue, Gregory A. Voth, and Tamara C. Bidone.
New study using coarse-grained simulations shows how amphiphilic polypeptide-based polymers self-assemble and disassemble in response to binding of a specific protein, paving the way for responsive drug delivery systems and biosensors.
www.cell.com
January 26, 2026 at 3:03 PM
New study using coarse-grained simulations shows how amphiphilic polypeptide-based polymers self-assemble and disassemble in response to binding of a specific protein, paving the way for responsive drug delivery systems and biosensors.
#OPENACCESS: Using coarse-grained molecular dynamics simulations, Brown et al. compare three computational techniques to calculate lipid bilayer bending modulus, revealing method-dependent variations and the complexity of quantifying membrane mechanics.
www.cell.com
January 23, 2026 at 3:02 PM
#OPENACCESS: Using coarse-grained molecular dynamics simulations, Brown et al. compare three computational techniques to calculate lipid bilayer bending modulus, revealing method-dependent variations and the complexity of quantifying membrane mechanics.
#OPENACCESS: Asymmetry and heterogeneity in the plasma membrane. Teppei Yamada and Wataru Shinoda.
www.cell.com
January 22, 2026 at 7:01 PM
#OPENACCESS: Asymmetry and heterogeneity in the plasma membrane. Teppei Yamada and Wataru Shinoda.
Artificial intelligence and machine learning are talks of the town today and are making strides in all aspects of science. This review highlights recent advances in machine-learning-driven biomolecular simulations to enhance accuracy and extend the simulation timescales.
Link:
Link:
www.cell.com
January 22, 2026 at 3:02 PM
Artificial intelligence and machine learning are talks of the town today and are making strides in all aspects of science. This review highlights recent advances in machine-learning-driven biomolecular simulations to enhance accuracy and extend the simulation timescales.
Link:
Link:
#OPENACCESS: Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell. Rajneesh Kumar and Iain G. Johnston.
www.cell.com
January 21, 2026 at 8:30 PM
#OPENACCESS: Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell. Rajneesh Kumar and Iain G. Johnston.
Sharma and colleagues combine all-atom and coarse-grained molecular dynamics simulations with protein design and machine learning to uncover how sotrovimab resistance emerges in SARS-CoV-2, revealing key resistance mutations.
www.cell.com
January 21, 2026 at 5:00 PM
Sharma and colleagues combine all-atom and coarse-grained molecular dynamics simulations with protein design and machine learning to uncover how sotrovimab resistance emerges in SARS-CoV-2, revealing key resistance mutations.
Check out the newly-released issue of Biophysical Journal: www.cell.com/biophysj/cur...
Issue: Biophysical Journal
www.cell.com
January 21, 2026 at 12:55 PM
Check out the newly-released issue of Biophysical Journal: www.cell.com/biophysj/cur...
#OPENACCESS: How protein hydration depends on amino acid composition, peptide conformation, and force fields. Johanna-Barbara Linse, Tobias M. Fischbach, and Jochen S. Hub.
www.cell.com
January 16, 2026 at 9:45 PM
#OPENACCESS: How protein hydration depends on amino acid composition, peptide conformation, and force fields. Johanna-Barbara Linse, Tobias M. Fischbach, and Jochen S. Hub.
#OPENACCESS: Dynamics of excitability in axonal trees. Laurie D. Cohen, Tamar Galateanu, and Shimon Marom.
www.cell.com
January 16, 2026 at 7:30 PM
#OPENACCESS: Dynamics of excitability in axonal trees. Laurie D. Cohen, Tamar Galateanu, and Shimon Marom.
#OPENACCESS: The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction. Ruichen Sui, Nicolae Moise, and Seth H. Weinberg.
www.cell.com
January 16, 2026 at 5:05 PM
#OPENACCESS: The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction. Ruichen Sui, Nicolae Moise, and Seth H. Weinberg.
Special issue call for papers: Viral Biophysics.
buff.ly
January 16, 2026 at 2:31 PM
Special issue call for papers: Viral Biophysics.
In the New and Notable "Deciphering the mechanics of spindle positioning,"
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
www.cell.com
January 15, 2026 at 7:01 PM
In the New and Notable "Deciphering the mechanics of spindle positioning,"
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Like tiny “energy carts” in a factory shifting to busy assembly lines when orders (glucose) flood in, mitochondria in beta cells move toward the edge on glucose cues to power insulin release!
www.cell.com
January 15, 2026 at 3:04 PM
Like tiny “energy carts” in a factory shifting to busy assembly lines when orders (glucose) flood in, mitochondria in beta cells move toward the edge on glucose cues to power insulin release!
Experimental determination of backbone conformational change entropy on helix formation by model peptides—a step to better understand protein folding.
www.cell.com
January 14, 2026 at 7:01 PM
Experimental determination of backbone conformational change entropy on helix formation by model peptides—a step to better understand protein folding.
Fast adaptation in hearing? A viscoelastic model validated by experiments, explains receptor-current sensitivity, hysteresis, phase leads, high-pass filtering, and dynamic range in outer hair bundles.
www.cell.com
January 14, 2026 at 3:04 PM
Fast adaptation in hearing? A viscoelastic model validated by experiments, explains receptor-current sensitivity, hysteresis, phase leads, high-pass filtering, and dynamic range in outer hair bundles.
#OPENACCESS: Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell. Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, and Shankar Mukherji.
www.cell.com
January 13, 2026 at 8:03 PM
#OPENACCESS: Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell. Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, and Shankar Mukherji.