BioTechniques
@biotechniques.bsky.social
BioTechniques, part of Taylor and Francis, is an open access journal and website, providing the latest news and research in life science methods | Est. 1983
At @elrig.org’s Drug Discovery 2025, we learned about how Yanyan Zhao and her colleagues at the University of Cambridge have approached the preclinical development of a PET imaging tracer to achieve earlier Alzheimer’s disease diagnosis >>> www.biotechniques.com/imaging/prob... 🧪
Probing the brain for answers: a PET tracer for early Alzheimer’s diagnosis
Yanyan Zhao shares an insight into the preclinical development of a PET imaging tracer for catching Alzheimer’s disease earlier.
www.biotechniques.com
November 27, 2025 at 2:11 PM
At @elrig.org’s Drug Discovery 2025, we learned about how Yanyan Zhao and her colleagues at the University of Cambridge have approached the preclinical development of a PET imaging tracer to achieve earlier Alzheimer’s disease diagnosis >>> www.biotechniques.com/imaging/prob... 🧪
Researchers have used cryo-EM to capture how the GRP94 protein enlists the help of other proteins to ensure it forms properly and suggested a way to target it for future disease treatments >>> www.biotechniques.com/proteomics/c... 🧪
Cryo-EM captures the protein that recruits its own bodyguards
Researchers have discovered how the GRP94 protein enlists the help of other proteins to shield it from glycosylation.
www.biotechniques.com
November 27, 2025 at 10:29 AM
Researchers have used cryo-EM to capture how the GRP94 protein enlists the help of other proteins to ensure it forms properly and suggested a way to target it for future disease treatments >>> www.biotechniques.com/proteomics/c... 🧪
The latest biotech industry updates >>> www.biotechniques.com/molecular-bi... 🧪
The biotech bi-weekly: nucleic acid purification, metabolic heart failure research and AI-designed bispecific binding proteins
In this edition of the biotech bi-weekly, we highlight the latest exciting product launches, partnerships and company events.
www.biotechniques.com
November 26, 2025 at 10:20 AM
The latest biotech industry updates >>> www.biotechniques.com/molecular-bi... 🧪
At @elrig.org’s Drug Discovery 2025, we spoke with Rebecca Goss – Professor at the University of St Andrews and CEO of X-Genix – to learn more about her precision molecular editing platform and what it could mean for drug discovery >>> www.biotechniques.com/bioengineeri... 🧪
Tapping into the precision molecule-editing potential of halogenases
We spoke to Rebecca Goss to learn more about her precision molecular editing platform and its potential for drug development.
www.biotechniques.com
November 25, 2025 at 4:14 PM
At @elrig.org’s Drug Discovery 2025, we spoke with Rebecca Goss – Professor at the University of St Andrews and CEO of X-Genix – to learn more about her precision molecular editing platform and what it could mean for drug discovery >>> www.biotechniques.com/bioengineeri... 🧪
Scientists have engineered a nanowire platform that mimics brain tissue to study astrocytes, the star-shaped cells critical for brain health, for the first time in their natural state >>> www.biotechniques.com/bioengineeri... 🧪
An innovative way to study astrocytes' signature star shape
Researchers have developed a nanowire platform for studying astrocytes in their natural state, providing an insight into brain health.
www.biotechniques.com
November 25, 2025 at 3:11 PM
Scientists have engineered a nanowire platform that mimics brain tissue to study astrocytes, the star-shaped cells critical for brain health, for the first time in their natural state >>> www.biotechniques.com/bioengineeri... 🧪
The same technology used in COVID-19 vaccines could help prevent muscle damage from snakebites >>> www.biotechniques.com/drug-discove... 🧪
Could a vaccine prevent snakebite-induced muscle damage?
Researchers have harnessed mRNA-lipid nanoparticle vaccines to deliver antibody fragments to prevent snakebite-induced muscle damage.
www.biotechniques.com
November 24, 2025 at 4:31 PM
The same technology used in COVID-19 vaccines could help prevent muscle damage from snakebites >>> www.biotechniques.com/drug-discove... 🧪
In this interview from @elrig.org’s #DD25, @namshik.bsky.social explains quantum algorithms with a London Tube analogy, how they can be applied to benefit drug discovery and his advice for researchers wanting to launch their own startups >>> www.biotechniques.com/computationa...
Quantum questions have algorithmic answers: navigating a drug discovery network
In this interview, Namshik Han explains the role quantum algorithms can play in drug discovery research and what makes a successful startup.
www.biotechniques.com
November 20, 2025 at 2:24 PM
In this interview from @elrig.org’s #DD25, @namshik.bsky.social explains quantum algorithms with a London Tube analogy, how they can be applied to benefit drug discovery and his advice for researchers wanting to launch their own startups >>> www.biotechniques.com/computationa...
Researchers have demonstrated that dissolving precursor protein clusters hindered the formation of tau fibrils in solution, offering an insight into neurodegenerative protein aggregation >>> www.biotechniques.com/neuroscience... 🧪
Probing precursor polymers for information about pathological proteins
Researchers have demonstrated that dissolving precursor protein clusters hindered the formation of tau fibrils in solution.
www.biotechniques.com
November 20, 2025 at 10:21 AM
Researchers have demonstrated that dissolving precursor protein clusters hindered the formation of tau fibrils in solution, offering an insight into neurodegenerative protein aggregation >>> www.biotechniques.com/neuroscience... 🧪
Researchers at @scripps.edu have demonstrated that PIEZO1 and PIEZO2 play key roles in sensing mechanical forces during childbirth >>> www.biotechniques.com/molecular-bi... 🧪
The physical cues coordinating childbirth
Researchers have demonstrated that PIEZO1 and PIEZO2 play key roles in sensing physical forces during childbirth.
www.biotechniques.com
November 18, 2025 at 3:55 PM
Researchers at @scripps.edu have demonstrated that PIEZO1 and PIEZO2 play key roles in sensing mechanical forces during childbirth >>> www.biotechniques.com/molecular-bi... 🧪
Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments >>> www.biotechniques.com/crispr/regul... 🧪
Regulating the gene essential to immune system balance
Researchers have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.
www.biotechniques.com
November 17, 2025 at 4:16 PM
Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments >>> www.biotechniques.com/crispr/regul... 🧪
For the first time, researchers have captured the chameleon’s coiled optic nerve using contrast enhanced computed tomography >>> www.biotechniques.com/imaging/the-... 🧪
The coiled history of the chameleon optic nerve
Researchers have shown that the chameleon has a coiled optic nerve, which they believe allows the lizard to increase their field of vision.
www.biotechniques.com
November 14, 2025 at 11:28 AM
For the first time, researchers have captured the chameleon’s coiled optic nerve using contrast enhanced computed tomography >>> www.biotechniques.com/imaging/the-... 🧪
Researchers have discovered a vulnerability in the bacteria that cause Lyme disease >>> www.biotechniques.com/molecular-bi... 🧪
Manganese: a double-edged sword in Lyme disease
Researchers uncovered that disrupting manganese in the bacteria that cause Lyme disease could be key to weakening the pathogen.
www.biotechniques.com
November 13, 2025 at 3:18 PM
Researchers have discovered a vulnerability in the bacteria that cause Lyme disease >>> www.biotechniques.com/molecular-bi... 🧪
In the STEM Tea podcast, @phdgprotein86.bsky.social sits down with Lindsey Keith-Vincent, Associate Dean at Louisiana Tech University, to explore her unique model for supporting faculty, mentoring students and fostering a culture of authenticity >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Humans first, professionals second
In this episode, AJ Hinton is joined by Lindsey Keith-Vincent, a first-generation college graduate who is passionate about STEM education.
www.biotechniques.com
November 13, 2025 at 12:07 PM
In the STEM Tea podcast, @phdgprotein86.bsky.social sits down with Lindsey Keith-Vincent, Associate Dean at Louisiana Tech University, to explore her unique model for supporting faculty, mentoring students and fostering a culture of authenticity >>> www.biotechniques.com/podcasts/ste... 🧪
The latest biotech industry insights >>> www.biotechniques.com/molecular-bi... 🧪
The biotech bi-weekly: protein quantification, AMR mutation characterization and automating single-cell transcriptomics
In this edition of the biotech bi-weekly, read about recent product launches that are quantifying His-tagged proteins and characterizing AMR mutations.
www.biotechniques.com
November 12, 2025 at 10:00 AM
The latest biotech industry insights >>> www.biotechniques.com/molecular-bi... 🧪
At @elrig.org’s Drug Discovery 2025, we spoke to Heather Pinkett – President of The Protein Society – to learn more about ABC transporters and what targeting them could mean for combatting antimicrobial resistance >>> www.biotechniques.com/microbiology... 🧪
Targeting ABC to tackle AMR: taking advantage of bacterial membrane proteins
Heather Pinkett tells us about her research investigating ABC transporters in pathogenic bacteria and what this could mean for tackling AMR.
www.biotechniques.com
November 11, 2025 at 3:01 PM
At @elrig.org’s Drug Discovery 2025, we spoke to Heather Pinkett – President of The Protein Society – to learn more about ABC transporters and what targeting them could mean for combatting antimicrobial resistance >>> www.biotechniques.com/microbiology... 🧪
Researchers have discovered that the enzyme NUDT5 helps to switch off purine production – the chemical pathway that generates the building blocks of DNA – but does so without using its enzymatic activity >>> www.biotechniques.com/molecular-bi... 🧪
Enzyme scaffold restricts key pathway in DNA synthesis
Researchers have discovered that the enzyme NUDT5 utilizes its structure to exercise metabolic control over a key pathway in DNA synthesis.
www.biotechniques.com
November 11, 2025 at 12:02 PM
Researchers have discovered that the enzyme NUDT5 helps to switch off purine production – the chemical pathway that generates the building blocks of DNA – but does so without using its enzymatic activity >>> www.biotechniques.com/molecular-bi... 🧪
Researchers from Texas Tech University have developed a method that could allow scientists to bypass one of the most time-consuming and technically challenging steps in plant biotechnology – tissue culture >>> www.biotechniques.com/plant-climat... 🧪
A synthetic regeneration cascade for genetically editing crops
Researchers have developed a synthetic regeneration system for genetically editing crops, avoiding the challenging step of tissue culturing.
www.biotechniques.com
November 10, 2025 at 3:56 PM
Researchers from Texas Tech University have developed a method that could allow scientists to bypass one of the most time-consuming and technically challenging steps in plant biotechnology – tissue culture >>> www.biotechniques.com/plant-climat... 🧪
Two separate studies have identified age-related molecular changes in the rat brain and adjusted them to improve memory >>> www.biotechniques.com/neuroscience... 🧪
CRISPR for improving memory in aging brains
Researchers have used CRISPR gene editing to adjust age-related molecular mechanisms to target memory loss.
www.biotechniques.com
November 6, 2025 at 4:04 PM
Two separate studies have identified age-related molecular changes in the rat brain and adjusted them to improve memory >>> www.biotechniques.com/neuroscience... 🧪
How paradigm-shifting could an AI-first drug discovery company be?
At @elrig.org’s Drug Discovery 2025, we spoke to Miles Congreve, Chief Scientific Officer at @isomorphiclabs.bsky.social, to find out >>> www.biotechniques.com/drug-discove... 🧪
At @elrig.org’s Drug Discovery 2025, we spoke to Miles Congreve, Chief Scientific Officer at @isomorphiclabs.bsky.social, to find out >>> www.biotechniques.com/drug-discove... 🧪
How will AI-first drug design transform human health?
Find out how developments in AlphaFold 3, alongside new predictive models, are changing approaches to drug discovery and design.
www.biotechniques.com
November 6, 2025 at 2:22 PM
How paradigm-shifting could an AI-first drug discovery company be?
At @elrig.org’s Drug Discovery 2025, we spoke to Miles Congreve, Chief Scientific Officer at @isomorphiclabs.bsky.social, to find out >>> www.biotechniques.com/drug-discove... 🧪
At @elrig.org’s Drug Discovery 2025, we spoke to Miles Congreve, Chief Scientific Officer at @isomorphiclabs.bsky.social, to find out >>> www.biotechniques.com/drug-discove... 🧪
By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, researchers have found a way to force tumors to trigger their own destruction >>> www.biotechniques.com/cancer-resea... 🧪
A cancer cell’s mRNA guide to self-sabotage
Researchers have harnessed the cGAS-STING pathway using mRNA to slow tumor growth in mouse models of cancer.
www.biotechniques.com
November 5, 2025 at 12:06 PM
By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, researchers have found a way to force tumors to trigger their own destruction >>> www.biotechniques.com/cancer-resea... 🧪
A new study provides unprecedented insights into the cellular architecture of over 200 species of plankton using ultrastructure expansion microscopy >>> www.biotechniques.com/imaging/expa... 🧪
Expanding our insights into the planktonic universe
Researchers have utilized ultrastructure expansion microscopy to reveal more about the cytoskeletal characteristics of the planktonic universe.
www.biotechniques.com
November 4, 2025 at 4:07 PM
A new study provides unprecedented insights into the cellular architecture of over 200 species of plankton using ultrastructure expansion microscopy >>> www.biotechniques.com/imaging/expa... 🧪
Cryo-electron tomography has captured how synaptic vesicles transmit information across synapses > > > www.biotechniques.com/neuroscience... 🧪
Neurons ‘kiss-shrink-run’ to relay information
Cryo-ET reveals the 'kiss-shrink-run' fusion model to explain how neurons transmit signals across synapses.
www.biotechniques.com
November 3, 2025 at 3:58 PM
Cryo-electron tomography has captured how synaptic vesicles transmit information across synapses > > > www.biotechniques.com/neuroscience... 🧪
🧟 Researchers have developed a way to tag senescent ‘zombie’ cells that allows for both identification and characterization of these cells, which are often implicated in disease >>> www.biotechniques.com/cell-and-tis... 🧪
Hunting zombie cells: novel technique for tagging senescent cells
Researchers have developed a new technique for tagging senescent cells with DNA aptamers to identify and characterize these cells.
www.biotechniques.com
October 31, 2025 at 11:01 AM
🧟 Researchers have developed a way to tag senescent ‘zombie’ cells that allows for both identification and characterization of these cells, which are often implicated in disease >>> www.biotechniques.com/cell-and-tis... 🧪
An AI tool identifies cells that can shed light on the earliest origins of cancer through a game of molecular ‘laser tag’ >>> www.biotechniques.com/computationa... 🧪
Molecular laser tag: identifying chromosomal abnormalities with AI
Researchers have developed an AI-assisted technology that can identify and tag chromosomal abnormalities in cells.
www.biotechniques.com
October 29, 2025 at 4:07 PM
An AI tool identifies cells that can shed light on the earliest origins of cancer through a game of molecular ‘laser tag’ >>> www.biotechniques.com/computationa... 🧪
An electromagnetic device can gently sort cells by levitating them to different heights >>> www.biotechniques.com/cell-and-tis... 🧪
Just like magic: the technique behind cellular levitation
Researchers have developed a novel electromagnetic cell sorting technique for separating different cell types.
www.biotechniques.com
October 29, 2025 at 2:49 PM
An electromagnetic device can gently sort cells by levitating them to different heights >>> www.biotechniques.com/cell-and-tis... 🧪