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Brian King @briankingneo.bsky.social · Mar 31

Dr. Gomez Zaghmout will be joined by Dr. Valentine (Trial Investigator) and Dr. Wally Carlo
Trial link: tinyurl.com/27ud5cpz @ebneo.bsky.social #neobluesky #neoEBM @mattiewolfmd.bsky.social

A cluster randomized trial of xylitol chewing gum for prevention of preterm birth: The PPaX trial

Valentine et al. conducted an open-label, parallel-enrollment, matched-pair, cluster-randomized trial of 10,069 pregnant participants from eight randomization sites in Malawi. When compared to active ...

tinyurl.com

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Brian King @briankingneo.bsky.social · Mar 31

Our next webinar is on April 3rd, at 4:00 pm EST! Register here - uab.zoom.us/meeting/regist…
Dr. Gomez Zaghmout (Neonatal-Perinatal Fellow, University of Miami) will present the PPaX Trial, a cluster randomized trial of xylitol chewing gum in Malawi to prevent preterm birth.

Note: Since your browser does not support JavaScript, you must press the Continue button once to proceed.

https://uab.zoom.us/meeting/regist…

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Brian King @briankingneo.bsky.social · Mar 31

The most recent AAP SONPM Journal Club webinar is available - youtu.be/beh82Mgor7Q
Dr. Aung (Neonatal-Perinatal Fellow, St. Christopher's Hospital) gave an excellent overview of the PLUSS trial. Thank you to @drbretty.bsky.social and Dr. Watterberg for joining! #neobluesky

AAP SONPM Journal Club - March 19th, 2025 - PLUSS Trial

YouTube video by Neo TECaN

youtu.be

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Brian King @briankingneo.bsky.social · Mar 28

Thank you.

Particularly when choosing to share it already. If you want to keep it until publication, don't submit it to the largest pediatric conference in the USA (or world?).

At that point, the only group that benefits from not sharing it further is the conference.

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Brian King @briankingneo.bsky.social · Mar 12

I'm certainly no nutrition expert so defer to you and others - but surely length is still ultimately a surrogate short term outcome?

At 2 years, or 5 years is our "primary outcome" (concern) the baby's height? Or how that growth impacted brain development (and subsequently neurodevelopment)?

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Brian King @briankingneo.bsky.social · Mar 11

Join us for our next Journal Club, next Wednesday (March 19th) at 6:00 pm EST - uab.zoom.us/meeting/regist…
Neonatal-Perinatal Fellow Htay Aung, MD will review the Pluss Trial joined by Dr. Brett Manley and Dr. Kristi Watterberg#neoblueskyky

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Brian King @briankingneo.bsky.social · Mar 11

If you missed it, check out the latest AAP Neonatal Journal Club - youtu.be/0_iqc78Fh5c
@arichaimd.bsky.social provided an excellent review of the BeNeDuctus Trial, with great learning points by Tim Hundscheid and @jslaughtermd.bsky.social #neobluesky #neoEBM

AAP SONPM Journal Club - February 27, 2025 - BeNeDuctus Trial

YouTube video by Neo TECaN

youtu.be

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Reposted by Brian King

Evidence-based Neonatology @ebneo.bsky.social · Mar 6

A large cohort study @WHOBulletin suggests no evidence of increased risk of BPD following birth dose hepatitis b vaccination in preterm infants buff.ly/rRPi3Gl

#neobluesky #neoEBM #EBNEOalerts

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Brian King @briankingneo.bsky.social · Mar 4

If your work is meaningful, it will still be shared. Human nature. It will be "word of mouth". I think we all know how well that goes.

Sharing actual content (poster, slides) allows your views on the work to be heard more accurately.

Brian King @briankingneo.bsky.social · Mar 4

You're already sharing your work, potentially to several hundred. They have all paid for access (and you've paid for the privilege).

Many can't because of the funds required (Hawaii is expensive!) or simply because they are doing the important work back home (patient care).

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Brian King @briankingneo.bsky.social · Mar 4

As you start to think about presenting your work #PAS2025, this is another year where the decision to share is delegated to you.

Think about who research is for (patients, families, all clinicians). Gatekeeping access is counterproductive #neobluesky #neosky #neoEBM

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Brian King @briankingneo.bsky.social · Mar 4

#neobluesky #neosky

I've noticed when tagging accounts the list that comes up in a post is noticeably worse than some other platforms and finding who I want. It appears there is little preference to those I follow.

Anyone found any settings that change this?

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Brian King @briankingneo.bsky.social · Feb 26

@jslaughtermd.bsky.social @mattiewolfmd.bsky.social

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Brian King @briankingneo.bsky.social · Feb 26

Excited for the first AAP SONPM Journal Club Webinar tomorrow at 3:00 pm EST. @arichaimd.bsky.social will present the Beneductus Trial, with Tim Hundscheid and Jon Slaughter joining as mentors. Register here shorturl.at/w7lZf #neobluesky @ebneo.bsky.social #neoEBM

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Brian King @briankingneo.bsky.social · Feb 24

Preterm cooling trial published, previously presented at PAS 2023.

No difference in primary outcome. Bayesian analysis suggests 87% probability of increased risk of death with hypothermia. Practice changing for those who are cooling this population?

#neobluesky

jamanetwork.com/journals/jam...

Whole-Body Hypothermia for Neonatal Encephalopathy

This randomized clinical trial investigates if hypothermia initiated at less than 6 hours after birth reduces the probability of death or disability at 18 to 22 months’ corrected age in infants 33 to ...

jamanetwork.com

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Brian King @briankingneo.bsky.social · Feb 21

Validation is done within the same dataset - that's obviously important, but external validation more so especially given such wide variation in PDA practices.

Lastly - predicting an outcome doesn't mean we can change the outcome. Would want to show that acting on the score prevents surgery.

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Brian King @briankingneo.bsky.social · Feb 21

Difficult to find the enrollment period in this paper - found it by downloading the original cohort paper (2015-2016).

Is this PDA surgery, or device closure? If actually surgery, it doesn't reflect practice in most places IMO. I've not seen a surgical closure in ~6 years.

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Brian King @briankingneo.bsky.social · Feb 4

Looks like Bluesky also doesn't have an edit feature.

Brian King @briankingneo.bsky.social · Feb 4

I'm Vienna it sounded like it maybe wasn't going to be ready by PAS. I haven't looked through the program yet.

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Brian King @briankingneo.bsky.social · Feb 3

FEED1 trial should be presented this year I think, which will hopefully provide compelling confirmatory data of this practice in a much larger trial.

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Brian King @briankingneo.bsky.social · Jan 30

Yes that's totally reasonable. Look forward to the larger cohort.

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Brian King @briankingneo.bsky.social · Jan 30

Thanks!
Multivariable analysis will be helpful in a larger cohort (how much does the GA diff account for the score diff?)

Could also include measures of prediction (AUC, Sens/Spec). Assume you used the same score cut off as in previous papers. Could a different cut off predict AKI better?

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Brian King @briankingneo.bsky.social · Jan 30

Thanks for sharing!

It says the score was calculated on DOL2 but none received PDA treatment until >7 days - is that your standard practice? Or is this excluding those who met your treatment criteria before 7 days?

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Brian King @briankingneo.bsky.social · Jan 25

Thanks for sharing! Looking forward to reading!

I often think about what society is willing to invest at the beginning of life, compared to what we invest on the aging generation. Not saying we shouldn't do both, but Pediatric/Neonatal care offers an incredible "return on investment".

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Reposted by Brian King

Gabriel Altit - NeoCardioLab @cardioneo.bsky.social · Jan 25

Everyone should read this piece: "What Is the Relative Value of a Baby?" | New England Journal of Medicine
@canadianpreemies.bsky.social @99nicu.bsky.social @ebneo.bsky.social
www.nejm.org/doi/full/10....

What Is the Relative Value of a Baby? | NEJM

As she cares for a newborn who’s struggling to breathe, a neonatologist contemplates how politics and power structures affect the availability of critical perinatal services in the United States.

www.nejm.org

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