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Caghan Kizil @cakizil.bsky.social · May 22

Congratulations to all authors! This work was supported by several federal and private research grants. We thank the patients and families for their participation.

@columbiauniversity.bsky.social

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Caghan Kizil @cakizil.bsky.social · May 22

... isogenic iPSC-derived human cells, mouse models, and #human brain tissues show the universal importance and validity of these disease pathways. Targeting these pathologies may open promising therapeutic avenues to slow #Alzheimer’s disease progression.

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Caghan Kizil @cakizil.bsky.social · May 22

This rigidity may exacerbate the breakdown blood-brain barrier, an important structure regulating the clearance and basic health of the #brain. Our results provide further evidence linking vascular pathology to AD progression. Our validation in other large cohorts, ++

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Caghan Kizil @cakizil.bsky.social · May 22

We identified unique molecular changes in various cell types that regulate the interaction between brain cells and blood vessels. An important cell type, #astrocytes, adopt a hyper-adhesive, mechanically rigid states at the #vascular interface with #APOE-ε4.

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Caghan Kizil @cakizil.bsky.social · May 22

▶️ #Preprint @medrxivpreprint.bsky.social on our novel multiome resource from 52 #human brains of Hispanic ancestry, known to bear high vascular pathology. In @elanuryilmaz.bsky.social et al., we analyzed the effects of #APOE-ε4, a strong genetic risk factor for #Alzheimer's.

doi.org/10.1101/2025...

Single-nucleus multiomics in brains from Hispanic individuals reveal APOE-ε4-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology

The apolipoprotein E4 allele (APOEϵ4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet its molecular impact on cerebrovascular biology remains inconclusive, particular...

doi.org

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Caghan Kizil @cakizil.bsky.social · Dec 31

#2024Recap
2024 was an amazing year for #KizilLab with impactful publications, awards, patent applications, and discoveries with #zebrafish. These wouldn't be possible without our excellent team, collaborators, supporters &
@columbiauniversity.bsky.social. Big thanks! 💙 Looking fwd to more in 2025!🌟

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Caghan Kizil @cakizil.bsky.social · Dec 25

Wherever you are and whichever of the diverse celebrations you observe today, 🎄 Merry #Christmas , 🕎 Happy #Hanukkah, 🕯️ Happy #Kwanzaa, 🌞 Blessed #Yule and any other holiday you celebrate this season.This must remind us of the shared values of humanity and unity in diversity. #HappyHolidays

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Reposted by Caghan Kizil

Nature Portfolio @natureportfolio.nature.com · Nov 29

Using X/Twitter data from nine countries, a study in Nature Communications shows that out-group mentions use more toxic language than in-group mentions, and political mentions are more toxic than apolitical mentions. https://go.nature.com/417N7KG 🧪

This is figure 2, which shows that political interaction networks are structurally polarized in each of the nine countries studied.

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Caghan Kizil @cakizil.bsky.social · Dec 5

Thank you Jingli🥰

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Reposted by Caghan Kizil

Caghan Kizil @cakizil.bsky.social · Dec 4

🚨 Our new study out in @natureportfolio.bsky.social! 🌟
We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟

More about how this changes what we know about heart functionality.
#Zebrafish #Neuroscience #LittleBrain

doi.org/10.1038/s414...

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system - Nature Communications

Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...

doi.org

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Caghan Kizil @cakizil.bsky.social · Dec 4

This was a collaborative effort from teams at @karolinskainst.bsky.social and @columbiauniversity.bsky.social. Congratulations to all authors, including our own @elanuryilmaz.bsky.social and Prabesh Bhattarai! 🙌

Thanks for the generous support of our funding agencies 🙏

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Caghan Kizil @cakizil.bsky.social · Dec 4

Why it matters:
This research challenges the idea that the heart is just a simple relay, positioning the IcNS as a key player in rhythm generation. A leap toward new therapeutic strategies for arrhythmia and heart failure.

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Caghan Kizil @cakizil.bsky.social · Dec 4

🔑Highlights:
- Pacemaker-like neurons in the IcNS, generating rhythmic activity autonomously 🧠💓
- A complex diversity of neurotransmitter systems finely tuning heart rhythms 🔬
- Ex-vivo study of intact neural heart networks 🧪

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Caghan Kizil @cakizil.bsky.social · Dec 4

🚨 Our new study out in @natureportfolio.bsky.social! 🌟
We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟

More about how this changes what we know about heart functionality.
#Zebrafish #Neuroscience #LittleBrain

doi.org/10.1038/s414...

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system - Nature Communications

Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...

doi.org

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Caghan Kizil @cakizil.bsky.social · Nov 30

Saturday evening #cat

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Caghan Kizil @cakizil.bsky.social · Nov 29

Our review on multi-target drugs and their use in Alzheimer's disease in Trends in Pharmacological Sciences @cellpress.bsky.social

doi.org/10.1016/j.ti...

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Caghan Kizil @cakizil.bsky.social · Nov 29

kizillab.org/2024/06/20/c...

Collaborative Study on Molecular Insights into Blood-Brain Barrier Dysfunction in Alzheimer’s Disease Published

We are thrilled to announce our participation in a groundbreaking study in collaboration with Mayo Clinic, now published in Nature Communications. This research looks into the intricate role of blo…

kizillab.org

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Caghan Kizil @cakizil.bsky.social · Nov 29

kizillab.org/2024/08/26/o...

Our project received Translational Therapeutics Accelerator Award

We are glad to announce that we received a Translational Therapeutics Accelerator (TRx) Pilot Award, which provides resources to position therapeutic discoveries for future commercial value. T…

kizillab.org

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Caghan Kizil @cakizil.bsky.social · Nov 29

www.cell.com/cell-genomic...

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling

In this study, Tayran et al. investigate the role of ABCA7, certain genetic variants of which act as risk factors for Alzheimer’s disease (AD), using a zebrafish AD model. They demonstrate that ABCA7-...

www.cell.com

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Caghan Kizil @cakizil.bsky.social · Nov 21

Congratulations to all authors and thanks to supporting agencies.

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Caghan Kizil @cakizil.bsky.social · Nov 21

www.cuimc.columbia.edu/news/study-s...

#NewPublication
Changes in ABCA7 gene links to a greater risk of Alzheimer’s, but it was unclear how the variants advance the disease. We have discovered how variants of the ABCA7 gene, which are common among Black Americans, increase the risk for Alzheimer’s.

Study Shows How Common Genetic Variants in Black Americans Increase Alzheimer’s Risk

Variants of the ABCA7 gene accelerate neurodegeneration by reducing the amount of neuropeptide Y, a protein essential for maintaining brain synapses.

www.cuimc.columbia.edu

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Caghan Kizil @cakizil.bsky.social · Nov 21

kizillab.org/2024/04/10/w...

We found a genetic variant that protects against Alzheimer’s disease

We discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting hundreds of thousands of people from the disease. The discovery of the pro…

kizillab.org

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Caghan Kizil @cakizil.bsky.social · Nov 21

kizillab.org/2024/10/07/o...

Our publication received the McAlpine Foundation for Neuroscience Research Award

We are proud to announce that our recent publication where we identified a protective genetic variant in FN1 gene against Alzheimer’s disease received a recognition award from McAlpine Founda…

kizillab.org

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