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calcinottolab.bsky.social
CalcinottoLab
@calcinottolab.bsky.social
85 followers 110 following 7 posts
We pioneer next-generation immunotherapy by blocking pro-tumoral immune activity. Our research uncovers how tumor cells, microbiota, and immune infiltrates drive hormone-dependent and BRCA-mutated cancers. https://ior.usi.ch/group/cancer-immunotherapy
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Jul 31
🚀 Excited to share our latest publication!
👉 www.nature.com/articles/s41...
A fantastic collaboration with an incredible team.

#BreastCancer #Neutrophils #TumorMicroenvironment #PARPinhibitors #DNARepair #NatureCommunications #CancerImmunology #CalcinottoLab
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition - Nature Communications
Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologou...
www.nature.com
2 6
Reposted by CalcinottoLab
iorbellinzona.bsky.social
Institute of Oncology Research (IOR) @iorbellinzona.bsky.social · Aug 19
#IORnews
The Cancer Immunotherapy lab, led by Prof. A. Calcinotto, uncover a new immune–tumor interaction in ER+ breast cancer, opening the way for targeted therapies.

🔗Read more: ior.usi.ch/events-news/...

@calcinottolab.bsky.social
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Jul 31
🚀 Excited to share our latest publication!
👉 www.nature.com/articles/s41...
A fantastic collaboration with an incredible team.

#BreastCancer #Neutrophils #TumorMicroenvironment #PARPinhibitors #DNARepair #NatureCommunications #CancerImmunology #CalcinottoLab
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition - Nature Communications
Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologou...
www.nature.com
2 6
calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Jun 17
Join us for the session “DNA Repair and Immunosurveillance” at #EACR2025, where I’ll be giving a talk on neutrophils and synthetic lethality in breast cancer”
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · May 8
Senescent neutrophils: a hidden role in cancer progression: Trends in Cell Biology www.cell.com/trends/cell-...
Senescent neutrophils: a hidden role in cancer progression
Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body o...
www.cell.com
2
calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Apr 27
Getting ready to start!
Join us for this session #AACR2025 where I will be speaking alongside Nicky McGranahan and Ronny Drapkin.
Looking forward to an exciting discussion on how immunology shapes cancer initiation!
1:00 p.m. - 2:30 p.m. — see you there!
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Apr 21
Thrilled to share that our group will be presenting at a major symposium at the AACR Annual Meeting in Chicago this Sunday!

Catch us at AACR—Chicago, we’re ready!
#AACR25 #CancerResearch #Immunology #SomaticEvolution #EarlyDetection #CancerBiology #TeamScience #SeeYouInChicago
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Apr 16
Bellinzona is ready to host the next SYIS seminar on April 17!
I’m excited to join the event as a speaker, alongside Christian Pasquali from OM Pharma.
Join us at 5:00 pm (CET) — either in person in Bellinzona or online via Zoom!
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calcinottolab.bsky.social
CalcinottoLab @calcinottolab.bsky.social · Apr 15
Thrilled to share our new review published by @cp-trendscellbio.bsky.social
In this article, my lab explores the heterogeneity of cancer neutrophils and discusses their implications in both cancer progression and therapy resistance. Check out the full review here:
pubmed.ncbi.nlm.nih.gov/39362804/
Senescent neutrophils: a hidden role in cancer progression - PubMed
Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body o...
pubmed.ncbi.nlm.nih.gov
1 3