Clinician-scientists at St. Jude Children’s Research Hospital and collaborators have conducted the largest study of infant-type hemispheric glioma ever reported, uncovering key factors that could be used to guide treatment strategies for this rare pediatric brain tumor. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in […]

FDA Commissioner Marty Makary and Vinay Prasad, FDA’s chief medical and scientific officer and director of the agency’s Center for Biologics Evaluation and Research, jointly published a letter in The New England Journal of Medicine spelling out the rationale for FDA’s new “plausible mechanism pathway,” aimed at getting bespoke therapies to market without the need […]

The nagging pain in Mia Sandino’s right knee set in in September 2018, and throughout her freshman year at the University of Washington, she tried to ignore it. “Iwas being a very naive and invincible-feeling 19-year-old,” Sandino told The Cancer Letter. “I didn’t put two and two together that this area of the knee that […]

FDA has approved Hyrnuo (sevabertinib), an oral, reversible, tyrosine kinase inhibitor, for the treatment of adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer whose tumors have HER2 tyrosine kinase domain activating mutations, as detected by an FDA-approved test, and who have received a prior systemic therapy. To access this subscriber-only content […]

This editorial has been adapted from “Drugs and the FDA: Safety, Efficacy, and the Public’s Trust.” Rick Pazdur, MD, the newly appointed director for the Center for Drug Evaluation and Research at the FDA, has been described as “greyhound thin” as a result of his dedication to cycling and lifting weights in the gym each […]

Darrow Zeidenstein was named chief development officer at the American Cancer Society and its advocacy affiliate the American Cancer Society Cancer Action Network. In this role, Zeidenstein will lead the organization’s development efforts, overseeing all aspects of resource generation, including corporate partnerships, philanthropy, planned giving, Discovery Shops, community-based fundraising, and revenue-generating field operations. To access […]

About one in eight adults (12%) say that they are currently taking a GLP-1 drug such as Ozempic or Wegovy either to lose weight or treat a chronic condition, an increase from 18 months ago, though the high costs of the medications remain a concern, a KFF Health Tracking Poll finds. To access this subscriber-only […]

Edward Chu was an expert in pharmacology whose research improved therapies for colorectal cancer, leading to the identification of new treatment targets and driving scientific advances in the field. His understanding of cancer centers—how they are structured and how they operate—led many institutions to reach their highest potential. His ability to make complicated concepts seem […]

FDA approved epcoritamab-bysp with lenalidomide and rituximab for relapsed or refractory follicular lymphoma. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled in sponsored accounts.Login Subscribe

Natalie Phelps, a 43-year-old mother of two, died Nov. 9 from colorectal cancer. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled in sponsored accounts.Login Subscribe

Two months into his job as CEO of the American Cancer Society and American Cancer Society Cancer Action Network, Shane Jacobson is still in the drinking-water-from-the-firehose stage of the job. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored […]

This editorial has been adapted from “Drugs and the FDA: Safety, Efficacy, and the Public’s Trust.” Rick Pazdur, MD, the newly appointed director for the Center for Drug Evaluation and Research at the FDA, has been described as “greyhound thin” as a result of his dedication to cycling and lifting weights in the gym each […]

FDA approved Poherdy (pertuzumab-dpzb) as an interchangeable biosimilar to Perjeta (pertuzumab). This is the first approval of a biosimilar for Perjeta. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled in sponsored accounts.Login […]

GLP-1 receptor agonists—the class of drugs behind Ozempic, Wegovy, and Mounjaro—may do more than regulate blood sugar and weight. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled in sponsored accounts.Login Subscribe

The nagging pain in Mia Sandino’s right knee set in in September 2018, and throughout her freshman year at the University of Washington, she tried to ignore it. “Iwas being a very naive and invincible-feeling 19-year-old,” Sandino told The Cancer Letter. “I didn’t put two and two together that this area of the knee that […]

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An NIH employee who has been publicly critical of the Trump administration’s health policies said she was placed on “nondisciplinary” administrative leave when she returned to work Nov. 13 after the government reopened. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register […]

Arnold Daniel “Arnie” Kaluzny, PhD, longtime adviser to NCI and an early pioneer and contributor to what is now known as health services research, died Oct. 29 at the age of 87. Dr. Kaluzny was professor emeritus of health policy and management in the University of North Carolina Gillings School of Global Public Health, a […]

FDA granted full approval to Imdelltra (tarlatamab-dlle) for the treatment of adult patients with extensive stage small cell lung cancer with disease progression on or after platinum-based chemotherapy. The decision to convert Imdelltra’s prior accelerated approval to a full approval is based on data from the global phase III DeLLphi-304 study. To access this subscriber-only […]

Arnold Daniel “Arnie” Kaluzny, PhD, longtime adviser to NCI and an early pioneer and contributor to what is now known as health services research, died Oct. 29 at the age of 87. Dr. Kaluzny was professor emeritus of health policy and management in the University of North Carolina Gillings School of Global Public Health, a […]

This editorial has been adapted from “Drugs and the FDA: Safety, Efficacy, and the Public’s Trust.” Rick Pazdur, MD, the newly appointed director for the Center for Drug Evaluation and Research at the FDA, has been described as “greyhound thin” as a result of his dedication to cycling and lifting weights in the gym each […]

The Mount Sinai Tisch Cancer Center received the Comprehensive Cancer Center designation from NCI. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled in sponsored accounts.Login Subscribe

Approximately one in 30 NIH-funded clinical trials—and more than 74,000 trial participants—were affected by grant funding disruptions caused by the Trump administration, according to an analysis in JAMA Internal Medicine. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored […]