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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt
@castiglionelab.bsky.social
24 followers 43 following 5 posts
Assistant Professor, Biological Sciences, Ophthalmology & Visual Sciences| Genomics, biochemistry, evolution| www.castiglionelab.com
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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 28
Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social

www.science.org/doi/10.1126/...
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
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Reposted by The Castiglione Lab @ Vanderbilt
sciencenews.bsky.social
Science News @sciencenews.bsky.social · May 7
Scientists are using ancient works of art to piece together a critically endangered species’ past.
Ancient poems document the decline of the Yangtze finless porpoise
The porpoise is critically endangered. Ancient Chinese poems reveal the animal’s range has dropped about 65 percent over the past 1,400 years.
buff.ly
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Reposted by The Castiglione Lab @ Vanderbilt
fractalecho.bsky.social
Rua M. Williams @fractalecho.bsky.social · May 3
If you're a grad student or an undergrad interested in research I need to you listen to me very carefully.

You cannot learn to write good research papers if you do not read good research papers.

Stop asking LLMs to summarize papers for you.
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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 29
Thrilled to be featured on the BBC! (21:25)
www.bbc.co.uk/sounds/play/... @science.org
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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 28
www.science.org/content/arti...
Genetic surprise gives horses exceptional endurance
A mutation that should have cut a protein short instead makes it more sensitive to the stress of exercise
www.science.org
castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 28
www.popsci.com/environment/...
Scientists discover why horses are such exceptional athletes
The genetic switch that 'really lets horses have their cake and eat it too.’
www.popsci.com
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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 28
www.npr.org/2025/03/27/n...
A new study reveals the genetic change that made horses so athletic
A genetic change that boosts a cell's aerobic capacity while also protecting it from excess stress could explain how horses became such powerful athletes, according to a new study in Science.
www.npr.org
castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt @castiglionelab.bsky.social · Mar 28
Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social

www.science.org/doi/10.1126/...
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
12 47
Reposted by The Castiglione Lab @ Vanderbilt
evolutionvu.bsky.social
Evolutionary Studies at Vanderbilt @evolutionvu.bsky.social · Mar 27
🏇 Horses evolved a viral trick to outrun damage.
@castiglionelab.bsky.social found a rare mutation that supercharges muscle energy—without the usual side effects.
New study out in Science. Read our press release >> loom.ly/FUbYSu0

🔬 #evolution #genetics #Science2025
Gianni Castiglione stands in a lab at Vanderbilt University surrounded by scientific equipment, including pipettes, a centrifuge, and ice buckets. He wears glasses and a light blue button-down shirt, smiling slightly with one hand at his side. A caption in a black box reads: “New research from the Castiglione Lab shows how one rare mutation supercharged equine energy.” The Evolutionary Studies Initiative logo is in the top right corner, and a purple border outlines the image.
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