Mike Cheetham
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cheethamlab.bsky.social
Mike Cheetham
@cheethamlab.bsky.social
82 followers 87 following 14 posts
Retinal cell biologist studying IRDs.
Likes organoids, Alfa Romeo and Leeds United
Posts Replies Media Videos
cheethamlab.bsky.social
Classic cars near the Rudolfinum Prague #RD20205 @bwjones.bsky.social
September 18, 2025 at 12:30 PM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
We’ll done Owen 👏 great talk at @rd2025.bsky.social in Prague
September 17, 2025 at 12:59 PM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
Amazing science being presented @rd2025.bsky.social including from our team @ucleye.bsky.social 🧫🧬🧪🔬
September 17, 2025 at 1:06 PM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
We’ll done Davide 👏 excellent talk @rd2025.bsky.social
September 17, 2025 at 1:01 PM
Reposted by Mike Cheetham
adamrutherford.bsky.social
An absolute scam. Does this serve science? No it does not.

www.thebookseller.com/news/springe...
Springer Nature's revenue increases to €926m as adjusted operating profit soars
Springer Nature's group revenue has risen by 6% to €926m (£800m) in the first half of 2025, while adjusted operating profit (AOP) was up by 10% to €241m (£208m).
www.thebookseller.com
August 14, 2025 at 10:04 PM
Reposted by Mike Cheetham
ucleye.bsky.social
Everyone at @ucleye.bsky.social has been deeply saddened by the passing of a highly esteemed colleague in June 2025. www.ucl.ac.uk/news/2025/ju...
Tribute to eye treatment pioneer Professor Pete Coffey
UCL colleagues have paid tribute to world-leading eye researcher Professor Pete Coffey, who pioneered a treatment enabling people whose vision had been destroyed by disease to see again.
www.ucl.ac.uk
July 22, 2025 at 10:56 AM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
Congratulations Freddie on your PhD defence 🎉🥳 huge thank to the examiners Chris Inglehearn and Dan Gore 🙏
July 11, 2025 at 11:18 AM
Reposted by Mike Cheetham
amandajcarr.bsky.social
It’s incredibly hard to express what Professor Pete Coffey meant to so many of us. The Macular Society has written a beautiful tribute to Pete and I'm honoured to have contributed a few words.

Thank you, my friend, for so many happy days.

www.macularsociety.org/about/media/...
Tributes paid to pioneering eye researcher Professor Pete Coffey
Tributes have been paid to one of the world’s top eye researchers, Professor Pete Coffey, who has sadly passed away after a long illness.
www.macularsociety.org
July 7, 2025 at 3:51 PM
Reposted by Mike Cheetham
ucleye.bsky.social
Our Deputy Director Prof Alison Hardcastle @hardcastlelab.bsky.social, features in the video of the launch of a new Centre of Excellence for eye health in Warsaw: a partnership between @ucleye.bsky.social, ICTER, and the Institut de la Vision at Université Sorbonne. www.ucl.ac.uk/ioo/news/202...
IoO represented at launch of Poland's new teaming project
The official ceremony launched three new Teaming for Excellence projects funded by the European Union under the Horizon Europe framework programme for research and innovation.
www.ucl.ac.uk
March 10, 2025 at 3:23 PM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
Now in print and open access. Thanks @ajhgnews.bsky.social for feature in Editors Corner 🧪🧫🧬
March 6, 2025 at 5:31 PM
Reposted by Mike Cheetham
jcorralserrano.bsky.social
I'm very proud and happy to share our work of many (many!) years, on a novel ARL3-G70E variant, linked to IRD. 🎉

📖 Read the full paper here:

academic.oup.com/hmg/advance-...
#ARL3 #retina #cilia #RPE #organoids

🧵
A novel recurrent ARL3 variant c.209G > A p.(Gly70Glu) causes variable non-syndromic dominant retinal dystrophy with defective lipidated protein transport in human retinal stem cell models
Abstract. Inherited retinal dystrophies (IRDs) are characterized by their high clinical and genetic heterogeneity. Despite significant advances in the iden
academic.oup.com
March 3, 2025 at 7:45 PM
Reposted by Mike Cheetham
jcorralserrano.bsky.social
🧪 We modelled this variant for the first time using human stem cell derived RPE and retinal organoids, showing ciliary trafficking defects that are not present in other cell types (like skin fibroblasts).
March 3, 2025 at 7:52 PM
Reposted by Mike Cheetham
elfridedebaere.bsky.social
Big thank you 🙏 to Julio Corral-Serrano @cheethamlab.bsky.social @carlorivolta.bsky.social @hardcastlelab.bsky.social @elfridedebaere.bsky.social & many colleagues. Funded by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social ‪@iobswiss.bsky.social‬ @ugent-fge.bsky.social JTC EJPRD Solve-RET FWO
March 3, 2025 at 2:37 PM
Reposted by Mike Cheetham
cheethamlab.bsky.social
And @hardcastlelab.bsky.social supported by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social and many others
March 3, 2025 at 12:16 PM
cheethamlab.bsky.social
And @hardcastlelab.bsky.social supported by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social and many others
March 3, 2025 at 12:16 PM
cheethamlab.bsky.social
Delighted to be part of this study led by Julio Corral-Serrano with @elfridedebaere.bsky.social and @carlorivolta.bsky.social
March 3, 2025 at 12:13 PM
cheethamlab.bsky.social
academic.oup.com/hmg/advance-...
A novel recurrent ARL3 variant c.209G > A p.(Gly70Glu) causes variable non-syndromic dominant retinal dystrophy with defective lipidated protein transport in human retinal stem cell models
Abstract. Inherited retinal dystrophies (IRDs) are characterized by their high clinical and genetic heterogeneity. Despite significant advances in the iden
academic.oup.com
March 3, 2025 at 12:10 PM
Reposted by Mike Cheetham
moorfieldsbrc.bsky.social
This #RareDiseaseDay join our #Research Roadshow at Moorfields!

Today: 14:00 - 16:00 @ Opposite Costa - Moorfields

Cheetham lab: Discover how genes can both cause problems and offer solutions.

#RetinitisPigmentosa #LeberCongenitalAmaurosis & #DominantOpticAtrophy
@moorfieldsfriends.bsky.social
Two women stand next to a scientific poster on inherited blindness and treatment research, smiling at the camera. One wears a green sweater with a lanyard and ID badge, while the other wears a blue striped shirt. A banner for Moorfields Biomedical Research Centre is visible to the right, and the setting appears to be a research or healthcare facility.
February 28, 2025 at 2:32 PM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
www.bbc.co.uk/news/article...
Gene therapy experiment treats rare childhood blindness - BBC News
Four toddlers born with a rare eye condition have seen "life-changing improvements", say UK doctors.
www.bbc.co.uk
February 21, 2025 at 7:54 AM
Reposted by Mike Cheetham
hardcastlelab.bsky.social
Amazing results of gene therapy in very young children from @ucleye.bsky.social 👏👏 www.thelancet.com/journals/lan...
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
Our findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...
www.thelancet.com
February 21, 2025 at 7:53 AM
cheethamlab.bsky.social
Thanks to @moorfieldsbrc.bsky.social Moorfields Eye Charity @wellcometrust.bsky.social @fightblindness.bsky.social Fight for Sight amongst others for support.
February 13, 2025 at 3:02 PM
cheethamlab.bsky.social
actaneurocomms.biomedcentral.com/articles/10.... Delighted to share a paper from Michael Whitehead and the rest of the team on OPA1 mediated dominant optic atrophy.
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells - Acta Neuropathologica Communications
Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variant...
actaneurocomms.biomedcentral.com
February 13, 2025 at 2:57 PM
cheethamlab.bsky.social
Thanks to @fightblindness.bsky.social @wellcometrust.bsky.social and @moorfieldsbrc.bsky.social for support amongst others and all the staff @ucleye.bsky.social
February 12, 2025 at 8:19 AM
cheethamlab.bsky.social
Delighted to share our new publication on modelling childhood blindness in retinal organoids and rescue of some of the phenotypes with small molecules great work by Dimitra Athanasiou and the team actaneurocomms.biomedcentral.com/articles/10....
Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids - Acta Neuropathologica Communications
Bialleleic pathogenic variants in LCA5 cause one of the most severe forms of Leber congenital amaurosis, an early-onset retinal disease that results in severe visual impairment. Here, we report the us...
actaneurocomms.biomedcentral.com
February 12, 2025 at 8:15 AM
Reposted by Mike Cheetham
moorfieldsbrc.bsky.social
A study in @ajhgnews.bsky.social has discovered a genetic cause of a rare eye condition called X-linked inherited retinal dystrophy. Innovation solved a ten-year mystery across three generations.

🔗 buff.ly/42IS7pD

Audio description: buff.ly/4gxivWK
hardcastlelab.bsky.social‬ @ucleye.bsky.social
An infographic titled 'Research Simplified' showcases four significant advances in retinal research with icons for visual emphasis: A target icon denotes 'Genetic cause of rare inherited retinal dystrophy discovered.' An eye icon represents 'Stem cell technology and lab-grown retinas reveal genetic clues.' A DNA strand icon highlights 'Jumping chromosomes disrupt how genes work.' A handshake icon symbolizes 'Paving the way for earlier diagnosis.' The footer features the NIHR Moorfields Biomedical Research Centre logo.
February 7, 2025 at 9:22 AM