Alison Cheung
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Alison Cheung
@cheungalison.bsky.social
7 followers 9 following 30 posts
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#OTILT Rifaximin is minimally absorbed in the GI tract & can reduce ammonia-producing bacteria, making it an option for hepatic encephalopathy. It can maintain remission more effectively than placebo www.nejm.org/doi/full/10.... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Rifaximin Treatment in Hepatic Encephalopathy | NEJM
Hepatic encephalopathy is a chronically debilitating complication of hepatic cirrhosis. The efficacy of rifaximin, a minimally absorbed antibiotic, is well documented in the treatment of acute hepa...
www.nejm.org
September 4, 2025 at 5:44 PM
#OTILT Candida auris is a resistant yeast that causes invasive infections by evading elimination via cleaning & formation of dry biofilm. Echinocandins are the recommended initial therapy pmc.ncbi.nlm.nih.gov/articles/PMC... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities
Candida auris, a recently recognized, often multidrug-resistant yeast, has become a significant fungal pathogen due to its ability to cause invasive infections and outbreaks in healthcare facilities w...
pmc.ncbi.nlm.nih.gov
September 3, 2025 at 5:34 PM
#OTILT Lefamulin was a new antibiotic that was an effective alternative to treat tetracycline- & macrolide-resistant Ureaplasma spp. & Mycoplasma hominis but was not profitable with no interested buyer after the company fell pmc.ncbi.nlm.nih.gov/articles/PMC... cen.acs.org/pharmaceutic...
August 29, 2025 at 11:03 PM
#OTILT In indigenous pts, 3-dose a week of ceftriaxone in HD pts is less likely to lead to toxic exposures compared to QD dosing, recommended for a infection w a MIC =<1 in those w bilirubin =>10 academic.oup.com/jac/article/... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Validating a novel three-times-weekly post-hemodialysis ceftriaxone regimen in infected Indigenous Australian patients—a population pharmacokinetic study
AbstractObjectives. To describe the total and unbound population pharmacokinetics of a 2 g three-times-weekly post-dialysis ceftriaxone regimen in Indigeno
academic.oup.com
August 28, 2025 at 10:38 PM
#OTILT Initial go-to treatment for toxoplasma encephalitis was pyrimethamine + leucovorin (for bone marrow suppression reduction), but since the price is high ($750/pill), TMP-SMX is preferred clinicalinfo.hiv.gov/en/guideline... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
clinicalinfo.hiv.gov
August 27, 2025 at 5:41 PM
#OTILT Infection rate of breast tissue expander range from 2.5 to 24%. Biofilm bugs can make it hard to treat - daptomycin is preferred over linezolid d/t increase activity within biofilm www.journalofinfection.com/article/S016... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
www.journalofinfection.com
August 26, 2025 at 4:52 PM
#OTILT Kluyvera ascorbata is a rare gram-negative bacillus that reportedly caused septic shock via UTI, life-threatening in immunocompromised pts. Ceftriaxone can be a safe empiric option pmc.ncbi.nlm.nih.gov/articles/PMC... @bwdionne.bsky.social @jeffpears0n.bsky.social @chrisoh1.bsky.social
Kluyvera ascorbata: An Unusual Cause of Septic Shock in a Patient With Urothelial Cancer
Kluyvera ascorbata is a gram-negative bacillus which is a rare cause of clinically significant infections in humans. We report a rare case of K. ascorbata infection causing septic shock in a patient w...
pmc.ncbi.nlm.nih.gov
August 25, 2025 at 8:32 PM
#OTILT Step-down to oral minocycline has appeared to be effective in complicated pyelonephritis infected with ESBL enterobacterales, but MICs >= 4 ug/mL may be associated with more recurrence www.sciencedirect.com/science/arti... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
August 22, 2025 at 3:34 PM
#OTILT Aztreonam/avibactam is an option for treating metallo-beta-lactamase producing bacteria, which are resistant to carbapenems. AVI helps ATM efficacy against MBL by protecting it from others pubmed.ncbi.nlm.nih.gov/39528085/ @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Aztreonam and avibactam combination therapy for metallo-β-lactamase-producing gram-negative bacteria: A Narrative Review - PubMed
This review provides insights into the potential clinical management implications of ATM-AVI for treating carbapenem-resistant gram-negative infections, particularly those caused by MBL-producing orga...
pubmed.ncbi.nlm.nih.gov
August 21, 2025 at 5:08 PM
#OTILT In pts undergoing CAR-T therapy, antibiotics pre treatment was associated with poor outcomes. 2/3 of pts were on antibiotics post-treatment & longer course is associated w/ CRS & ICANS ashpublications.org/blood/articl... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Impact of Broad-Spectrum Antibiotic Exposure on CAR-T Therapy Outcomes in B-Cell Lymphoma: A Multicenter International Study
Disclosures. Ghilardi:Vittoria Biotherapeutics: Honoraria. Peled:MaaT Pharma: Consultancy; Canaccord Genuity, Inc: Consultancy; Postbiotics Plus Research:
ashpublications.org
August 20, 2025 at 9:19 PM
#OTILT Pseudomonas is a prevalent bug in pts w/ CF, leading to chronic infection. New antibiotic formulations include inhaled levofloxacin, combination fosfomycin + tobramycin, & liposomal amikacin academic.oup.com/femsle/artic... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
Current and future therapies for Pseudomonas aeruginosa infection in patients with cystic fibrosis
This provides an overview of current and emerging treatments for Pseudomonas aeruginosa airway infection in cystic fibrosis patients, and explains the trea
academic.oup.com
August 19, 2025 at 4:39 PM
#OTILT S.maltophilia is a common colonizer of the respiratory tract. Despite evidence that it causes significant mortality, a positive respiratory culture has less significant meaning. There was no difference in outcomes in treatment and non-treatment group. publications.ersnet.org/content/erj/...
August 18, 2025 at 5:30 PM
#OTILT Tetracycline resistance in N. gonorrhoeae has been increasing. More than 3 DoxyPEP doses have been found to be associated with high-level resistance and more colonization with tetR S.aureus academic.oup.com/cid/article-... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
August 15, 2025 at 4:48 PM
#OTILT In patients with HIV/AIDS w oropharyngeal candidiasis, liquid fluconazole was more effective & quicker at eradicating candida and had a lower relapse rate than liquid nystatin academic.oup.com/cid/article/... @bwdionne.bsky.social @chrisoh1.bsky.social @jeffpears0n.bsky.social
August 13, 2025 at 2:57 PM
#OTILT Ertapenem is highly protein-bound drug. When used in patients with hypoalbuminemia (<2.5 g/dL), ertapenem was associated with an increased mortality compared to imipenem & meropenem. Risk of death quintupled when albumin was 2 g/dL compared to 4 g/dL pubmed.ncbi.nlm.nih.gov/25636928/
August 12, 2025 at 5:00 PM
#OTILT Vancomycin is used as empiric therapy for pts with neutropenic fever but often is inconsistent with the IDSA guidelines such as continuing therapy for more than 3 days without gram-positive blood cultures or without a clinically appropriate indication pmc.ncbi.nlm.nih.gov/articles/PMC...
August 11, 2025 at 4:52 PM
#OTILT CHROMagar is a plating tool designed for detection & differential of Candida species, changing color depending on the species (ex. blue for C.auris). This was 60% sensitive & 100% specific when compared to the gold standard @chrisoh1.bsky.social journals.asm.org/doi/10.1128/...
Evaluation of CHROMagar Candida Plus for the detection of C. auris with a panel of 206 fungal isolates and 83 colonization screening skin-swabs | Microbiology Spectrum
Candida auris is an emerging fungal pathogen of public health concern. As it continues to spread, it is important to publish evaluations of new diagnostic tools. In this study, we share our experience...
journals.asm.org
August 8, 2025 at 4:33 PM
#OTILT People who inject drugs with infective endocarditis have worse mortality rates (26%), reflecting inadequate addiction care. Self-directed discharges play a factor in this high rate (5-22% compared to 2%) pmc.ncbi.nlm.nih.gov/articles/PMC... @chrisoh1.bsky.social @bwdionne.bsky.social
Infective endocarditis in persons who use drugs: Epidemiology, current management, and emerging treatments
pmc.ncbi.nlm.nih.gov
August 7, 2025 at 4:36 PM
#OTILT Current practice for candidiasis treatment is more based on inference than evidence. From clinical data, step down to oral therapy between 4-7 days after IV initiation is appropriate for a total of 14 days. pmc.ncbi.nlm.nih.gov/articles/PMC... @chrisoh1.bsky.social @bwdionne.bsky.social
August 6, 2025 at 8:10 PM
#OTILT Moxifloxacin reversibly inhibits hERG potassium channels in a dose- and voltage-dependent manner to prolong QTc. Mutations of pore-S6 residue Tyr652 to Ala can reduce moxifloxacin block by 66% pmc.ncbi.nlm.nih.gov/articles/PMC... @chrisoh1.bsky.social @bwdionne.bsky.social
August 5, 2025 at 4:29 PM
Complications associated with acute pyelonephritis in pregnant patients include pre-term labor, sepsis, acute respiratory failure and even death. The highest concomitant diagnoses were anemia and diabetes. www.tandfonline.com/doi/full/10.... @chrisoh1.bsky.social @bwdionne.bsky.social
August 4, 2025 at 2:55 PM
Drug fever induced by parenteral beta-lactams typically starts as a low grade fever followed by a high & remittent fever. Penicillin-induced fever had the highest incidence, while cefazolin-induced had the lowest @chrisoh1.bsky.social @bwdionne.bsky.social pubmed.ncbi.nlm.nih.gov/2815075/
August 1, 2025 at 4:05 PM
HIV patients w/ CD4 count>200 but CD4% <14 are less likely to be prescribed PJP prophylaxis compared to those with a CD4 count<200 & CD4% >14. This discordance occurs in 16-25% of HIV patients. Important to monitor both pmc.ncbi.nlm.nih.gov/articles/PMC... @chrisoh1.bsky.social @bwdionne.bsky.social
The Impact of Absolute CD4 Count and Percentage Discordance on Pneumocystis Jirovecii Pneumonia Prophylaxis in HIV-Infected Patients
Current guidelines suggest that HIV-infected patients should receive chemoprophylaxis against Pneumocystis jirovecii pneumonia (PJP) if they have a cluster determinant 4 (CD4) count <200 cells/mm3 or ...
pmc.ncbi.nlm.nih.gov
July 31, 2025 at 4:31 PM
#OTILT When looking at oral step-down therapy for uncomplicated UTI with E.coli and Klebsilella, fluoroquinolones & Bactrim have similar effectiveness while high-bioavailable beta-lactams had higher recurrence rates @chrisoh1.bsky.social @bwdionne.bsky.social
academic.oup.com/ofid/article...
Oral β-Lactams, Fluoroquinolones, or Trimethoprim-Sulfamethoxazole for Definitive Treatment of Uncomplicated Escherichia coli or Klebsiella Species Bacteremia From a Urinary Tract Source
Oral stepdown with fluoroquinolones or trimethoprim-sulfamethoxazole had similar effectiveness for uncomplicated GN-BSI from a urinary source. High-bioavai
academic.oup.com
July 30, 2025 at 5:08 PM
#OTILT PJP can affect patients with systemic lupus erythematosus. Incidence rate of 1.8 cases/1000 PYs & adverse effects of prophylaxis support giving therapy for only those with risk of lung disease. www.jrheum.org/content/52/1... @chrisoh1.bsky.social @bwdionne.bsky.social
Incidence of Pneumocystis jirovecii Pneumonia and Prophylaxis-Associated Adverse Events Among Patients With Systemic Lupus Erythematosus
Objective Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection that may affect patients with systemic lupus erythematosus (SLE). The objective of this project was to describe the incid...
www.jrheum.org
July 29, 2025 at 5:09 PM