Rosen Lab
@cjrosenlab.bsky.social
Official Acct: Dr. Cliff Rosen's group researching the metabolic & biochemical fate of marrow stromal cells as progenitor osteoblasts & adipocytes at MaineHealth
What are the mechanisms of weight loss induced bone loss? Check out our recent review of the current literature on the mechanistic pathways and clinical consequences of weight loss–induced bone loss:
doi.org/10.1038/s414...
doi.org/10.1038/s414...
December 5, 2025 at 3:15 PM
What are the mechanisms of weight loss induced bone loss? Check out our recent review of the current literature on the mechanistic pathways and clinical consequences of weight loss–induced bone loss:
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Huge congratulations to Dr. Victoria DeMambro, recipient of the 2025 Soft Bones Maher Family Research Grant for hypophosphatasia! This grant will support her research to understand underlying causes of muscle weakness & chronic fatigue symptoms in adult HPP patients
lnkd.in/eutXHxNK
lnkd.in/eutXHxNK
December 4, 2025 at 3:21 PM
Huge congratulations to Dr. Victoria DeMambro, recipient of the 2025 Soft Bones Maher Family Research Grant for hypophosphatasia! This grant will support her research to understand underlying causes of muscle weakness & chronic fatigue symptoms in adult HPP patients
lnkd.in/eutXHxNK
lnkd.in/eutXHxNK
Congratulations to lab member, Linyi Liu, on his recent promotion to Staff Scientist I! 🎉
November 3, 2025 at 4:44 PM
Congratulations to lab member, Linyi Liu, on his recent promotion to Staff Scientist I! 🎉
Shoutout to our lab manager, Phuong, for representing the Rosen lab in the MHIR Costume Contest and securing first place!! 🥇🎉
October 31, 2025 at 9:33 PM
Shoutout to our lab manager, Phuong, for representing the Rosen lab in the MHIR Costume Contest and securing first place!! 🥇🎉
Happy Halloween from the Rosen lab! @demambrove.bsky.social @carolynchlebek.bsky.social
October 31, 2025 at 8:57 PM
Happy Halloween from the Rosen lab! @demambrove.bsky.social @carolynchlebek.bsky.social
How does calorie restriction change the skeleton in obese mice? Check out our latest paper, out now in Bone. Spoiler: calorie restriction leads to bone loss and shifts the metabolome in the cortex! Congratulations, @carolynchlebek.bsky.social
doi.org/10.1016/j.bo...
doi.org/10.1016/j.bo...
October 29, 2025 at 7:26 PM
How does calorie restriction change the skeleton in obese mice? Check out our latest paper, out now in Bone. Spoiler: calorie restriction leads to bone loss and shifts the metabolome in the cortex! Congratulations, @carolynchlebek.bsky.social
doi.org/10.1016/j.bo...
doi.org/10.1016/j.bo...
New lab photo for the Rosen lab! 📸
October 28, 2025 at 3:35 PM
New lab photo for the Rosen lab! 📸
Curious about how weight loss strategies affect bone health in patients with obesity? Check out this recent review article published in #JBMR @asbmr.bsky.social
doi.org/10.1093/jbmr...
doi.org/10.1093/jbmr...
Effects of weight-loss interventions on bone health in people living with obesity
Abstract. Strategies to reduce weight in people living with obesity (PwO) include calorie restriction, metabolic and bariatric surgery (MBS), and anti-obes
doi.org
October 27, 2025 at 1:40 PM
Curious about how weight loss strategies affect bone health in patients with obesity? Check out this recent review article published in #JBMR @asbmr.bsky.social
doi.org/10.1093/jbmr...
doi.org/10.1093/jbmr...
Earlier this month, medical student Stephanie Lam represented the Rosen lab at the University of New England College of Medicine's Fall Research Forum! Stephanie shared her findings on changes to animal behavior during caloric restriction, generated through her work with @carolynchlebek.bsky.social
October 20, 2025 at 1:26 PM
Earlier this month, medical student Stephanie Lam represented the Rosen lab at the University of New England College of Medicine's Fall Research Forum! Stephanie shared her findings on changes to animal behavior during caloric restriction, generated through her work with @carolynchlebek.bsky.social
We are excited to have Samuel Rubin continue in our lab as a Research Assistant I! Sam started with us as a part-time learner and is now managing an independent research project - go, Sam! Stay tuned to hear about all his exciting research.
September 15, 2025 at 6:36 PM
We are excited to have Samuel Rubin continue in our lab as a Research Assistant I! Sam started with us as a part-time learner and is now managing an independent research project - go, Sam! Stay tuned to hear about all his exciting research.
Lots of fun at #ASBMR2025! We’re excited for another great day! @asbmr.bsky.social
September 7, 2025 at 4:47 PM
Lots of fun at #ASBMR2025! We’re excited for another great day! @asbmr.bsky.social
Huge congrats to lab member @demambrove.bsky.social on a fantastic talk this morning at #ASBMR2025! 🎉🦴 if you didn’t get a chance to ask your question at the session, be sure to find Dr. DeMambro at this meeting! @asbmr.bsky.social
September 5, 2025 at 9:08 PM
Huge congrats to lab member @demambrove.bsky.social on a fantastic talk this morning at #ASBMR2025! 🎉🦴 if you didn’t get a chance to ask your question at the session, be sure to find Dr. DeMambro at this meeting! @asbmr.bsky.social
Huge thanks to @natalieasims.bsky.social for featuring Dr. DeMambro’s abstract during this morning’s session! We are also so excited for this presentation! Join us at noon in Room 6E (TODAY!) #ASBMR2025 @asbmr.bsky.social
September 5, 2025 at 5:48 PM
Huge thanks to @natalieasims.bsky.social for featuring Dr. DeMambro’s abstract during this morning’s session! We are also so excited for this presentation! Join us at noon in Room 6E (TODAY!) #ASBMR2025 @asbmr.bsky.social
Planning out which amazing @asbmr.bsky.social sessions you want to hit tomorrow? Be sure to go to Room 6E tomorrow at noon to hear about treating adult HPP mice with Ilofotase Alfa from @demambrove.bsky.social! (Abstract #1020) Plus so many other great rare bone talks in this session! 🦴
September 5, 2025 at 4:16 AM
Planning out which amazing @asbmr.bsky.social sessions you want to hit tomorrow? Be sure to go to Room 6E tomorrow at noon to hear about treating adult HPP mice with Ilofotase Alfa from @demambrove.bsky.social! (Abstract #1020) Plus so many other great rare bone talks in this session! 🦴
Are you at the @asbmr.bsky.social /RBDA Symposium on Rare Bone Diseases? Check out Dr. DeMambro’s poster on Ilofotase Alfa treatment in adult HPP mice, which was recognized by a Pre-Meeting Young Investigator Travel Grant for the top Young Investigators presenting today 🎉
September 4, 2025 at 6:16 PM
Are you at the @asbmr.bsky.social /RBDA Symposium on Rare Bone Diseases? Check out Dr. DeMambro’s poster on Ilofotase Alfa treatment in adult HPP mice, which was recognized by a Pre-Meeting Young Investigator Travel Grant for the top Young Investigators presenting today 🎉
Interested in the role of bone in whole-body energy metabolism? Check out this recent review in @natrevendo.nature.com ! Co-authored by lab leader, Dr. Cliff Rosen 🦴
August 26, 2025 at 4:02 PM
Interested in the role of bone in whole-body energy metabolism? Check out this recent review in @natrevendo.nature.com ! Co-authored by lab leader, Dr. Cliff Rosen 🦴
Reposted by Rosen Lab
Calling all #ASBMR2025 attendees! Do you have a stunning image, video, or graphical abstract that reveals the beauty and complexity of the musculoskeletal system?
📣Announcing an image competition!
📣Announcing an image competition!
August 26, 2025 at 3:46 PM
Calling all #ASBMR2025 attendees! Do you have a stunning image, video, or graphical abstract that reveals the beauty and complexity of the musculoskeletal system?
📣Announcing an image competition!
📣Announcing an image competition!
We love seeing our lab members featured in the MHIR Newsletter! Congrats, again Dr. DeMambro! 🎉
August 12, 2025 at 5:32 PM
We love seeing our lab members featured in the MHIR Newsletter! Congrats, again Dr. DeMambro! 🎉
We are SO excited that Dr. Victoria DeMambro successfully defended her PhD 🎉 Dr. DeMambro’s thesis, entitled “Tissue Nonspecific Alkaline Phosphatase: more than a pro-mineralizing enzyme”, focused on hypophosphatasia 🦴
July 24, 2025 at 1:34 AM
We are SO excited that Dr. Victoria DeMambro successfully defended her PhD 🎉 Dr. DeMambro’s thesis, entitled “Tissue Nonspecific Alkaline Phosphatase: more than a pro-mineralizing enzyme”, focused on hypophosphatasia 🦴
We are SO excited to welcome Dr. Madhura Nijsure @madhura0327.bsky.social to the Rosen lab this week! As a postdoc, she is excited to explore how diet and nutrition influence bone health and homeostasis at the molecular level. Stay tuned for her amazing research!
July 9, 2025 at 6:11 PM
We are SO excited to welcome Dr. Madhura Nijsure @madhura0327.bsky.social to the Rosen lab this week! As a postdoc, she is excited to explore how diet and nutrition influence bone health and homeostasis at the molecular level. Stay tuned for her amazing research!
Can the new wave of GLP1 medications be useful for treating Type 1 Diabetes? Check out this editorial and the associated articles in the @nejm.org to learn more!
evidence.nejm.org/doi/abs/10.1...
evidence.nejm.org/doi/abs/10.1...
Semaglutide for Type I Diabetes — A New Twist on an Old Story
The obesity epidemic is about three decades old, and it has taken a devastating toll across the world, leading to an increase in type 2 diabetes, worsened cardiovascular outcomes, and increased rat...
evidence.nejm.org
June 30, 2025 at 1:29 PM
Can the new wave of GLP1 medications be useful for treating Type 1 Diabetes? Check out this editorial and the associated articles in the @nejm.org to learn more!
evidence.nejm.org/doi/abs/10.1...
evidence.nejm.org/doi/abs/10.1...
Looking for a fun Friday read? Check out our most recent paper exploring the inflammatory responses and lipid metabolism in bone marrow adipocytes after high calorie feeding and fasting in humans! Huge congratulations to Dr. Costa & team for such exciting work!
doi.org/10.3389/fend...
doi.org/10.3389/fend...
June 27, 2025 at 1:45 PM
Looking for a fun Friday read? Check out our most recent paper exploring the inflammatory responses and lipid metabolism in bone marrow adipocytes after high calorie feeding and fasting in humans! Huge congratulations to Dr. Costa & team for such exciting work!
doi.org/10.3389/fend...
doi.org/10.3389/fend...
We are excited to welcome #UNECOM student Stephanie Lam to the Rosen lab! Stephanie will be working with @carolynchlebek.bsky.social to understand the effects of calorie restriction on bone and other organ systems.
June 23, 2025 at 6:23 PM
We are excited to welcome #UNECOM student Stephanie Lam to the Rosen lab! Stephanie will be working with @carolynchlebek.bsky.social to understand the effects of calorie restriction on bone and other organ systems.
Congratulations to the @asbmr.bsky.social Harold M. Frost Young Investigator Award recipients! We are excited to see our own @carolynchlebek.bsky.social among the awardees 🎉 Attend the @orssociety.bsky.social Musculoskeletal Biology Workshop to hear from the awardees about their exciting research!
June 18, 2025 at 1:38 PM
Congratulations to the @asbmr.bsky.social Harold M. Frost Young Investigator Award recipients! We are excited to see our own @carolynchlebek.bsky.social among the awardees 🎉 Attend the @orssociety.bsky.social Musculoskeletal Biology Workshop to hear from the awardees about their exciting research!