Centre for Medicines Discovery
@cmd.ox.ac.uk
A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.
Reposted by Centre for Medicines Discovery
New in @natcomms.nature.com: a live-cell BRET biosensor to study how PRMT5 inhibitors engage their target in a tumour-context cellular environment (1/4)
Open access paper: doi.org/10.1038/s414...
Open access paper: doi.org/10.1038/s414...
A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells - Nature Communications
This study presents a BRET biosensor that measures how anticancer drugs cooperatively engage PRMT5 complexes in cells, revealing how cellular metabolites such as SAM and MTA enhance drug action and en...
doi.org
December 5, 2025 at 9:11 AM
New in @natcomms.nature.com: a live-cell BRET biosensor to study how PRMT5 inhibitors engage their target in a tumour-context cellular environment (1/4)
Open access paper: doi.org/10.1038/s414...
Open access paper: doi.org/10.1038/s414...
Reposted by Centre for Medicines Discovery
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 7:30 PM
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
Researchers from the Centre for Medicines Discovery delivered a successful public engagement event at the 2025 Green Man Festival. Their 'Medicine-Making Express' stall demystified the drug discovery journey for a national audience, engaging over 900 visitors.
www.cmd.ox.ac.uk/news/cmd-dri...
www.cmd.ox.ac.uk/news/cmd-dri...
September 19, 2025 at 9:39 AM
Researchers from the Centre for Medicines Discovery delivered a successful public engagement event at the 2025 Green Man Festival. Their 'Medicine-Making Express' stall demystified the drug discovery journey for a national audience, engaging over 900 visitors.
www.cmd.ox.ac.uk/news/cmd-dri...
www.cmd.ox.ac.uk/news/cmd-dri...
Reposted by Centre for Medicines Discovery
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
July 21, 2025 at 7:07 PM
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
Cryo-EM studies by the Bullock group @cmd.ox.ac.uk reveal how phase II drug UM171 and cancer mutations similarly reshape E3 ligase KBTBD4 to recruit neosubstrate HDAC1/2. This unexpected structural mimicry may inspire future degrader discovery. #TPD #CancerBiology rdcu.be/egdFy
April 4, 2025 at 1:22 PM
Cryo-EM studies by the Bullock group @cmd.ox.ac.uk reveal how phase II drug UM171 and cancer mutations similarly reshape E3 ligase KBTBD4 to recruit neosubstrate HDAC1/2. This unexpected structural mimicry may inspire future degrader discovery. #TPD #CancerBiology rdcu.be/egdFy
The ODDI has been featured in a Wall Street Journal article, describing the use of AI in identifying and stratifying novel targets for therapeutic intervention in Alzheimer’s disease.
www.wsj.com/articles/ai-...
www.wsj.com/articles/ai-...
AI-Powered Databases Boost the Alzheimer’s Drug Discovery Process
Researchers studying Alzheimer’s disease are using artificial intelligence-powered databases to accelerate the drug discovery process by making it easier to sift through vast amounts of biomedical dat...
www.wsj.com
April 1, 2025 at 10:49 AM
The ODDI has been featured in a Wall Street Journal article, describing the use of AI in identifying and stratifying novel targets for therapeutic intervention in Alzheimer’s disease.
www.wsj.com/articles/ai-...
www.wsj.com/articles/ai-...
Georgie Maynard and brother Charlie - LibDem MP for Witney, visited the Centre for Medicines Discovery, University of Oxford Brain Tumour Charity/CRUK funded research team led by Prof Daniel Ebner working on a five-year study to identify existing cancer drugs could shrink glioblastoma brain tumours.
March 31, 2025 at 1:49 PM
Georgie Maynard and brother Charlie - LibDem MP for Witney, visited the Centre for Medicines Discovery, University of Oxford Brain Tumour Charity/CRUK funded research team led by Prof Daniel Ebner working on a five-year study to identify existing cancer drugs could shrink glioblastoma brain tumours.