Corina Anastasaki
@corinaanast.bsky.social
79 followers
75 following
8 posts
Research Assistant Professor @ WashU Medicine interested in cancer neuroscience, low grade glioma modeling and hiPSCs
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Neuron
@cp-neuron.bsky.social
· Sep 1
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present during neurodevelopment, using aberrant glutamate receptor stimulation to activate PDGFRα/ERK via Src. This uncovers a molecular link between neurotransmitter signaling and tumor growth in children.
dlvr.it
Reposted by Corina Anastasaki
Neuron
@cp-neuron.bsky.social
· Sep 1
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present during neurodevelopment, using aberrant glutamate receptor stimulation to activate PDGFRα/ERK via Src. This uncovers a molecular link between neurotransmitter signaling and tumor growth in children.
dlvr.it
Reposted by Corina Anastasaki
Reposted by Corina Anastasaki
Reposted by Corina Anastasaki
Gutmann Lab
@gutmannlab.bsky.social
· Nov 28
Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth
Nature Communications - With the emergence of immune checkpoint inhibitor therapies for cancer, the authors use single-cell sequencing to assess exhausted T cell content in human glioma samples and...
nam10.safelinks.protection.outlook.com
Reposted by Corina Anastasaki
Reposted by Corina Anastasaki