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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Jun 13

It was such a great visit ! Always happy to learn and share with colleagues and patients. I can't wait for the next edition!

The Brigant Lab @brigantlab.bsky.social · Jun 13

Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky

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Reposted by Benjamin Brigant, PhD

The Brigant Lab @brigantlab.bsky.social · Jun 11

Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky

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Reposted by Benjamin Brigant, PhD

The Brigant Lab @brigantlab.bsky.social · May 17

Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · May 13

Always amazed by the cells under a microscope 😍

The Brigant Lab @brigantlab.bsky.social · May 13

#InsideBrigantLab How do aging cells drive joint damage?🤔
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴

Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab

🌟 Inside Brigant Lab : The chondrocytes cells 🌟

Have you ever wondered how aging cells contribute to joint damage?
Let’s dive into the science together! 🧠💡

Meet the chondrocytes, the architects of cartilage health, maintaining its structure and function. But in osteoarthritis (OA), their balance is disrupted. These cells start contributing to cartilage breakdown, driving joint degeneration. As they age, chondrocytes lose their ability to repair cartilage and produce proteins that accelerate its destruction—worsening joint damage and fueling the progression of OA. Understanding their role is key to unlocking new treatments. 🧬🦴✨

Image: Chondrocyte cells in 2D culture

Want to know more?

Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our research and an exclusive preview of what’s next in our scientific journey. 🔍

#CellularBiology #chondrocyteresearch #osteoarthritis #science #research #ArthritisAwarenessMonth #MolecularMedicine#sciencecommunication#lablife #brigantlab #insidebrigantlab

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · May 6

Lots of exciting projects in our lab !

The Brigant Lab @brigantlab.bsky.social · May 6

👀 Curious about what happens at Brigant Lab?

Follow our new series: #InsideBrigantLab!

Explore our research, discoveries, and beyond. 🧬💡😃

#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab

🌟 Welcome to InsideBrigantLab! 🌟

In this series, we’ll take you behind the scenes of our lab’s journey to advance diagnostics and develop innovative treatments for rheumatologic diseases.🔬💊📖

Our first feature focuses on Osteoarthritis (OA), the most common form of arthritis—a condition that wears down joint cartilage over time. Think of cartilage as the cushion between your joints. In OA, that cushion wears thin, leading to pain and stiffness. OA affects millions worldwide and significantly reduces quality of life. 🦴♿

Did you know that by 2050, 1 in 3 people may be living with OA? Understanding its symptoms, prevalence, and the current limitations in treatments is crucial for driving innovative research. 💡

While prevention strategies exist, effective disease-modifying treatments remain a significant unmet need—and this is where our work comes in.
At BrigantLab, we’re diving deep into the molecular mechanisms of OA, with a special focus on the role of chondrocytes and connective tissues.🧬🩺

Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our work, the impact we strive to create, and an exclusive preview of what’s next in our scientific journey. Have questions or topics you’d like us to explore? Let us know! 😊

#osteoarthritis #osteoarthritisawareness #rheumaticdisease #chondrocyteresearch #molecularmedicine #research #sciencecommunication #BrigantLab #InsideBrigantLab

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · May 2

First official publication after the start of the brigant lab ! The first of a long series!
Thank you to all the authors and friends for this work.

The Brigant Lab @brigantlab.bsky.social · May 2

Proud to be part of this new study on uremic toxins & miR-223 in CKD anemia.
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009

#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab

🚨 Exciting Research Update! 🚨

We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉

We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬

Why is this important?

These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡

A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨

🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio]

📖 Stay tuned for more updates from BrigantLab ! 🚀

#ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab

Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Apr 25

Go to like the page if you want to follow our adventure !

The Brigant Lab @brigantlab.bsky.social · Apr 25

👋🔬 Behind BrigantLab: Meet co-founder Dr. Benjamin Brigant (NTNU)! 9+ yrs in molecular bio, from France to Norway. Focus: rare genetic conditions, osteoarthritis & more. Cross-country ski lover! ❄️ Follow our science journey! ➡️ [Linktree in bio]
#AcademicSky #MedSky #lablife #BehindBrigantLab

👋🔬 "Behind the BrigantLab" series - Meet the Minds Behind BrigantLab!

Today, let's spotlight Dr. Benjamin Brigant, researcher at NTNU in Trondheim, co-founder and a driving force of BrigantLab ! Currently based at the Norwegian University of Science and Technology (NTNU) in Trondheim, Benjamin brings over 9 years of expertise in molecular and cellular biology to the forefront of our research.

💡 His journey spanned studying studying microRNAs in France (UPJV), pioneering CRISPR-Cas13 RNA targeting in Canada (UoA, Alberta), and exploring CD5L in Norway (NTNU).

Now, at BrigantLab, Benjamin’s work bridges his diverse experiences in inflammation and cartilage biology. His focus includes osteoarthritis, joint disorders, and rare genetic conditions like MULIBREY nanism and Ehlers-Danlos Syndrome, with a special emphasis on joint, cartilage, and inflammation abnormalities. 🧬💪

🌍 His passion for discovery is matched only by his enthusiasm for connecting ideas across disciplines—whether in the lab or at collaborative works.

✨ Fun fact: When he’s not in the lab, you might find him hitting the snow ❄️ and cross-country skiing 🎿 during the winter months!

👉 Follow us for more behind-the-scenes moments, research updates, and a peek into life at BrigantLab!

🦓 Don’t forget, you can support our latest project: https://gofund.me/15cbe96b

🔗 Visit our Linktree in bio to learn more!

#BehindBrigantLab #meettheteam #brigantlab #science #research #supportscience #lablife #skiingscientists

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Apr 9

@ohtwist.bsky.social Maybe you know someone who would be interested in this project! 😊
We're planning to explore new potential EDS biomarkers while also investigating specific mechanisms involved in mast cell activation disorders.
Feel free to reach out or share!

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Apr 4

After a few months of silence, I’m thrilled to share this promising project!

To bring it to life, we need your support!

Share it as much as possible and join us in making this project a reality!

Help us here: gofund.me/15cbe96b

#AcademicSky

The Brigant Lab @brigantlab.bsky.social · Apr 4

Help us speed up EDS diagnosis! 🦓 Brigant Lab's biomarker research aims for faster, fairer answers. 💥

🔗 gofund.me/15cbe96b

Your support (donations, shares, kind words) means the world! Thank you! 💖✨
#EDS #ehlersdanlossyndrome #MedSky #Zebras #InsideBrigantLab

Hi everyone!

🌟 After a few weeks of silence, we're thrilled to finally share something close to our hearts — the latest project from Brigant Lab, and it needs your support.

🎉 We’re Launching: “Paving the Way of Hope” 🦓💫

Today, we’re proud to launch a groundbreaking research project dedicated to improving the diagnosis of Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders that affect millions around the world. 💔

For too many, the journey to a diagnosis takes 10+ years, filled with doubt, misdiagnoses, and invisible suffering. We believe people living with EDS deserve better. That’s why our team at the Brigant Lab (NTNU, Norway) is working to discover biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️

🧬 This project is fueled by real stories, real struggles — and the hope that science can bring change.

👉 We just launched our crowdfunding campaign and need YOUR help to make this possible. Whether you can donate, share, or simply spread awareness, you’re already part of this journey.

💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures.

🔗 https://gofund.me/15cbe96b

Thank you for being part of the journey. Your support means the world to us. 🤍

#Pavingthewayofhope#eds#ehlersdanlossyndrome#ehlersdanlossyndromeawareness#chronicillness#invisibledisability#edscommunity#raredisease#zebrastrong #genetics#medicalresearch#crowdfundingscience#supportresearch#supportscience#researchers#lablife #BrigantLab

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Jan 8

🎉 Happy New Year!
Wishing everyone a successful 2025! This year is special as we officially launch our lab!

Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!

#AcademicSky #EDS #Health

The Brigant Lab @brigantlab.bsky.social · Jan 6

Happy 2025! 🎉 Lab Launch!
Stay tuned for our journey! 🧪✨🚀

#PhDSky #AcademicSky #MedSky #NewBeginnings #Science #Innovation

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 31

🎉🧪 As 2024 comes to a close, let's play together and share a published paper from 2024 that inspired you or made a significant impact in your field.🌟

Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 29

I was very lucky to see beautiful Cloud iridescence this morning all over the city!
#Cloud #Nature #Norway

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 24

🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2025 brimming with success and grants and publications ! 🧾✨
#lab&fun #academicsky #medsky

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 21

🌟 Happy Winter Solstice and Happy Holidays! 🌟 In Trondheim, today, the sunrise was at 10:01 AM and the sunset at 2:31 PM. It's comforting to know that the days will soon start getting longer. (and don't forget your D-vitamin !) ❄️✨
#AcadelicSky

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 17

I always love seeing surprising results! This is a very good discovery but these results raise a lot of questions, but it is definitely a new area of research in acute inflammatory response!

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Reposted by Benjamin Brigant, PhD

OhTWIST @ohtwist.bsky.social · Dec 15

Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome 2017:

www.ncbi.nlm.nih.gov/pmc/articles...

#EDS #LDS #Mafran #CTD #meded #FOAMed #medicine #doctors #genetics #MedSky

Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome

Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blo...

www.ncbi.nlm.nih.gov

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 17

This would be helpful to screen any EV in any cell type. They succeeded in different cell line. However , I don't know how important it is in the secretion of EVs during mast cell activation in comparison to secretion of cytokines and other free molecules.

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 11

My all-time favorite from #zczpellascience will always be #CRISPR #Cas9 – the melody of science that keeps changing the world!

CRISPR-Cas9 ("Mr. Sandman" Parody) | A Capella Science

YouTube video by acapellascience

youtu.be

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 11

Do you want a nice Christmas song in your lab ?
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun

❄️ single cells, single cells! ❄️ #acapella #science #christmas

YouTube video by acapellascience

youtube.com

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 11

No it is online, so you can do it from anywhere. I am not working in the US and did it. It is harder to find a suitable time for everyone with the time difference that's it. 😊

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 10

🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩‍🔬

The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨

#PhDSky #AcademicSky #MedSky

SKYPE A SCIENTIST

Skype a Scientist matches your classroom, scout troop, or library with scientists for Q&A sessions for free!

www.skypeascientist.com

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Dec 7

Use the #lab&fun and #ScienceJokes to develop the feed:

bsky.app/profile/did:...

PHD Comics @phdcomics.com · Dec 7

How long it takes...

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Nov 25

#AcademicSky

CRISPRGuru @crisprguru.bsky.social · Nov 24

In my opinion, this paper is A MUST READ for anyone who writes grant proposals.

I am sure you will agree that 'reading this entire paper was totally worth your time.'

Itai Yanai @itaiyanai.bsky.social · Nov 24

How to write a grant?
1. The application is for the reviewer, not you, the applicant.
2. Communicate in stories.
3. Make your story cohesive—leave no puzzling gaps.
4. Make your story resonate to keep the reviewer reading.
5. Accept chance and noise in peer-review.
www.pnas.org/doi/epub/10....

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Nov 20

Congratulations to the team for this work! An innovative way to use #CRISPR 🧬 ! This study uses CRISPR-gRNA to barcode small extracellular vesicles, enabling subpopulation-specific analysis of their biogenesis and release. A groundbreaking tool for studying sEV heterogeneity!
#MolecularBiology

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators - Nature Communications

The release processes of small extracellular vesicles (sEVs) remain poorly understood despite their importance. Here, Kunitake et al. present a screening platform called CIBER screening that enables e...

www.nature.com

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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Nov 16

#AcademicSky

You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed !

(And you can join the feed here:
bsky.app/profile/did:... )

Justin W. Andrushko @jandrushko.bsky.social · Nov 16

#AcademicSky #UKAcademics

This has always been a funny one to me I think is worth sharing 😆

PhD stress progress #AcademicSky #UKAcademics research

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