Benjamin Brigant, PhD
@crisprandbeyond.bsky.social
Researcher 🔬 | CRISPR | Unraveling the link between inflammation and pathologies, Focus on Ehlers-Danlos syndrome and osteoarthritis
PhD in France, Post doc in Norway and Canada
PhD in France, Post doc in Norway and Canada
It was such a great visit ! Always happy to learn and share with colleagues and patients. I can't wait for the next edition!
Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky
June 13, 2025 at 10:56 AM
It was such a great visit ! Always happy to learn and share with colleagues and patients. I can't wait for the next edition!
Reposted by Benjamin Brigant, PhD
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
June 11, 2025 at 7:04 PM
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
Reposted by Benjamin Brigant, PhD
Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨
May 17, 2025 at 10:36 AM
Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨
Always amazed by the cells under a microscope 😍
#InsideBrigantLab How do aging cells drive joint damage?🤔
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴
Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴
Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab
May 13, 2025 at 8:53 AM
Always amazed by the cells under a microscope 😍
Lots of exciting projects in our lab !
👀 Curious about what happens at Brigant Lab?
Follow our new series: #InsideBrigantLab!
Explore our research, discoveries, and beyond. 🧬💡😃
#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab
Follow our new series: #InsideBrigantLab!
Explore our research, discoveries, and beyond. 🧬💡😃
#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab
May 6, 2025 at 5:51 PM
Lots of exciting projects in our lab !
First official publication after the start of the brigant lab ! The first of a long series!
Thank you to all the authors and friends for this work.
Thank you to all the authors and friends for this work.
Proud to be part of this new study on uremic toxins & miR-223 in CKD anemia.
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009
#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009
#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab
![🚨 Exciting Research Update! 🚨
We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉
We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬
Why is this important?
These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡
A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨
🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio]
📖 Stay tuned for more updates from BrigantLab ! 🚀
#ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:uswgysbcxwxhseeof5gcws4m/bafkreieti3s22avgebtftt3nmezne2ag7q4xb4jlvpznsqkt4kvkohyzju@jpeg)
May 2, 2025 at 7:14 PM
First official publication after the start of the brigant lab ! The first of a long series!
Thank you to all the authors and friends for this work.
Thank you to all the authors and friends for this work.
Go to like the page if you want to follow our adventure !
👋🔬 Behind BrigantLab: Meet co-founder Dr. Benjamin Brigant (NTNU)! 9+ yrs in molecular bio, from France to Norway. Focus: rare genetic conditions, osteoarthritis & more. Cross-country ski lover! ❄️ Follow our science journey! ➡️ [Linktree in bio]
#AcademicSky #MedSky #lablife #BehindBrigantLab
#AcademicSky #MedSky #lablife #BehindBrigantLab
April 25, 2025 at 5:27 PM
Go to like the page if you want to follow our adventure !
After a few months of silence, I’m thrilled to share this promising project!
To bring it to life, we need your support!
Share it as much as possible and join us in making this project a reality!
Help us here: gofund.me/15cbe96b
#AcademicSky
To bring it to life, we need your support!
Share it as much as possible and join us in making this project a reality!
Help us here: gofund.me/15cbe96b
#AcademicSky
Help us speed up EDS diagnosis! 🦓 Brigant Lab's biomarker research aims for faster, fairer answers. 💥
🔗 gofund.me/15cbe96b
Your support (donations, shares, kind words) means the world! Thank you! 💖✨
#EDS #ehlersdanlossyndrome #MedSky #Zebras #InsideBrigantLab
🔗 gofund.me/15cbe96b
Your support (donations, shares, kind words) means the world! Thank you! 💖✨
#EDS #ehlersdanlossyndrome #MedSky #Zebras #InsideBrigantLab
April 4, 2025 at 1:08 PM
After a few months of silence, I’m thrilled to share this promising project!
To bring it to life, we need your support!
Share it as much as possible and join us in making this project a reality!
Help us here: gofund.me/15cbe96b
#AcademicSky
To bring it to life, we need your support!
Share it as much as possible and join us in making this project a reality!
Help us here: gofund.me/15cbe96b
#AcademicSky
🎉 Happy New Year!
Wishing everyone a successful 2025! This year is special as we officially launch our lab!
Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!
#AcademicSky #EDS #Health
Wishing everyone a successful 2025! This year is special as we officially launch our lab!
Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!
#AcademicSky #EDS #Health
Happy 2025! 🎉 Lab Launch!
Stay tuned for our journey! 🧪✨🚀
#PhDSky #AcademicSky #MedSky #NewBeginnings #Science #Innovation
Stay tuned for our journey! 🧪✨🚀
#PhDSky #AcademicSky #MedSky #NewBeginnings #Science #Innovation
January 8, 2025 at 10:01 AM
🎉 Happy New Year!
Wishing everyone a successful 2025! This year is special as we officially launch our lab!
Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!
#AcademicSky #EDS #Health
Wishing everyone a successful 2025! This year is special as we officially launch our lab!
Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!
#AcademicSky #EDS #Health
🎉🧪 As 2024 comes to a close, let's play together and share a published paper from 2024 that inspired you or made a significant impact in your field.🌟
Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky
Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky
December 31, 2024 at 11:59 AM
🎉🧪 As 2024 comes to a close, let's play together and share a published paper from 2024 that inspired you or made a significant impact in your field.🌟
Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky
Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky
🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2025 brimming with success and grants and publications ! 🧾✨
#lab&fun #academicsky #medsky
#lab&fun #academicsky #medsky
December 24, 2024 at 7:06 PM
🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2025 brimming with success and grants and publications ! 🧾✨
#lab&fun #academicsky #medsky
#lab&fun #academicsky #medsky
🌟 Happy Winter Solstice and Happy Holidays! 🌟 In Trondheim, today, the sunrise was at 10:01 AM and the sunset at 2:31 PM. It's comforting to know that the days will soon start getting longer. (and don't forget your D-vitamin !) ❄️✨
#AcadelicSky
#AcadelicSky
December 21, 2024 at 10:15 PM
🌟 Happy Winter Solstice and Happy Holidays! 🌟 In Trondheim, today, the sunrise was at 10:01 AM and the sunset at 2:31 PM. It's comforting to know that the days will soon start getting longer. (and don't forget your D-vitamin !) ❄️✨
#AcadelicSky
#AcadelicSky
Reposted by Benjamin Brigant, PhD
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome 2017:
www.ncbi.nlm.nih.gov/pmc/articles...
#EDS #LDS #Mafran #CTD #meded #FOAMed #medicine #doctors #genetics #MedSky
www.ncbi.nlm.nih.gov/pmc/articles...
#EDS #LDS #Mafran #CTD #meded #FOAMed #medicine #doctors #genetics #MedSky
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blo...
www.ncbi.nlm.nih.gov
December 15, 2024 at 10:51 PM
Do you want a nice Christmas song in your lab ?
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun
❄️ single cells, single cells! ❄️ #acapella #science #christmas
YouTube video by acapellascience
youtube.com
December 11, 2024 at 7:21 PM
Do you want a nice Christmas song in your lab ?
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun
🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩🔬
The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨
#PhDSky #AcademicSky #MedSky
The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨
#PhDSky #AcademicSky #MedSky
SKYPE A SCIENTIST
Skype a Scientist matches your classroom, scout troop, or library with scientists for Q&A sessions for free!
www.skypeascientist.com
December 10, 2024 at 10:27 AM
🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩🔬
The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨
#PhDSky #AcademicSky #MedSky
The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨
#PhDSky #AcademicSky #MedSky
December 7, 2024 at 6:08 PM
In my opinion, this paper is A MUST READ for anyone who writes grant proposals.
I am sure you will agree that 'reading this entire paper was totally worth your time.'
I am sure you will agree that 'reading this entire paper was totally worth your time.'
How to write a grant?
1. The application is for the reviewer, not you, the applicant.
2. Communicate in stories.
3. Make your story cohesive—leave no puzzling gaps.
4. Make your story resonate to keep the reviewer reading.
5. Accept chance and noise in peer-review.
www.pnas.org/doi/epub/10....
November 25, 2024 at 5:12 AM
Congratulations to the team for this work! An innovative way to use #CRISPR 🧬 ! This study uses CRISPR-gRNA to barcode small extracellular vesicles, enabling subpopulation-specific analysis of their biogenesis and release. A groundbreaking tool for studying sEV heterogeneity!
#MolecularBiology
#MolecularBiology
Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators - Nature Communications
The release processes of small extracellular vesicles (sEVs) remain poorly understood despite their importance. Here, Kunitake et al. present a screening platform called CIBER screening that enables e...
www.nature.com
November 20, 2024 at 9:43 PM
Congratulations to the team for this work! An innovative way to use #CRISPR 🧬 ! This study uses CRISPR-gRNA to barcode small extracellular vesicles, enabling subpopulation-specific analysis of their biogenesis and release. A groundbreaking tool for studying sEV heterogeneity!
#MolecularBiology
#MolecularBiology
#AcademicSky
You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed !
(And you can join the feed here:
bsky.app/profile/did:... )
You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed !
(And you can join the feed here:
bsky.app/profile/did:... )
November 16, 2024 at 11:23 AM
#AcademicSky
You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed !
(And you can join the feed here:
bsky.app/profile/did:... )
You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed !
(And you can join the feed here:
bsky.app/profile/did:... )
#AcademicSky, #molecularbiology #CRISPR
Let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about.
1) development of nanoparticles to treat arthritis
2) fundraising for academic research
Let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about.
1) development of nanoparticles to treat arthritis
2) fundraising for academic research
Bluesky academics, let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about.
Here's mine:
- Whether we can have statehood without inhabitable land.
- The legal-philosophical symbolism in Wagner's Ring.
Here's mine:
- Whether we can have statehood without inhabitable land.
- The legal-philosophical symbolism in Wagner's Ring.
November 14, 2024 at 8:14 PM
#AcademicSky, #molecularbiology #CRISPR
Let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about.
1) development of nanoparticles to treat arthritis
2) fundraising for academic research
Let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about.
1) development of nanoparticles to treat arthritis
2) fundraising for academic research
With so many new people joining, here’s a great resource for both new and seasoned science fans! @mIT just released a curated list of must-follow accounts to keep up with the latest research and discoveries. Check it out!
#academicsky #molecularbiology
#academicsky #molecularbiology
Make sure you're keeping up with all of MIT Technology Review's reporters and editors here on Bluesky! We've made it easy for you to follow them all with this handy starter pack: go.bsky.app/EFjWHts
November 13, 2024 at 5:49 AM
With so many new people joining, here’s a great resource for both new and seasoned science fans! @mIT just released a curated list of must-follow accounts to keep up with the latest research and discoveries. Check it out!
#academicsky #molecularbiology
#academicsky #molecularbiology
In October, I had the chance to travel to Brussels to attend the Osteoarthritis Foundation Gala at the beautiful Chalet Robinson. An unforgettable experience for us as young scientists! (Thread) #academicsky #OsteoArthritis
November 12, 2024 at 6:18 PM
In October, I had the chance to travel to Brussels to attend the Osteoarthritis Foundation Gala at the beautiful Chalet Robinson. An unforgettable experience for us as young scientists! (Thread) #academicsky #OsteoArthritis
Very exciting to see the first clinical trial with CRISPR/Cas13 in action! Targeting RNA offers distinct advantages over DNA-targeting approaches and I’m convinced Cas13 holds great promise for the future of gene editing therapies. #CRISPR #molecularbiology
News: FDA Clears First CRISPR-Cas13 RNA-Editing Trial for Macular Degeneration - CRISPR Medicine
The FDA has cleared HuidaGene Therapeutics' investigational new drug application for HG202, the first CRISPR-Cas13 RNA-editing therapy to enter clinical trials. HG202 is designed to treat neovascular age-related macular degeneration, which is a leading cause of blindness in people over the age of 60.
crisprmedicinenews.com
November 9, 2024 at 6:01 PM
Very exciting to see the first clinical trial with CRISPR/Cas13 in action! Targeting RNA offers distinct advantages over DNA-targeting approaches and I’m convinced Cas13 holds great promise for the future of gene editing therapies. #CRISPR #molecularbiology
CRISPR News! 🧬
CRISPR isn’t just about DNA “scissors”! Scientists at Rockefeller and MSKCC found that CRISPR-Cas10, a different type, works like a molecular fumigator. It floods infected bacteria with toxic molecules to stop viruses in their tracks.
#CRISPR #Genetics #Microbiology
CRISPR isn’t just about DNA “scissors”! Scientists at Rockefeller and MSKCC found that CRISPR-Cas10, a different type, works like a molecular fumigator. It floods infected bacteria with toxic molecules to stop viruses in their tracks.
#CRISPR #Genetics #Microbiology
A new chemistry for CRISPR - News
It acts as a sort of molecular fumigator to battle phages and plasmids.
www.rockefeller.edu
October 29, 2024 at 10:19 AM
CRISPR News! 🧬
CRISPR isn’t just about DNA “scissors”! Scientists at Rockefeller and MSKCC found that CRISPR-Cas10, a different type, works like a molecular fumigator. It floods infected bacteria with toxic molecules to stop viruses in their tracks.
#CRISPR #Genetics #Microbiology
CRISPR isn’t just about DNA “scissors”! Scientists at Rockefeller and MSKCC found that CRISPR-Cas10, a different type, works like a molecular fumigator. It floods infected bacteria with toxic molecules to stop viruses in their tracks.
#CRISPR #Genetics #Microbiology