Daan van der Vliet
@daanvandervliet.bsky.social
PhD candidate in Chemical Neuroscience at Leiden University | Lipid metabolism | Chemical Biology | Neuroinflammation | Big fan of cats
https://orcid.org/0000-0001-7317-9679
https://orcid.org/0000-0001-7317-9679
Reposted by Daan van der Vliet
Spatially resolved mapping of monoacylglycerol lipase activity in the brain https://www.biorxiv.org/content/10.1101/2025.07.08.663730v1
July 12, 2025 at 3:16 PM
Spatially resolved mapping of monoacylglycerol lipase activity in the brain https://www.biorxiv.org/content/10.1101/2025.07.08.663730v1
Happy to share our new preprint! We analyzed lipid metabolism in a unique cohort of controls, AD patients, and individuals resilient to AD. We found reduced lipid droplets in resilience compared to AD. Interesting finding as more literature converges on an important role for lipid droplets in AD!
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer’s disease
Introduction While it has become clear that alterations in lipid metabolism are associated with AD, it is unclear how they contribute to both cognitive decline and the pathophysiology of AD.
Methods ...
www.biorxiv.org
May 26, 2025 at 9:19 AM
Happy to share our new preprint! We analyzed lipid metabolism in a unique cohort of controls, AD patients, and individuals resilient to AD. We found reduced lipid droplets in resilience compared to AD. Interesting finding as more literature converges on an important role for lipid droplets in AD!
Reposted by Daan van der Vliet
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease https://www.biorxiv.org/content/10.1101/2025.05.08.652735v1
May 14, 2025 at 12:15 PM
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease https://www.biorxiv.org/content/10.1101/2025.05.08.652735v1
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses -- very cool resource snRNAseq study of MS lesions highlighting patient variability in glial cell states
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in white matter glia, suggesting different pathological processes and future personalized therapies.
www.cell.com
December 21, 2024 at 12:11 PM
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses -- very cool resource snRNAseq study of MS lesions highlighting patient variability in glial cell states
If you're interested in microglial states and lipids in MS: Check out our recent preprint on foamy microglia! We show that foamy microglia in MS lesions determine the molecular profile of lesions and these might steer towards chronic lesion expansion. #lipidtime #MS #microglia
Foamy microglia link oxylipins to disease progression in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease characterized by expanding demyelinating lesions, leading to severe and irreversible disability. The mechanisms driving lesion expansion, however...
www.biorxiv.org
November 28, 2024 at 10:27 AM
If you're interested in microglial states and lipids in MS: Check out our recent preprint on foamy microglia! We show that foamy microglia in MS lesions determine the molecular profile of lesions and these might steer towards chronic lesion expansion. #lipidtime #MS #microglia
Very cool to see the energy of the scientific community to make Bluesky a place for fruitful and positive interaction! Also hoping to see a continuation of #MicroscopyMonday and #FluorescenceFriday here!
November 18, 2024 at 7:39 PM
Very cool to see the energy of the scientific community to make Bluesky a place for fruitful and positive interaction! Also hoping to see a continuation of #MicroscopyMonday and #FluorescenceFriday here!