Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
P2 #weightloss data over 13 weeks for VK2735 the once weekly GIPR-GLP1R medicine in adults with #obesity or overweight and ≥ 1 weight-related comorbidity onlinelibrary.wiley.com/doi/10.1002/...
January 10, 2026 at 12:29 PM
P2 #weightloss data over 13 weeks for VK2735 the once weekly GIPR-GLP1R medicine in adults with #obesity or overweight and ≥ 1 weight-related comorbidity onlinelibrary.wiley.com/doi/10.1002/...
Identification of an intestinotrophic YAP-1 activating fungus-derived peptide expands the therapeutic potential of the mycobiome, positioning it as a source of biologics for inflammatory and iatrogenic gut disorders. www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 10, 2026 at 12:19 PM
Identification of an intestinotrophic YAP-1 activating fungus-derived peptide expands the therapeutic potential of the mycobiome, positioning it as a source of biologics for inflammatory and iatrogenic gut disorders. www.nature.com/articles/s41...
It turns out that high-intensity interval training whether once or 3x weekly over 16 weeks reduces fat mass in adults with overweight and central #obesity #exercise www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 10, 2026 at 12:11 PM
It turns out that high-intensity interval training whether once or 3x weekly over 16 weeks reduces fat mass in adults with overweight and central #obesity #exercise www.nature.com/articles/s41...
Loss of TRPM7 kinase function impairs mTOR signaling, leading to reduced α-cell proliferation and glucagon secretion @MolMetab www.sciencedirect.com/science/arti...
TRPM7 Kinase Regulates α-Cell Proliferation and Glucagon Production in Mice
Glucagon is essential for maintaining glucose homeostasis, yet the molecular mechanisms governing α-cell function remain incompletely understood. Tran…
www.sciencedirect.com
January 10, 2026 at 2:28 AM
Loss of TRPM7 kinase function impairs mTOR signaling, leading to reduced α-cell proliferation and glucagon secretion @MolMetab www.sciencedirect.com/science/arti...
α-cells use glucagon-mediated and/or GLP-1–mediated paracrine signaling to fine-tune β-cell #insulin secretion via microtubule remodeling diabetesjournals.org/diabetes/art...
Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets
The microtubule network in β-cells attenuates insulin secretion by pulling insulin secretory granules away from the plasma membrane. Thus, high-glucose–ind
diabetesjournals.org
January 9, 2026 at 10:09 PM
α-cells use glucagon-mediated and/or GLP-1–mediated paracrine signaling to fine-tune β-cell #insulin secretion via microtubule remodeling diabetesjournals.org/diabetes/art...
Preclinical experimentation supports that ciliopathy-associated #obesity particularly Alström syndrome, may be mitigated by ACBP neutralization. www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 9, 2026 at 12:00 PM
Preclinical experimentation supports that ciliopathy-associated #obesity particularly Alström syndrome, may be mitigated by ACBP neutralization. www.nature.com/articles/s41...
Beyond the gym, testosterone and systemic metabolism www.nature.com/articles/s42...
Client Challenge
www.nature.com
January 9, 2026 at 11:55 AM
Beyond the gym, testosterone and systemic metabolism www.nature.com/articles/s42...
The TOGETHER PsA trial, tirzepatide+ixekizumab for adults with active psoriatic arthritis and obesity or overweight. New benefits (ACR50) for patients across clinically important endpoints #psoriasis #arthritis investor.lilly.com/news-release...
investor.lilly.com
January 8, 2026 at 7:11 PM
The TOGETHER PsA trial, tirzepatide+ixekizumab for adults with active psoriatic arthritis and obesity or overweight. New benefits (ACR50) for patients across clinically important endpoints #psoriasis #arthritis investor.lilly.com/news-release...
Congratulations to Professor Roman Hovorka, the 2025 Manpei Suzuki Prizze in #Diabetes Honoree www.mrl.ims.cam.ac.uk/news/double-... @easdnews.bsky.social
January 8, 2026 at 2:56 PM
Congratulations to Professor Roman Hovorka, the 2025 Manpei Suzuki Prizze in #Diabetes Honoree www.mrl.ims.cam.ac.uk/news/double-... @easdnews.bsky.social
Here the authors propose that the adipose–gut axis, via ⬆️AFABP secretion in obesity binding to plasma transferrin, leading to iron accumulation in and impaired function of ISCs, is a therapeutic target for #obesity-associated intestinal disorders www.nature.com/articles/s42...
Obesity impairs gut repair via AFABP-mediated iron overload in intestinal stem cells - Nature Metabolism
Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.
www.nature.com
January 8, 2026 at 1:49 PM
Here the authors propose that the adipose–gut axis, via ⬆️AFABP secretion in obesity binding to plasma transferrin, leading to iron accumulation in and impaired function of ISCs, is a therapeutic target for #obesity-associated intestinal disorders www.nature.com/articles/s42...
Stopping effective medications to treat hundreds of serious chronic diseases results in resurgence of the disease. #Obesity is no different, yet why are PPL surprised? Stopping obesity drugs means people regain weight and lose heart health benefits www.statnews.com/2026/01/07/w...
Stopping obesity drugs means people regain weight and lose heart health benefits
Why the weight, and heart risks, return after stopping GLP-1 drugs.
www.statnews.com
January 8, 2026 at 1:42 PM
Stopping effective medications to treat hundreds of serious chronic diseases results in resurgence of the disease. #Obesity is no different, yet why are PPL surprised? Stopping obesity drugs means people regain weight and lose heart health benefits www.statnews.com/2026/01/07/w...
A new look at circulating microRNAs in cystic fibrosis-related #diabetes link.springer.com/article/10.1... @diabetologiajnl.bsky.social
Dynamic changes in circulating microRNAs during oral glucose tolerance testing support their potential as diagnostic and monitoring biomarkers in cystic fibrosis-related diabetes - Diabetologia
Aims/hypothesis MicroRNAs are potential predictors and mediators of metabolic disease. Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in cystic fibrosis (CF). Here we aimed to ...
link.springer.com
January 8, 2026 at 1:23 PM
A new look at circulating microRNAs in cystic fibrosis-related #diabetes link.springer.com/article/10.1... @diabetologiajnl.bsky.social
After 6 weeks of Rx patients with ACSs, low-dose IL-2 safely increases Tregcell levels and reduces arterial inflammation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial - Nature Medicine
In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of ...
www.nature.com
January 8, 2026 at 11:25 AM
After 6 weeks of Rx patients with ACSs, low-dose IL-2 safely increases Tregcell levels and reduces arterial inflammation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Here authors reveal proteins causally implicated in the pathogenesis of #T2D which may be leveraged for personalized medicine tailored to individuals of African ancestry. www.nature.com/articles/s41...
Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis - Nature Genetics
This study uses a high-dimensional proteomics panel to explore protein-level genetic associations with type 2 diabetes in a Ugandan cohort.
www.nature.com
January 8, 2026 at 11:20 AM
Here authors reveal proteins causally implicated in the pathogenesis of #T2D which may be leveraged for personalized medicine tailored to individuals of African ancestry. www.nature.com/articles/s41...
Always appreciate the should out and direction DS. For all my fashionista friends, lets start with the Canadian Tuxedo eh? elvdenim.com/blogs/storie...
January 8, 2026 at 12:56 AM
Always appreciate the should out and direction DS. For all my fashionista friends, lets start with the Canadian Tuxedo eh? elvdenim.com/blogs/storie...
The latest look at NAION and use of GLP-1 medicines; one additional case per approximately 2,700 treated patients diabetesjournals.org/care/article...
January 7, 2026 at 11:21 PM
The latest look at NAION and use of GLP-1 medicines; one additional case per approximately 2,700 treated patients diabetesjournals.org/care/article...
Supply, demand, pricing and outcomes for accessible GL:P-1 medicines in the USA. The impact on patients’ health and on overall health care spending for patients, payers and society while ensuring equitable access at fair prices for all Americans www.nejm.org/doi/full/10....
Insurance Coverage and Pricing of Weight-Loss Drugs in the United States | NEJM
The Trump administration’s agreements regarding glucagon-like peptide 1 receptor agonists
could reduce prices and improve access for some patients — and lead to substantial
additional spending.
www.nejm.org
January 7, 2026 at 10:40 PM
Supply, demand, pricing and outcomes for accessible GL:P-1 medicines in the USA. The impact on patients’ health and on overall health care spending for patients, payers and society while ensuring equitable access at fair prices for all Americans www.nejm.org/doi/full/10....
Studies of #inflammation related signals from cord blood at birth reveals a protein subset that predicts #T1D with high accuracy (AUC = 0.89 ± 0.02), independently of HLA genetic risk www.nature.com/articles/s41...
January 7, 2026 at 10:48 AM
Studies of #inflammation related signals from cord blood at birth reveals a protein subset that predicts #T1D with high accuracy (AUC = 0.89 ± 0.02), independently of HLA genetic risk www.nature.com/articles/s41...
Studies in mice lead to the proposal that Sirt6 activation or galectin-3 inhibition in macrophages may represent a therapeutic approach for #obesity associated adipose fibroinflammation and #insulin resistance. www.nature.com/articles/s41...
Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity through galectin-3 signaling - Nature Communications
Mast cells play a key role in obesity and insulin resistance through incompletely understood mechanisms. Here the authors report that loss of sirtuin 6 in mast cells promotes inflammation, fibrosis, a...
www.nature.com
January 6, 2026 at 11:04 AM
Studies in mice lead to the proposal that Sirt6 activation or galectin-3 inhibition in macrophages may represent a therapeutic approach for #obesity associated adipose fibroinflammation and #insulin resistance. www.nature.com/articles/s41...
How to best model glucotoxicity preclinically to study #diabetes www.nature.com/articles/s41...
Models of hyperglycaemia in diabetes mellitus and its complications - Nature Reviews Endocrinology
Many different models are used in research into diabetes mellitus, and each has strengths and limitations. In this Review, the authors explain several in vivo and in vitro models of hyperglycaemia and...
www.nature.com
January 6, 2026 at 10:59 AM
How to best model glucotoxicity preclinically to study #diabetes www.nature.com/articles/s41...
A new role for aged brain neuronal EVs as an important messenger in triggering bone-fat imbalance by transferring WDFY1 to bone www.nature.com/articles/s43...
Brain neuron-derived WDFY1 induces bone loss - Nature Aging
Chen et al. identify a brain-to-bone communication axis whereby extracellular vesicles from aged brain neurons transport WDFY1 protein to distal bone, driving bone-fat imbalance and promoting osteopor...
www.nature.com
January 5, 2026 at 11:00 AM
A new role for aged brain neuronal EVs as an important messenger in triggering bone-fat imbalance by transferring WDFY1 to bone www.nature.com/articles/s43...
A sex-specific role of GPR110 in #MASH by regulating hepatic oestrogen sensitivity www.nature.com/articles/s42...
Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling - Nature Metabolism
Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.
www.nature.com
January 5, 2026 at 10:58 AM
A sex-specific role of GPR110 in #MASH by regulating hepatic oestrogen sensitivity www.nature.com/articles/s42...
A sex-specific role of GPR110 in #MASH by regulating hepatic oestrogen sensitivity www.nature.com/articles/s42...
Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling - Nature Metabolism
Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.
www.nature.com
January 5, 2026 at 10:57 AM
A sex-specific role of GPR110 in #MASH by regulating hepatic oestrogen sensitivity www.nature.com/articles/s42...
Here the authors propose that emerging therapeutic strategies targeting autonomic function could offer promising opportunities to improve metabolic health www.nature.com/articles/s41...
The autonomic nervous system in the regulation of glucose and lipid metabolism - Nature Reviews Endocrinology
Chronic disturbances in autonomic regulation are increasingly recognized as contributors to metabolic diseases such as obesity and type 2 diabetes mellitus. In this Review, Wangler and colleagues disc...
www.nature.com
January 5, 2026 at 10:53 AM
Here the authors propose that emerging therapeutic strategies targeting autonomic function could offer promising opportunities to improve metabolic health www.nature.com/articles/s41...
Despite the heralded anti-inflammatory actions of statins, simvastatin had no effect on recurrences of acute or acute on chronic flares of #pancreatitis gut.bmj.com/content/earl...
Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial)
Background Recurrent acute pancreatitis (RAP) or acute-on-chronic flares in chronic pancreatitis (CP) have limited preventive options beyond addressing the underlying aetiology. Statins, due to their ...
gut.bmj.com
January 4, 2026 at 9:36 PM
Despite the heralded anti-inflammatory actions of statins, simvastatin had no effect on recurrences of acute or acute on chronic flares of #pancreatitis gut.bmj.com/content/earl...