@danielzkruse.bsky.social
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent manner
Thick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m...
www.biorxiv.org
November 27, 2025 at 2:53 PM
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Reposted
Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue
October 15, 2025 at 12:55 AM
Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue
I have had the fun (and challenging!) opportunity to explain some of my PhD research to a general audience.
Thanks to @apsphysiology.bsky.social!
Thanks to @apsphysiology.bsky.social!
Do fast cars burn more fuel? What if you swap out the engine? Your muscles work the same way—and in this case, the "engine" is a compound found in black pepper. @danielzkruse.bsky.social breaks it down on the #ISpyPhysiology blog: ow.ly/OQSQ50WATn9 🧪
August 6, 2025 at 7:17 PM
I have had the fun (and challenging!) opportunity to explain some of my PhD research to a general audience.
Thanks to @apsphysiology.bsky.social!
Thanks to @apsphysiology.bsky.social!
Reposted
New publication on #muscle stretch-shortening cycles. Elst et al. (2025). Eur J Physiol rdcu.be/elxuN
@neuromechahnics.bsky.social , @myoblue.bsky.social
@neuromechahnics.bsky.social , @myoblue.bsky.social
Consecutive SSCs increase the SSC effect in skinned rat muscle fibres
rdcu.be
May 11, 2025 at 7:30 AM
New publication on #muscle stretch-shortening cycles. Elst et al. (2025). Eur J Physiol rdcu.be/elxuN
@neuromechahnics.bsky.social , @myoblue.bsky.social
@neuromechahnics.bsky.social , @myoblue.bsky.social
Reposted
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 3:56 AM
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Reposted
@ambiotech.us on the lookout to hire some #MuscleScientists on a short-term, muscle small-angle X-ray diffraction project in June / July in NY. Must have work permission in USA and must have permeabilized fiber mechanics experience. X-ray experience not mandatory. Full travel plus pay. DM me!
April 18, 2025 at 2:44 PM
@ambiotech.us on the lookout to hire some #MuscleScientists on a short-term, muscle small-angle X-ray diffraction project in June / July in NY. Must have work permission in USA and must have permeabilized fiber mechanics experience. X-ray experience not mandatory. Full travel plus pay. DM me!
Just completed our first x-ray diffraction experiments at the PETRA III beamline in Hamburg - what an experience!
Intense night shifts with cool science on sarcomeric structures in skeletal muscle 💪🏼 Can’t wait to get into the results!
Thanks to @hesselanthony.bsky.social and @ambiotech.us
Intense night shifts with cool science on sarcomeric structures in skeletal muscle 💪🏼 Can’t wait to get into the results!
Thanks to @hesselanthony.bsky.social and @ambiotech.us
April 1, 2025 at 12:22 PM
Just completed our first x-ray diffraction experiments at the PETRA III beamline in Hamburg - what an experience!
Intense night shifts with cool science on sarcomeric structures in skeletal muscle 💪🏼 Can’t wait to get into the results!
Thanks to @hesselanthony.bsky.social and @ambiotech.us
Intense night shifts with cool science on sarcomeric structures in skeletal muscle 💪🏼 Can’t wait to get into the results!
Thanks to @hesselanthony.bsky.social and @ambiotech.us