David Steensma, MD
@davidsteensma.bsky.social
710 followers 65 following 78 posts
Hematologist-oncologist. Ajax Therapeutics CMO. Former Edward P. Evans Chair in #MDSsm at #DanaFarber; #HarvardMedicalSchool & #MayoClinic faculty, #Novartis global hematology head. @DavidSteensma
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davidsteensma.bsky.social
Thus far it seems to be a bit of a dud - watched for a while and only caught a single meteor. Maybe next year!
davidsteensma.bsky.social
You mean a good photo like the one you replied to using the same format as all your other replies, bot?
davidsteensma.bsky.social
It is unusual to see a barred owl on the ground, especially during the day. But this guy was doing some sort of maintenance in the dust alongside a remote hiking trail.

The owl was not injured. It flew away when it saw me, but not before posing for a nice photo.

#UnusualBirdBehavior
Barred owl with wings spread.
davidsteensma.bsky.social
Interesting! Did not know this… I wonder if there are other languages that use a similar term.
davidsteensma.bsky.social
"Blood poverty" was not a commonly used construct, but "Poverty of the blood" was used as a synonym for anemia in late 19th/early 20th century - especially from iron deficiency in young women, more frequently termed "chlorosis". See for example this 1892 paper, and a 1909 book by a McGill physician.
davidsteensma.bsky.social
Found this advertisement for "Blood Poverty" tonic - "Women naturally suffer more than men" - in a 1925 New Zealand newspaper.

While the first recorded use of 'cytopenia' was a 1906 paper per OED, it means 'cell poverty' - from the Greek πενίᾱ (peníā), poverty or lack.
@shematologist.medsky.social
davidsteensma.bsky.social
Wow - Is that your home freezer or the grocery store?!

February 1st is National Ice Cream For Breakfast Day - looks like you are well prepared 😊
davidsteensma.bsky.social
A small stream runs through the woods behind our house, and this morning “frost flowers” were on the surface.❄️ I’ve never seen them before!

They can form on thin ice on chilly, windless days when the air is much colder than the surface ice. Water vapor rising up from the surface quickly refreezes.
Frost flowers on thin ice.
davidsteensma.bsky.social
Blue skies and blue reflections in suburban Boston this morning ❄️
davidsteensma.bsky.social
The £100K treatment and £200K per year maintenance figures are for phlebotomy of 50 people rather than just one.

There are data that phlebotomy or plasmapheresis decreases PFAS levels.

Not saying this is the right approach, just that it is not the same as Bryan Johnson’s young blood nonsense.
davidsteensma.bsky.social
I was walking along a trail yesterday and noticed this Madagascar periwinkle (Catharanthus roseus) - the plant that “vinca alkaloid” anti-cancer drugs vincristine and vinblastine were isolated from back in 1961. They’re still used today, especially vincristine for acute lymphoid leukemia and NHL.
davidsteensma.bsky.social
Last night I imaged NGC891, the “Silver Sliver” galaxy, an edge-on spiral galaxy with a prominent dust lane about 30 million light-years away in the constellation Andromeda. It is sometimes called The Outer Limits galaxy because it appears in the credits of the TV show.
#astrophotography #galaxy
davidsteensma.bsky.social
My latest Mayo Clinic Proceedings stamp vignette on medical history is now online, about the "Dear Doctor" postcards of the 1950s & 1960s. Most were from Abbott Labs, touting sodium pentothal.

Author link with 50 days free access to the article"
authors.elsevier.com/a/1kN0a5qq8b...

#Deltiology
davidsteensma.bsky.social
Carolina wren fledgling having a bad hair day
davidsteensma.bsky.social
It’s really terrific to have this
davidsteensma.bsky.social
It’s interesting when we think about how much being iron deficient or anemic impairs function & health outcomes. But in 1900, the top causes of death in the US were pneumonia & influenza, TB, and GI infections a so human history is a long battle against the microbes and prob any little edge mattered
davidsteensma.bsky.social
Another factor may be iron-avid microorganisms that have been common causes of death historically (and still today in some places): E. coli, Yersinia, Salmonella, etc. Similar to hepcidin-driven iron sequestration, absolute iron deficiency can have a protective effect against growth of pathogens.
davidsteensma.bsky.social
How fun to be back @danafarber.bsky.social today (for an SIV).

The drive in is just as much of an adventure as it always was…

Nice to see friends & former colleagues in person -
davidsteensma.bsky.social
Eek! In a chair?! That would be like attempting a digital rectal exam without asking the patient to undress: uncomfortable & uninformative.

Alas, the physical exam is becoming a lost art - but hopefully since these were MPN clinical trialists they’d be better than average at spleen examination.
davidsteensma.bsky.social
Thought this was interesting: correlation between spleen length by palpation on physical exam in myelfibrosis versus spleen volume by centrally reviewed radiographic imaging, from a clinical trial described at #ASH24 by John Mascarenhas. There's a trend, but exam is not a super accurate measurement.
davidsteensma.bsky.social
The late-breaking abstract session in on-demand video form also makes great "background music" while packing up in your hotel room #ASH24
ash.hematology.org
The late-breaking abstracts — substantive, novel, and groundbreaking #hematology data that were not available by the general abstract submission deadline — are now being presented at #ASH24!

Read the ASH press releases: bit.ly/3D5vLE5 #HemeSky
davidsteensma.bsky.social
Starting the first ever @ash symposium for mid career hematologists #ASH24
davidsteensma.bsky.social
“The safety profile was generally manageable” is a statement utterly devoid of meaning #ASH24