Decoding Longevity
@decodinglongevity.bsky.social
🎙️ Decoding Longevity – Exploring the frontiers of aging science & longevity research.
🧬 Geroscience | Epigenetics | Healthspan
🎧 Listen https://open.spotify.com/episode/5PuTCbkQu3ptSQOXhQeL1P?si=JmG4ByFKQk-YFE7FXFgWaQ
🧬 Geroscience | Epigenetics | Healthspan
🎧 Listen https://open.spotify.com/episode/5PuTCbkQu3ptSQOXhQeL1P?si=JmG4ByFKQk-YFE7FXFgWaQ
What if breakthroughs in longevity don’t come from single discoveries, but from ecosystems built across science, capital, and community?
🎙️ Episode 19 of Decoding Longevity features Dr. Karl Pfleger on aging biotech, rejuvenation, and how progress actually happens.
🎙️ Episode 19 of Decoding Longevity features Dr. Karl Pfleger on aging biotech, rejuvenation, and how progress actually happens.
February 6, 2026 at 5:51 PM
What if breakthroughs in longevity don’t come from single discoveries, but from ecosystems built across science, capital, and community?
🎙️ Episode 19 of Decoding Longevity features Dr. Karl Pfleger on aging biotech, rejuvenation, and how progress actually happens.
🎙️ Episode 19 of Decoding Longevity features Dr. Karl Pfleger on aging biotech, rejuvenation, and how progress actually happens.
What if progress in longevity isn’t limited by ideas — but by how we measure them?
🎙️ Episode 19 of Decoding Longevity is now live.
A thoughtful conversation with Dr. Karl Pfleger on aging biotech, rejuvenation, biomarkers, and the ecosystem shaping longevity science.
🎙️ Episode 19 of Decoding Longevity is now live.
A thoughtful conversation with Dr. Karl Pfleger on aging biotech, rejuvenation, biomarkers, and the ecosystem shaping longevity science.
February 5, 2026 at 3:30 PM
What if progress in longevity isn’t limited by ideas — but by how we measure them?
🎙️ Episode 19 of Decoding Longevity is now live.
A thoughtful conversation with Dr. Karl Pfleger on aging biotech, rejuvenation, biomarkers, and the ecosystem shaping longevity science.
🎙️ Episode 19 of Decoding Longevity is now live.
A thoughtful conversation with Dr. Karl Pfleger on aging biotech, rejuvenation, biomarkers, and the ecosystem shaping longevity science.
We’re starting the new year of Decoding Longevity with Dr. Karl Pfleger.
From aging biotech and rejuvenation strategies to investment realities and ecosystem building, this episode explores what it takes to move longevity science forward.
🎧 Episode 19 releases tomorrow.
From aging biotech and rejuvenation strategies to investment realities and ecosystem building, this episode explores what it takes to move longevity science forward.
🎧 Episode 19 releases tomorrow.
February 3, 2026 at 4:17 PM
We’re starting the new year of Decoding Longevity with Dr. Karl Pfleger.
From aging biotech and rejuvenation strategies to investment realities and ecosystem building, this episode explores what it takes to move longevity science forward.
🎧 Episode 19 releases tomorrow.
From aging biotech and rejuvenation strategies to investment realities and ecosystem building, this episode explores what it takes to move longevity science forward.
🎧 Episode 19 releases tomorrow.
What if longevity science included something as old as humanity itself—rituals, rhythm, and shared energy?
In Ep18, Tina Woods introduces the idea of a “Longevity Rave,” highlighting how connection and movement support healthy aging.
In Ep18, Tina Woods introduces the idea of a “Longevity Rave,” highlighting how connection and movement support healthy aging.
December 11, 2025 at 6:46 PM
What if longevity science included something as old as humanity itself—rituals, rhythm, and shared energy?
In Ep18, Tina Woods introduces the idea of a “Longevity Rave,” highlighting how connection and movement support healthy aging.
In Ep18, Tina Woods introduces the idea of a “Longevity Rave,” highlighting how connection and movement support healthy aging.
Scientists now say loneliness may shorten lifespan more than smoking.
So what does that mean for the future of aging?
In Episode 18, we sit down with Tina Woods to explore how cities, social ties, community design, and exposome data shape health across a lifetime.
So what does that mean for the future of aging?
In Episode 18, we sit down with Tina Woods to explore how cities, social ties, community design, and exposome data shape health across a lifetime.
December 8, 2025 at 6:05 PM
Scientists now say loneliness may shorten lifespan more than smoking.
So what does that mean for the future of aging?
In Episode 18, we sit down with Tina Woods to explore how cities, social ties, community design, and exposome data shape health across a lifetime.
So what does that mean for the future of aging?
In Episode 18, we sit down with Tina Woods to explore how cities, social ties, community design, and exposome data shape health across a lifetime.
What if the key to healthy longevity isn’t only in our DNA — but in the cities and communities we live in? 🌍
In Episode 18, we talk with Tina Woods about the Exposome Revolution and how our environments shape how we age.
In Episode 18, we talk with Tina Woods about the Exposome Revolution and how our environments shape how we age.
December 4, 2025 at 6:04 PM
What if the key to healthy longevity isn’t only in our DNA — but in the cities and communities we live in? 🌍
In Episode 18, we talk with Tina Woods about the Exposome Revolution and how our environments shape how we age.
In Episode 18, we talk with Tina Woods about the Exposome Revolution and how our environments shape how we age.
“Longevity goes far beyond bioscience — it shapes policy, cities, design, and the way we live.” — Tina Woods
🎙️ Episode 18 is officially LIVE!
We dive deep into the exposome, longevity ecosystems, and how environments influence aging.
🎙️ Episode 18 is officially LIVE!
We dive deep into the exposome, longevity ecosystems, and how environments influence aging.
December 3, 2025 at 4:59 PM
“Longevity goes far beyond bioscience — it shapes policy, cities, design, and the way we live.” — Tina Woods
🎙️ Episode 18 is officially LIVE!
We dive deep into the exposome, longevity ecosystems, and how environments influence aging.
🎙️ Episode 18 is officially LIVE!
We dive deep into the exposome, longevity ecosystems, and how environments influence aging.
What if longevity isn’t shaped only by genetics — but by the city you live in, the air you breathe, the food you eat, the community around you?
Tomorrow we release our conversation with Tina Woods on the Human Exposome Project.
Episode drops TOMORROW. Don’t miss it
#Longevity #Exposome #HealthyAging
Tomorrow we release our conversation with Tina Woods on the Human Exposome Project.
Episode drops TOMORROW. Don’t miss it
#Longevity #Exposome #HealthyAging
December 2, 2025 at 5:27 PM
What if longevity isn’t shaped only by genetics — but by the city you live in, the air you breathe, the food you eat, the community around you?
Tomorrow we release our conversation with Tina Woods on the Human Exposome Project.
Episode drops TOMORROW. Don’t miss it
#Longevity #Exposome #HealthyAging
Tomorrow we release our conversation with Tina Woods on the Human Exposome Project.
Episode drops TOMORROW. Don’t miss it
#Longevity #Exposome #HealthyAging
Could stem cells unlock a new era of regenerative medicine? 🔬
In Episode 17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to discuss how tapping into our body’s earliest blueprint might one day reset aging itself.
In Episode 17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to discuss how tapping into our body’s earliest blueprint might one day reset aging itself.
November 10, 2025 at 5:36 PM
Could stem cells unlock a new era of regenerative medicine? 🔬
In Episode 17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to discuss how tapping into our body’s earliest blueprint might one day reset aging itself.
In Episode 17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to discuss how tapping into our body’s earliest blueprint might one day reset aging itself.
What if the key to longevity lies in the earliest stem cells — ones that can rejuvenate tissues without ethical barriers? 🌿
In Ep.17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to explore a new era of regenerative medicine.
In Ep.17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to explore a new era of regenerative medicine.
November 5, 2025 at 5:39 PM
What if the key to longevity lies in the earliest stem cells — ones that can rejuvenate tissues without ethical barriers? 🌿
In Ep.17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to explore a new era of regenerative medicine.
In Ep.17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to explore a new era of regenerative medicine.
Tomorrow’s episode dives into one of the most exciting frontiers in longevity — regenerative medicine. 🌱
Hosts Raghav Sehgal & Macsue Jacques chat with Yuta Lee (Accelerated Biosciences) about pioneering pluripotent stem cells that could redefine aging itself.
🎧 Episode 17 out tomorrow!
Hosts Raghav Sehgal & Macsue Jacques chat with Yuta Lee (Accelerated Biosciences) about pioneering pluripotent stem cells that could redefine aging itself.
🎧 Episode 17 out tomorrow!
November 4, 2025 at 7:33 PM
Tomorrow’s episode dives into one of the most exciting frontiers in longevity — regenerative medicine. 🌱
Hosts Raghav Sehgal & Macsue Jacques chat with Yuta Lee (Accelerated Biosciences) about pioneering pluripotent stem cells that could redefine aging itself.
🎧 Episode 17 out tomorrow!
Hosts Raghav Sehgal & Macsue Jacques chat with Yuta Lee (Accelerated Biosciences) about pioneering pluripotent stem cells that could redefine aging itself.
🎧 Episode 17 out tomorrow!
“You don’t need any of this oxidized cholesterol in your body.”
Dr. Matthew O’Connor explains how 7-ketocholesterol — a toxic, oxidized form — drives vascular aging.
🎧 Ep16 out now!
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
Dr. Matthew O’Connor explains how 7-ketocholesterol — a toxic, oxidized form — drives vascular aging.
🎧 Ep16 out now!
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
October 31, 2025 at 5:28 PM
“You don’t need any of this oxidized cholesterol in your body.”
Dr. Matthew O’Connor explains how 7-ketocholesterol — a toxic, oxidized form — drives vascular aging.
🎧 Ep16 out now!
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
Dr. Matthew O’Connor explains how 7-ketocholesterol — a toxic, oxidized form — drives vascular aging.
🎧 Ep16 out now!
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
We’ve been treating cholesterol for decades — but 7-ketocholesterol is far more toxic than we realized.
🎧 New Decoding Longevity episode out now!
Ep16: Targeting 7-Ketocholesterol in Atherosclerosis
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
🎧 New Decoding Longevity episode out now!
Ep16: Targeting 7-Ketocholesterol in Atherosclerosis
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
October 29, 2025 at 6:29 PM
We’ve been treating cholesterol for decades — but 7-ketocholesterol is far more toxic than we realized.
🎧 New Decoding Longevity episode out now!
Ep16: Targeting 7-Ketocholesterol in Atherosclerosis
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
🎧 New Decoding Longevity episode out now!
Ep16: Targeting 7-Ketocholesterol in Atherosclerosis
🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...
What if cardiovascular aging could be reversed? 🧬
In Episode 16 of Decoding Longevity, Matthew “Oki” O’Connor explains how targeting 7-ketocholesterol — a toxic oxidized cholesterol — might be the key to tackling atherosclerosis at its root. 🎙️
#Longevity #AgingResearch #CardiovascularHealth
In Episode 16 of Decoding Longevity, Matthew “Oki” O’Connor explains how targeting 7-ketocholesterol — a toxic oxidized cholesterol — might be the key to tackling atherosclerosis at its root. 🎙️
#Longevity #AgingResearch #CardiovascularHealth
October 27, 2025 at 8:54 PM
What if cardiovascular aging could be reversed? 🧬
In Episode 16 of Decoding Longevity, Matthew “Oki” O’Connor explains how targeting 7-ketocholesterol — a toxic oxidized cholesterol — might be the key to tackling atherosclerosis at its root. 🎙️
#Longevity #AgingResearch #CardiovascularHealth
In Episode 16 of Decoding Longevity, Matthew “Oki” O’Connor explains how targeting 7-ketocholesterol — a toxic oxidized cholesterol — might be the key to tackling atherosclerosis at its root. 🎙️
#Longevity #AgingResearch #CardiovascularHealth
🎙️ Episode 16 is out today!
What if cardiovascular aging could actually be reversed? 🫀
In today’s episode of Decoding Longevity, Matthew “Oki” O’Connor joins Raghav Sehgal and Macsue Jacques to explore how targeting 7-ketocholesterol could reshape heart health.
#Longevity
What if cardiovascular aging could actually be reversed? 🫀
In today’s episode of Decoding Longevity, Matthew “Oki” O’Connor joins Raghav Sehgal and Macsue Jacques to explore how targeting 7-ketocholesterol could reshape heart health.
#Longevity
October 22, 2025 at 5:12 PM
🎙️ Episode 16 is out today!
What if cardiovascular aging could actually be reversed? 🫀
In today’s episode of Decoding Longevity, Matthew “Oki” O’Connor joins Raghav Sehgal and Macsue Jacques to explore how targeting 7-ketocholesterol could reshape heart health.
#Longevity
What if cardiovascular aging could actually be reversed? 🫀
In today’s episode of Decoding Longevity, Matthew “Oki” O’Connor joins Raghav Sehgal and Macsue Jacques to explore how targeting 7-ketocholesterol could reshape heart health.
#Longevity
New episode drops tomorrow! 🎙️
Join Raghav Sehgal and Macsue Jacques in conversation with Matthew “Oki” O’Connor on how clearing 7-ketocholesterol — a toxic oxidized lipid — could reverse plaque buildup and change how we treat cardiovascular aging.
#Longevity #Atherosclerosis #HealthyAging
Join Raghav Sehgal and Macsue Jacques in conversation with Matthew “Oki” O’Connor on how clearing 7-ketocholesterol — a toxic oxidized lipid — could reverse plaque buildup and change how we treat cardiovascular aging.
#Longevity #Atherosclerosis #HealthyAging
October 21, 2025 at 5:54 PM
New episode drops tomorrow! 🎙️
Join Raghav Sehgal and Macsue Jacques in conversation with Matthew “Oki” O’Connor on how clearing 7-ketocholesterol — a toxic oxidized lipid — could reverse plaque buildup and change how we treat cardiovascular aging.
#Longevity #Atherosclerosis #HealthyAging
Join Raghav Sehgal and Macsue Jacques in conversation with Matthew “Oki” O’Connor on how clearing 7-ketocholesterol — a toxic oxidized lipid — could reverse plaque buildup and change how we treat cardiovascular aging.
#Longevity #Atherosclerosis #HealthyAging
“Longevity should be part of basic healthcare, not a privilege.” 🌍
In Episode 15 of Decoding Longevity, Jasmine Smith (Rejuve.AI) joins hosts Raghav Sehgal & Macsue Jacques to explore how AI and decentralized science make longevity more inclusive.
#Longevity #AI #DeSci #Healthspan
In Episode 15 of Decoding Longevity, Jasmine Smith (Rejuve.AI) joins hosts Raghav Sehgal & Macsue Jacques to explore how AI and decentralized science make longevity more inclusive.
#Longevity #AI #DeSci #Healthspan
October 17, 2025 at 7:20 PM
“Longevity should be part of basic healthcare, not a privilege.” 🌍
In Episode 15 of Decoding Longevity, Jasmine Smith (Rejuve.AI) joins hosts Raghav Sehgal & Macsue Jacques to explore how AI and decentralized science make longevity more inclusive.
#Longevity #AI #DeSci #Healthspan
In Episode 15 of Decoding Longevity, Jasmine Smith (Rejuve.AI) joins hosts Raghav Sehgal & Macsue Jacques to explore how AI and decentralized science make longevity more inclusive.
#Longevity #AI #DeSci #Healthspan
What if the future of science wasn’t locked in labs, but built on a global network of people sharing data and accelerating discoveries in real time? 🌍
That’s the vision of decentralized science (DeSci) — and it’s transforming how we study aging and longevity.
That’s the vision of decentralized science (DeSci) — and it’s transforming how we study aging and longevity.
October 10, 2025 at 8:06 PM
What if the future of science wasn’t locked in labs, but built on a global network of people sharing data and accelerating discoveries in real time? 🌍
That’s the vision of decentralized science (DeSci) — and it’s transforming how we study aging and longevity.
That’s the vision of decentralized science (DeSci) — and it’s transforming how we study aging and longevity.
“Decentralized science is about breaking down silos and creating a global network where everyone can contribute to longevity research.” 🌍🧬
In Decoding Longevity Ep.15, Raghav Sehgal & Macsue Jacques explore how Rejuve.AI’s vision of DeSci is changing the way we study aging.
In Decoding Longevity Ep.15, Raghav Sehgal & Macsue Jacques explore how Rejuve.AI’s vision of DeSci is changing the way we study aging.
October 8, 2025 at 6:11 PM
“Decentralized science is about breaking down silos and creating a global network where everyone can contribute to longevity research.” 🌍🧬
In Decoding Longevity Ep.15, Raghav Sehgal & Macsue Jacques explore how Rejuve.AI’s vision of DeSci is changing the way we study aging.
In Decoding Longevity Ep.15, Raghav Sehgal & Macsue Jacques explore how Rejuve.AI’s vision of DeSci is changing the way we study aging.
Beyond DNA: the future of aging research lies in multi-omics approaches. 🌍
In Ep.14 of Decoding Longevity, host Macsue Jacques and Prof. Brian Kennedy discuss how proteomics, lipidomics, and other biomarkers can provide a holistic view of aging.
#Longevity #HealthyAging #MultiOmics #BrianKennedy
In Ep.14 of Decoding Longevity, host Macsue Jacques and Prof. Brian Kennedy discuss how proteomics, lipidomics, and other biomarkers can provide a holistic view of aging.
#Longevity #HealthyAging #MultiOmics #BrianKennedy
October 6, 2025 at 6:19 PM
Beyond DNA: the future of aging research lies in multi-omics approaches. 🌍
In Ep.14 of Decoding Longevity, host Macsue Jacques and Prof. Brian Kennedy discuss how proteomics, lipidomics, and other biomarkers can provide a holistic view of aging.
#Longevity #HealthyAging #MultiOmics #BrianKennedy
In Ep.14 of Decoding Longevity, host Macsue Jacques and Prof. Brian Kennedy discuss how proteomics, lipidomics, and other biomarkers can provide a holistic view of aging.
#Longevity #HealthyAging #MultiOmics #BrianKennedy
“Methylation clocks are powerful, but in the clinic, changing lives takes more.” 🧬
In Decoding Longevity Ep.14, Dr. Macsue Jacques and Prof. Brian Kennedy explore:
– Why methylation has limits in clinical use
– How biomarkers must evolve for real-world impact
– The future of aging diagnostics
In Decoding Longevity Ep.14, Dr. Macsue Jacques and Prof. Brian Kennedy explore:
– Why methylation has limits in clinical use
– How biomarkers must evolve for real-world impact
– The future of aging diagnostics
October 1, 2025 at 4:26 PM
“Methylation clocks are powerful, but in the clinic, changing lives takes more.” 🧬
In Decoding Longevity Ep.14, Dr. Macsue Jacques and Prof. Brian Kennedy explore:
– Why methylation has limits in clinical use
– How biomarkers must evolve for real-world impact
– The future of aging diagnostics
In Decoding Longevity Ep.14, Dr. Macsue Jacques and Prof. Brian Kennedy explore:
– Why methylation has limits in clinical use
– How biomarkers must evolve for real-world impact
– The future of aging diagnostics
Every biological clock tells a different story. 🕰️
DNA methylation, proteomics, lipidomics — each has strengths, weaknesses, and unique insights into aging.
DNA methylation, proteomics, lipidomics — each has strengths, weaknesses, and unique insights into aging.
September 29, 2025 at 6:25 PM
Every biological clock tells a different story. 🕰️
DNA methylation, proteomics, lipidomics — each has strengths, weaknesses, and unique insights into aging.
DNA methylation, proteomics, lipidomics — each has strengths, weaknesses, and unique insights into aging.
“What if we could measure how fast we’re aging—AND test if lifestyle changes could slow it down?”
In Ep. #14 of Decoding Longevity, Dr. Macsue Jacques hosts Prof. Brian Kennedy for a deep dive into epigenetic clocks, interventions, and the future of healthy aging.
In Ep. #14 of Decoding Longevity, Dr. Macsue Jacques hosts Prof. Brian Kennedy for a deep dive into epigenetic clocks, interventions, and the future of healthy aging.
September 26, 2025 at 6:46 PM
“What if we could measure how fast we’re aging—AND test if lifestyle changes could slow it down?”
In Ep. #14 of Decoding Longevity, Dr. Macsue Jacques hosts Prof. Brian Kennedy for a deep dive into epigenetic clocks, interventions, and the future of healthy aging.
In Ep. #14 of Decoding Longevity, Dr. Macsue Jacques hosts Prof. Brian Kennedy for a deep dive into epigenetic clocks, interventions, and the future of healthy aging.
🎙️ New episode out today!
On Decoding Longevity Ep. #14, Dr. Macsue Jacques welcomes Prof. Brian Kennedy for a fascinating discussion on:
✨ Biological aging clocks that predict mortality
✨ Why modifiable clinical features matter
✨ How science is transforming our approach to longevity
On Decoding Longevity Ep. #14, Dr. Macsue Jacques welcomes Prof. Brian Kennedy for a fascinating discussion on:
✨ Biological aging clocks that predict mortality
✨ Why modifiable clinical features matter
✨ How science is transforming our approach to longevity
September 24, 2025 at 5:48 PM
🎙️ New episode out today!
On Decoding Longevity Ep. #14, Dr. Macsue Jacques welcomes Prof. Brian Kennedy for a fascinating discussion on:
✨ Biological aging clocks that predict mortality
✨ Why modifiable clinical features matter
✨ How science is transforming our approach to longevity
On Decoding Longevity Ep. #14, Dr. Macsue Jacques welcomes Prof. Brian Kennedy for a fascinating discussion on:
✨ Biological aging clocks that predict mortality
✨ Why modifiable clinical features matter
✨ How science is transforming our approach to longevity
🚨 New episode dropped! 🚨
“If we are calling ourselves aging researchers and we haven’t defined aging, I think there is a lack. We need a definition that we can operationalize.” — Prof. Andrea B. Maier, from National University of Singapore
“If we are calling ourselves aging researchers and we haven’t defined aging, I think there is a lack. We need a definition that we can operationalize.” — Prof. Andrea B. Maier, from National University of Singapore
September 15, 2025 at 5:57 PM
🚨 New episode dropped! 🚨
“If we are calling ourselves aging researchers and we haven’t defined aging, I think there is a lack. We need a definition that we can operationalize.” — Prof. Andrea B. Maier, from National University of Singapore
“If we are calling ourselves aging researchers and we haven’t defined aging, I think there is a lack. We need a definition that we can operationalize.” — Prof. Andrea B. Maier, from National University of Singapore