DocVatsa
@docvatsa.bsky.social
GP NHS Scotland, Scientist. Evidence based medicine. COVID. LongCovid. Sports Medicine
Scientists are overrated when fakery is cheaply available and spread from the top.
When we reward an idiot for their idiocy, they believe they are genius.
www.science.org/content/arti...
When we reward an idiot for their idiocy, they believe they are genius.
www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
www.science.org
January 22, 2025 at 11:49 PM
Scientists are overrated when fakery is cheaply available and spread from the top.
When we reward an idiot for their idiocy, they believe they are genius.
www.science.org/content/arti...
When we reward an idiot for their idiocy, they believe they are genius.
www.science.org/content/arti...
Cancer uses a sinister trick to evade the immune system: it hijacks T cells by transferring faulty mitochondria, weakening their ability to fight.
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 22, 2025 at 7:59 PM
Cancer uses a sinister trick to evade the immune system: it hijacks T cells by transferring faulty mitochondria, weakening their ability to fight.
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
Cancer uses a sinister trick to evade the immune system: it hijacks T cells by transferring faulty mitochondria, weakening their ability to fight.
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 22, 2025 at 7:28 PM
Cancer uses a sinister trick to evade the immune system: it hijacks T cells by transferring faulty mitochondria, weakening their ability to fight.
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
This groundbreaking discovery reveals why some immunotherapies fail and opens new paths for treatment.
www.nature.com/articles/s41...
GLP-1 receptor agonists show potential beyond diabetes & obesity, reducing risks of neurocognitive disorders, cardiometabolic issues, & infections, but increase risks of gastrointestinal problems, hypotension, & kidney issues, per a large study on 175 health outcomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping the effectiveness and risks of GLP-1 receptor agonists - Nature Medicine
An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other antihyperglycemic medicat...
www.nature.com
January 22, 2025 at 1:17 PM
GLP-1 receptor agonists show potential beyond diabetes & obesity, reducing risks of neurocognitive disorders, cardiometabolic issues, & infections, but increase risks of gastrointestinal problems, hypotension, & kidney issues, per a large study on 175 health outcomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by DocVatsa
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
November 29, 2024 at 4:01 PM
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
Persistent SARS-CoV-2 spike protein in the skull-meninges-brain axis may drive long COVID neurological symptoms.
Induces neuroinflammation, proteome changes, & worsens outcomes in stroke/brain injury models.
Vaccination reduces but doesn't eliminate accumulation.
#MedSky 🧪
Induces neuroinflammation, proteome changes, & worsens outcomes in stroke/brain injury models.
Vaccination reduces but doesn't eliminate accumulation.
#MedSky 🧪
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying
mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists
in the skull-meninges-brain axis, ...
www.cell.com
November 30, 2024 at 8:59 AM
Persistent SARS-CoV-2 spike protein in the skull-meninges-brain axis may drive long COVID neurological symptoms.
Induces neuroinflammation, proteome changes, & worsens outcomes in stroke/brain injury models.
Vaccination reduces but doesn't eliminate accumulation.
#MedSky 🧪
Induces neuroinflammation, proteome changes, & worsens outcomes in stroke/brain injury models.
Vaccination reduces but doesn't eliminate accumulation.
#MedSky 🧪
🚨 The injectable drug benralizumab significantly reduces asthma and COPD flare-ups by targeting eosinophils, a type of white blood cell involved in inflammation.
This treatment decreases the need for hospitalization by 30%.
Can be a game changer.
#Medsky 🧪
www.news-medical.net/news/2024112...
This treatment decreases the need for hospitalization by 30%.
Can be a game changer.
#Medsky 🧪
www.news-medical.net/news/2024112...
New injection treatment could be a game-changer for people with asthma and COPD
An injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%.
www.news-medical.net
November 29, 2024 at 8:13 AM
🚨 The injectable drug benralizumab significantly reduces asthma and COPD flare-ups by targeting eosinophils, a type of white blood cell involved in inflammation.
This treatment decreases the need for hospitalization by 30%.
Can be a game changer.
#Medsky 🧪
www.news-medical.net/news/2024112...
This treatment decreases the need for hospitalization by 30%.
Can be a game changer.
#Medsky 🧪
www.news-medical.net/news/2024112...
Reposted by DocVatsa
Researchers found that to address the epidemic of mental ill health among HCPs, workers needed:
Targeted MH interventions
Hot food
Rest areas/lockers
Free parking
Essentially staff just need to be valued & treated like human beings.
Rocket science it is not.
evidence.nihr.ac.uk/alert/system...
Targeted MH interventions
Hot food
Rest areas/lockers
Free parking
Essentially staff just need to be valued & treated like human beings.
Rocket science it is not.
evidence.nihr.ac.uk/alert/system...
NHS staff psychological wellbeing: system-level changes needed
System-level changes such as improvements in working conditions are essential in order to improve the psychological wellbeing of NHS staff.
evidence.nihr.ac.uk
November 28, 2024 at 4:59 PM
Researchers found that to address the epidemic of mental ill health among HCPs, workers needed:
Targeted MH interventions
Hot food
Rest areas/lockers
Free parking
Essentially staff just need to be valued & treated like human beings.
Rocket science it is not.
evidence.nihr.ac.uk/alert/system...
Targeted MH interventions
Hot food
Rest areas/lockers
Free parking
Essentially staff just need to be valued & treated like human beings.
Rocket science it is not.
evidence.nihr.ac.uk/alert/system...
Déjà vu!
Atleast adhere to the advice this time, in time.
Atleast adhere to the advice this time, in time.
WHO calls for stronger surveillance of H5N1 bird flu among animals
A World Health Organization official on Thursday called for stronger surveillance in animals for evidence of infection with H5N1 bird flu in order to curb its spread.
www.reuters.com
November 28, 2024 at 10:09 PM
Déjà vu!
Atleast adhere to the advice this time, in time.
Atleast adhere to the advice this time, in time.
Between 2013-2021, cervical cancer mortality in U.S. women under 25 dropped by 62%, thanks to widespread HPV vaccination. Yet, vaccination rates fell to 75.9% in 2023.
Let's prioritize protecting the next generations.
Vaccines Rock no matter what the anti vaxxers claim falsely.
#Medsky 🧪
Let's prioritize protecting the next generations.
Vaccines Rock no matter what the anti vaxxers claim falsely.
#Medsky 🧪
November 28, 2024 at 6:22 AM
Between 2013-2021, cervical cancer mortality in U.S. women under 25 dropped by 62%, thanks to widespread HPV vaccination. Yet, vaccination rates fell to 75.9% in 2023.
Let's prioritize protecting the next generations.
Vaccines Rock no matter what the anti vaxxers claim falsely.
#Medsky 🧪
Let's prioritize protecting the next generations.
Vaccines Rock no matter what the anti vaxxers claim falsely.
#Medsky 🧪
FYI. In case you plan to 'warn' your policy makers by making some noise about this. They should be proactive this time, before it is too late.
H5N1 virus has been spreading in mammals across many countries, and has had human cases too.
www.independent.co.uk/news/health/...
#Medsky 🧪
H5N1 virus has been spreading in mammals across many countries, and has had human cases too.
www.independent.co.uk/news/health/...
#Medsky 🧪
Experts say bird flu is more widespread than we think: ‘We are in a soup of virus’
“We are in a soup of virus. I mean, there’s virus everywhere around us at this point,” one scientist said
www.independent.co.uk
November 27, 2024 at 8:02 AM
FYI. In case you plan to 'warn' your policy makers by making some noise about this. They should be proactive this time, before it is too late.
H5N1 virus has been spreading in mammals across many countries, and has had human cases too.
www.independent.co.uk/news/health/...
#Medsky 🧪
H5N1 virus has been spreading in mammals across many countries, and has had human cases too.
www.independent.co.uk/news/health/...
#Medsky 🧪
New study on COVID-19 vaccines for kids 6-24 months:
Mild reactions like fussiness (30%) and fever (14%) common, severe cases rare (0.3%).
Moderna had slightly higher reaction rates than Pfizer.
Vaccines remain SAFE & effective for young children.
#Medsky 🧪
jamanetwork.com/journals/jam...
Mild reactions like fussiness (30%) and fever (14%) common, severe cases rare (0.3%).
Moderna had slightly higher reaction rates than Pfizer.
Vaccines remain SAFE & effective for young children.
#Medsky 🧪
jamanetwork.com/journals/jam...
November 27, 2024 at 7:52 AM
New study on COVID-19 vaccines for kids 6-24 months:
Mild reactions like fussiness (30%) and fever (14%) common, severe cases rare (0.3%).
Moderna had slightly higher reaction rates than Pfizer.
Vaccines remain SAFE & effective for young children.
#Medsky 🧪
jamanetwork.com/journals/jam...
Mild reactions like fussiness (30%) and fever (14%) common, severe cases rare (0.3%).
Moderna had slightly higher reaction rates than Pfizer.
Vaccines remain SAFE & effective for young children.
#Medsky 🧪
jamanetwork.com/journals/jam...
Current risk for human transmission is low , but the way policy makers are sleeping over the spread , this might change.
We can't be exposing the world to yet another fast spreading deadly virus.
We can't be exposing the world to yet another fast spreading deadly virus.
Avian Influenza A(H5) Outbreak | Center for Outbreak Response Innovation
cori.centerforhealthsecurity.org
November 26, 2024 at 1:59 PM
Current risk for human transmission is low , but the way policy makers are sleeping over the spread , this might change.
We can't be exposing the world to yet another fast spreading deadly virus.
We can't be exposing the world to yet another fast spreading deadly virus.
H5N1 has spread to many countries. This is how it can spread e.g. from cows to humans on a dairy farm.
As always Govts won't act proactively to save the spread so we need to spread the awareness.
#Medsky 🧪
As always Govts won't act proactively to save the spread so we need to spread the awareness.
#Medsky 🧪
November 26, 2024 at 1:43 PM
H5N1 has spread to many countries. This is how it can spread e.g. from cows to humans on a dairy farm.
As always Govts won't act proactively to save the spread so we need to spread the awareness.
#Medsky 🧪
As always Govts won't act proactively to save the spread so we need to spread the awareness.
#Medsky 🧪
Great news that a kit can detect the H5N1 in under three hours. Can differentiate from other avian viruses too. Otherwise it would take a few days.
Can be really helpful in prevention and spread of H5N1.
🧪 #MedSky
Can be really helpful in prevention and spread of H5N1.
🧪 #MedSky
Breakthrough Diagnostic Kit Detects H5N1 Avian Flu in Just 3 Hours
The Steadfast diagnostic kit, developed by DxD Hub, NIES, and A*STAR BII, rapidly detects and distinguishes H5N1 AIV strains, improving outbreak response and global pandemic readiness. The Diagnostics...
search.app
November 25, 2024 at 3:13 PM
Great news that a kit can detect the H5N1 in under three hours. Can differentiate from other avian viruses too. Otherwise it would take a few days.
Can be really helpful in prevention and spread of H5N1.
🧪 #MedSky
Can be really helpful in prevention and spread of H5N1.
🧪 #MedSky
Scientists developed a malaria vaccine using mosquito bites!
🦟 Modified malaria parasites boost immunity without causing disease.
In trials, 89% of participants avoided malaria. Minimal side effects.
A potential game-changer for global malaria control.
www.nature.com/articles/d41...
#MedSky
🦟 Modified malaria parasites boost immunity without causing disease.
In trials, 89% of participants avoided malaria. Minimal side effects.
A potential game-changer for global malaria control.
www.nature.com/articles/d41...
#MedSky
This malaria vaccine is delivered by a mosquito bite
Bites from insects infected with modified malaria parasites boosted immunity and stopped people from contracting the disease.
www.nature.com
November 24, 2024 at 9:22 AM
Scientists developed a malaria vaccine using mosquito bites!
🦟 Modified malaria parasites boost immunity without causing disease.
In trials, 89% of participants avoided malaria. Minimal side effects.
A potential game-changer for global malaria control.
www.nature.com/articles/d41...
#MedSky
🦟 Modified malaria parasites boost immunity without causing disease.
In trials, 89% of participants avoided malaria. Minimal side effects.
A potential game-changer for global malaria control.
www.nature.com/articles/d41...
#MedSky
H5N1 has mutated. No human to human transmission detected yet. Can mutate to acquire that hence the concerns. Causes conjunctivitis and severe lung issues.Older vaccines might help but further research on vaccines ongoing.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Why a teenager’s bird-flu infection is ringing alarm bells for scientists
A strain of avian influenza is showing signs of adaptation to human hosts, but there is no evidence that it can transmit from person to person.
www.nature.com
November 24, 2024 at 9:03 AM
H5N1 has mutated. No human to human transmission detected yet. Can mutate to acquire that hence the concerns. Causes conjunctivitis and severe lung issues.Older vaccines might help but further research on vaccines ongoing.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
COVID is over, right? It is still 'ripping through ' our children n their teachers.
😡
No Cap.
😡
No Cap.
What to make of the rise of the wellbeing sick day
New data shows staff 'wellbeing' absences are rising, as a report warned of 'disturbingly high' stress
schoolsweek.co.uk
November 24, 2024 at 12:47 AM
COVID is over, right? It is still 'ripping through ' our children n their teachers.
😡
No Cap.
😡
No Cap.
Avg hospital stay for COVID in Scotland. Policy makers have stopped caring about the virus and it's impact on the people, but the virus has not stopped it's job.
Thanks to efforts like this graph from @1goodtern.bsky.social that we can still get an overview
#MedSky
Thanks to efforts like this graph from @1goodtern.bsky.social that we can still get an overview
#MedSky
November 24, 2024 at 12:14 AM
Avg hospital stay for COVID in Scotland. Policy makers have stopped caring about the virus and it's impact on the people, but the virus has not stopped it's job.
Thanks to efforts like this graph from @1goodtern.bsky.social that we can still get an overview
#MedSky
Thanks to efforts like this graph from @1goodtern.bsky.social that we can still get an overview
#MedSky
Death rates continue to be much higher in the unvaccinated than the vaccinated for COVID.
Not surprising but worth highlighting, repeatedly.
Not surprising but worth highlighting, repeatedly.
November 23, 2024 at 1:13 PM
Death rates continue to be much higher in the unvaccinated than the vaccinated for COVID.
Not surprising but worth highlighting, repeatedly.
Not surprising but worth highlighting, repeatedly.
H5N1 has been on the move. Spreading. No one wants to hear the P words, but it has the potential for harming us en mass.
Make some noise so that our policy makers wake up well in time than the 'last time'.
Make some noise so that our policy makers wake up well in time than the 'last time'.
November 23, 2024 at 10:44 AM
H5N1 has been on the move. Spreading. No one wants to hear the P words, but it has the potential for harming us en mass.
Make some noise so that our policy makers wake up well in time than the 'last time'.
Make some noise so that our policy makers wake up well in time than the 'last time'.
Only if rationality was the basis of our key decisions, we could easily avoid wars, idiotic policies and lot of troubles of long COVID. Only if.
November 20, 2024 at 9:32 PM
Only if rationality was the basis of our key decisions, we could easily avoid wars, idiotic policies and lot of troubles of long COVID. Only if.
Tirzepatide reduces the risk of cardiovascular death or worsening heart failure and improves health status in patients with HFpEF and obesity. Vs placebo.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
www.nejm.org
November 16, 2024 at 3:25 PM
Tirzepatide reduces the risk of cardiovascular death or worsening heart failure and improves health status in patients with HFpEF and obesity. Vs placebo.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
COVID hastens ageing.
Just that fact should be enough for us to keep protecting ourselves against it.
🧪
Just that fact should be enough for us to keep protecting ourselves against it.
🧪
February 12, 2024 at 6:34 AM
COVID hastens ageing.
Just that fact should be enough for us to keep protecting ourselves against it.
🧪
Just that fact should be enough for us to keep protecting ourselves against it.
🧪