Sounds amazing. I will most likely be a heavy InfinDIA user in the future!

vPro-MS identifies viruses in DIA data with > 99,99% specificity without affecting sensitivity from a database built from > 20,000 genomes. Throughput, quantitation and specificity are already on pair with genomics and sensitivity will most likely increase in the future.

#Proteomics is going viral! We present vPro-MS in @natcomms.nature.com as a diagnostic method for untargeted virus identification from patient samples. www.nature.com/articles/s41...
#TeamMassSpec @rki.de

I was told this does not work because the Opentron Flex is not able to push the liquid stack through the Evotip. It can not push hard enough on the tips. If you should receive a protocol, I would really like to know if it works.

Obviously we report IDs with a certain error in proteomics. I do infectious disease diagnostics with DIA and so correct IDs matter most to me. I don't look at peaks but adjust/develop post processing tools when I need 100% specificity (which is possible),see fig3 here www.medrxiv.org/content/10.1...

After all samples are measured you can trigger such a combined analysis in Proteoscape based on the "real-time" results. It's still much faster than offline search and results for SN19 are quite identical (< 1% PrecursorIds). Plus no need for data transfer.

Spectronaut 19 is currently implemented in Proteoscape. It's not a real time analysis, depending on the gradient length, Spectronaut lags 1 or 2 samples behind data aquisition. After running a sequence, multiple samples can be combined in a "second" search. It's convenient. We use it a lot.