Daniel Ortiz-Barrientos
@dortizba.bsky.social
Evolutionary Geneticist at UQ, Australia. Speciation, adaptation, future resilience. #senecio
Pinned
We’ve just published a paper on Senecio showing that ecological speciation and mutation-order speciation can act together rather than as an either/or. Congratulations, Maddie James and MC Melo!
Reposted by Daniel Ortiz-Barrientos
The emergence and diversification of dog morphology 🏺🧪
www.science.org/doi/10.1126/...
This study looked at more than 640 canid crania over the past 50,000 years (see the Perspective by Fillios) and found that by the beginning of the Holocene, dogs already displayed extensive variation.
www.science.org/doi/10.1126/...
This study looked at more than 640 canid crania over the past 50,000 years (see the Perspective by Fillios) and found that by the beginning of the Holocene, dogs already displayed extensive variation.
November 21, 2025 at 5:30 PM
The emergence and diversification of dog morphology 🏺🧪
www.science.org/doi/10.1126/...
This study looked at more than 640 canid crania over the past 50,000 years (see the Perspective by Fillios) and found that by the beginning of the Holocene, dogs already displayed extensive variation.
www.science.org/doi/10.1126/...
This study looked at more than 640 canid crania over the past 50,000 years (see the Perspective by Fillios) and found that by the beginning of the Holocene, dogs already displayed extensive variation.
Reposted by Daniel Ortiz-Barrientos
Globalization has accelerated the spread of mosquito species that transmit human diseases. An analysis in Nature Communications shows that 45 disease-vector mosquito species have been introduced to non-native regions worldwide. go.nature.com/4hn6ogW 🧪
October 25, 2025 at 7:07 PM
Globalization has accelerated the spread of mosquito species that transmit human diseases. An analysis in Nature Communications shows that 45 disease-vector mosquito species have been introduced to non-native regions worldwide. go.nature.com/4hn6ogW 🧪
Reposted by Daniel Ortiz-Barrientos
Exploring 599 genomes from 387 plant species, 20 OSCs were functionally evaluated, revealing immense triterpenoid diversity. PMID:41053430, Nat Chem Biol 2025, @nchembio https://doi.org/10.1038/s41589-025-02034-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Large-scale mining of plant genomes unlocks the diversity of oxidosqualene cyclases | Nature Chemical Biology
The differential cyclization and rearrangement of 2,3-oxidosqualene controlled by oxidosqualene cyclases (OSCs) represents one of the most complex single enzyme transformations in nature and gives rise to a vast array of triterpenoid diversity in the plant kingdom. Here we systematically mine 599 plant genomes representing 387 species and investigate OSC diversity across different plant lineages. From the OSC sequences identified, 20 were selected for functional evaluation. Through analysis of these enzymes, we discover product profiles within clades previously believed to be functionally conserved and OSCs producing triterpenes for which no enzymatic source was known. We also discover OSCs with product profiles that yield mechanistic insights into the control of specific reaction pathways. Our study reveals lineage-specific blooms of OSC subgroups suggestive of adaptation to different environmental niches, opens up previously inaccessible chemistry and provides a framework for systema
doi.org
October 25, 2025 at 9:00 PM
Reposted by Daniel Ortiz-Barrientos
We are looking for a physics/maths graduate with an interest in biology, or a biology graduate with strong computational/mathematical skills/interests, to join us as a PhD student working on biomechanical modelling of butterfly wing scale structure formation www.findaphd.com/phds/project...
October 23, 2025 at 4:33 PM
We are looking for a physics/maths graduate with an interest in biology, or a biology graduate with strong computational/mathematical skills/interests, to join us as a PhD student working on biomechanical modelling of butterfly wing scale structure formation www.findaphd.com/phds/project...
Origins and genetic legacy of prehistoric dogs | Science www.science.org/doi/10.1126/...
Origins and genetic legacy of prehistoric dogs
Ancient dog genomes elucidate diversification and a complex genetic history relative to that of humans.
www.science.org
October 25, 2025 at 2:45 AM
Origins and genetic legacy of prehistoric dogs | Science www.science.org/doi/10.1126/...
genetic basis of natural variation in sociability url: academic.oup.com/evolut/artic...
The genetic basis of natural variation in sociability
Abstract. Sociability, defined as individuals’ tendencies to affiliate with conspecifics, is widespread among animals, including species not traditionally
academic.oup.com
October 24, 2025 at 4:18 AM
genetic basis of natural variation in sociability url: academic.oup.com/evolut/artic...
Reposted by Daniel Ortiz-Barrientos
Some ancient stony corals were able to survive extreme environmental changes, which suggests that some modern species could possess some resilience to the effects of climate change, according to research in Nature. go.nature.com/4hrpLpi 🌊 🧪
October 23, 2025 at 4:27 PM
Some ancient stony corals were able to survive extreme environmental changes, which suggests that some modern species could possess some resilience to the effects of climate change, according to research in Nature. go.nature.com/4hrpLpi 🌊 🧪
Reposted by Daniel Ortiz-Barrientos
Cool paleo-🧵about the last dinosaurs from 66 mya in what's now New Mexico, & how their fossil record points toward diverse communities during the last few hundred-thousand years before a demise-inducing meteorite impact. Article in @science.org at the link: www.science.org/doi/10.1126/... 🧪🦖🦕☄️
October 23, 2025 at 7:19 PM
Cool paleo-🧵about the last dinosaurs from 66 mya in what's now New Mexico, & how their fossil record points toward diverse communities during the last few hundred-thousand years before a demise-inducing meteorite impact. Article in @science.org at the link: www.science.org/doi/10.1126/... 🧪🦖🦕☄️
Reposted by Daniel Ortiz-Barrientos
Just in time for spooky season: DINOSAUR "MUMMIES!"
Unlike Egyptian mummies, these don't have squishy bits preserved, but the rock around these carcasses had clay capturing texture of scales, a midline crest w/ keratin spikes, &, brand new, feet w/ hooves! 🧪⚒️🦕🦖
www.science.org/doi/10.1126/...
Unlike Egyptian mummies, these don't have squishy bits preserved, but the rock around these carcasses had clay capturing texture of scales, a midline crest w/ keratin spikes, &, brand new, feet w/ hooves! 🧪⚒️🦕🦖
www.science.org/doi/10.1126/...
October 23, 2025 at 7:31 PM
Just in time for spooky season: DINOSAUR "MUMMIES!"
Unlike Egyptian mummies, these don't have squishy bits preserved, but the rock around these carcasses had clay capturing texture of scales, a midline crest w/ keratin spikes, &, brand new, feet w/ hooves! 🧪⚒️🦕🦖
www.science.org/doi/10.1126/...
Unlike Egyptian mummies, these don't have squishy bits preserved, but the rock around these carcasses had clay capturing texture of scales, a midline crest w/ keratin spikes, &, brand new, feet w/ hooves! 🧪⚒️🦕🦖
www.science.org/doi/10.1126/...
Reposted by Daniel Ortiz-Barrientos
Learn to create and publish a professional, data-focused website in “Create an Online Presence with Quarto Websites” on October 16-17, with @andrew.heiss.phd! Discover how to use #Quarto to build a variety of websites like personal portfolios, research compendiums, and interactive dashboards.
Quarto Websites | Online Seminar | Code Horizons
This online course taught by Andrew Heiss, Ph.D., teaches you how to use Quarto to build a variety of data-focused websites.
codehorizons.com
September 18, 2025 at 12:51 PM
Learn to create and publish a professional, data-focused website in “Create an Online Presence with Quarto Websites” on October 16-17, with @andrew.heiss.phd! Discover how to use #Quarto to build a variety of websites like personal portfolios, research compendiums, and interactive dashboards.
Reposted by Daniel Ortiz-Barrientos
Our paper (Brieuc Lehmann is the first author) is now online in Genetics.
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
On ARGs, pedigrees, and genetic relatedness matrices
Abstract. Genetic relatedness is a central concept in genetics, underpinning studies of population and quantitative genetics in human, animal, and plant se
academic.oup.com
October 9, 2025 at 1:47 AM
Our paper (Brieuc Lehmann is the first author) is now online in Genetics.
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Reposted by Daniel Ortiz-Barrientos
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Reposted by Daniel Ortiz-Barrientos
A new high-coverage #Denisovan genome, chock-full of fascinating new information. Must-read study by @stephanepeyregne.bsky.social @janetk.bsky.social and colleagues
On @biorxivpreprint.bsky.social: 🧪🧬
www.biorxiv.org/content/10.1...
On @biorxivpreprint.bsky.social: 🧪🧬
www.biorxiv.org/content/10.1...
A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
www.biorxiv.org
October 21, 2025 at 4:58 AM
A new high-coverage #Denisovan genome, chock-full of fascinating new information. Must-read study by @stephanepeyregne.bsky.social @janetk.bsky.social and colleagues
On @biorxivpreprint.bsky.social: 🧪🧬
www.biorxiv.org/content/10.1...
On @biorxivpreprint.bsky.social: 🧪🧬
www.biorxiv.org/content/10.1...
Reposted by Daniel Ortiz-Barrientos
Worth checking out if you do statistical analysis in your research. statcheck.io
statcheck // web
statcheck.io
October 20, 2025 at 6:15 PM
Worth checking out if you do statistical analysis in your research. statcheck.io
Reposted by Daniel Ortiz-Barrientos
Long runs of homozygosity are reliable genomic markers of inbreeding depression 🧬 www.cell.com/trends/ecolo...
Long runs of homozygosity are reliable genomic markers of inbreeding depression
A long-standing goal in ecological, evolutionary, and conservation genetics is to
identify genomic correlates of fitness and inbreeding depression. Over the past several
years, a growing body of theor...
www.cell.com
August 4, 2025 at 7:51 AM
Long runs of homozygosity are reliable genomic markers of inbreeding depression 🧬 www.cell.com/trends/ecolo...
Reposted by Daniel Ortiz-Barrientos
Taming the reference genome jungle: the refget sequence collection standard. #ReferenceGenomes #Transcriptomes #SequenceCollectionStandards #GA4GH @biorxiv-genomic.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 8:31 AM
Taming the reference genome jungle: the refget sequence collection standard. #ReferenceGenomes #Transcriptomes #SequenceCollectionStandards #GA4GH @biorxiv-genomic.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Daniel Ortiz-Barrientos
Myself and Alastair Wilson wrote an updated version of our 2016 primer to quantitative genetics in the wild: www.sciencedirect.com/science/arti.... Happy to share a copy if interested. It is also on research gate
Quantitative Genetics in Natural Populations
Phenotypes evolve under natural selection if, and only if, they are genetically variable. While evolutionary ecologists have long studied natural sele…
www.sciencedirect.com
October 21, 2025 at 4:31 PM
Myself and Alastair Wilson wrote an updated version of our 2016 primer to quantitative genetics in the wild: www.sciencedirect.com/science/arti.... Happy to share a copy if interested. It is also on research gate
Reposted by Daniel Ortiz-Barrientos
This collaboration was so much fun!! I’m excited to see it online! www.cell.com/trends/genet...
August 9, 2025 at 1:24 PM
This collaboration was so much fun!! I’m excited to see it online! www.cell.com/trends/genet...
Reposted by Daniel Ortiz-Barrientos
📣Online NOW!
📄Estimation of demography and mutation rates from one million haploid genomes
🧑🤝🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social
📄Estimation of demography and mutation rates from one million haploid genomes
🧑🤝🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social
Estimation of demography and mutation rates from one million haploid genomes
Samples of millions of genomes provide substantial information about recent demography
and mutation, but standard population-genetic methods make assumptions not met in
these data. We introduce DR EVI...
www.cell.com
August 13, 2025 at 2:40 PM
📣Online NOW!
📄Estimation of demography and mutation rates from one million haploid genomes
🧑🤝🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social
📄Estimation of demography and mutation rates from one million haploid genomes
🧑🤝🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social
Reposted by Daniel Ortiz-Barrientos
alignments are mosaics of autocorrelated genealogies... nearby bases share ancestry until recombination alters the local tree. We derived the distributions of waiting distances for tree-change and topology-change events, extending prior single-population results to arbitrary species tree models.
September 11, 2025 at 7:40 PM
alignments are mosaics of autocorrelated genealogies... nearby bases share ancestry until recombination alters the local tree. We derived the distributions of waiting distances for tree-change and topology-change events, extending prior single-population results to arbitrary species tree models.
Reposted by Daniel Ortiz-Barrientos
Hybridization and introgression are major evolutionary processes. Since the 1940s, the prevailing view has been that they shape plants far more than animals. In our new study (www.science.org/doi/10.1126/...
), we find the opposite: animals exchange genes more, and for longer, than plants
), we find the opposite: animals exchange genes more, and for longer, than plants
September 12, 2025 at 7:55 AM
Hybridization and introgression are major evolutionary processes. Since the 1940s, the prevailing view has been that they shape plants far more than animals. In our new study (www.science.org/doi/10.1126/...
), we find the opposite: animals exchange genes more, and for longer, than plants
), we find the opposite: animals exchange genes more, and for longer, than plants
Reposted by Daniel Ortiz-Barrientos
I'm so proud of this work!!! It was an incredible amount of effort that started when I was trapped in a greenhouse during the pandemic and is only now seeing the light of day. Kudos to Megan, Hagar, & Pia!
We'd love to hear your thoughts!
www.biorxiv.org/content/10.1...
We'd love to hear your thoughts!
www.biorxiv.org/content/10.1...
Introgression and Parental Conflict Underlie Repeated Occurrences of Postzygotic Isolation
Postzygotic reproductive isolation is often thought to accumulate as a byproduct of neutral divergence. Yet, it frequently evolves rapidly, in line with non-neutral evolution. A major driver of intrin...
www.biorxiv.org
September 25, 2025 at 9:29 PM
I'm so proud of this work!!! It was an incredible amount of effort that started when I was trapped in a greenhouse during the pandemic and is only now seeing the light of day. Kudos to Megan, Hagar, & Pia!
We'd love to hear your thoughts!
www.biorxiv.org/content/10.1...
We'd love to hear your thoughts!
www.biorxiv.org/content/10.1...
Excited to share our new paper in
@GeneticsGSA
! We developed "Retriever," a novel method that enables high-quality genotype imputation in non-model organisms. 🧬 Congratulations to Charles on his first PhD paper!
Paper: doi.org/10.1093/gene...
A thread 🧵👇
@GeneticsGSA
! We developed "Retriever," a novel method that enables high-quality genotype imputation in non-model organisms. 🧬 Congratulations to Charles on his first PhD paper!
Paper: doi.org/10.1093/gene...
A thread 🧵👇
Chimeric Reference Panels for Genomic Imputation
Abstract. Despite transformative advances in genomic technologies, missing data remains a fundamental constraint that limits the full potential of genomic
doi.org
October 2, 2025 at 2:37 AM
Excited to share our new paper in
@GeneticsGSA
! We developed "Retriever," a novel method that enables high-quality genotype imputation in non-model organisms. 🧬 Congratulations to Charles on his first PhD paper!
Paper: doi.org/10.1093/gene...
A thread 🧵👇
@GeneticsGSA
! We developed "Retriever," a novel method that enables high-quality genotype imputation in non-model organisms. 🧬 Congratulations to Charles on his first PhD paper!
Paper: doi.org/10.1093/gene...
A thread 🧵👇
Reposted by Daniel Ortiz-Barrientos
News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n
History of Molecular Biology Collection
This unparalleled collection includes Rosalind Franklin's historic 'Photo 51,' which revealed the double-helix structure of DNA.
www.sciencehistory.org
September 8, 2025 at 12:28 PM
News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n
Reposted by Daniel Ortiz-Barrientos
September 3, 2025 at 5:19 PM