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Tom Ambrosi @drambrosi.bsky.social · Aug 15

Some good lab news among all the turmoil! Excited about this new publication in collab with Dr. Nancy Lane. Great effort by graduate student Dave & postdoc Kun! Looking forward to presenting this & more at @asbmr.bsky.social meet next month! @ucdavishealth.bsky.social www.nature.com/articles/s41...

Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis - Nature Communications

Glucocorticoid (GC) induced osteoporosis (GIOP) remains a significant clinical problem. Here, the authors find that GCs disrupt skeletal stem cell–endothelial crosstalk via Basigin that can be targete...

www.nature.com

Reposted by Tom Ambrosi

Sarah CP Williams @sarahcpwilliams.bsky.social · May 23

Stronger bones? A @cp-cellstemcell.bsky.social study by @drambrosi.bsky.social of @ucdavis.bsky.social, funded in part by @wutsaialliance.bsky.social, shed light on how skeletal stem cells change with age and how to boost their fracture-healing abilities. humanperformancealliance.org/news/skeleta...

Skeletal stem cells key to stronger bones, better healing - Wu Tsai Human Performance Alliance

humanperformancealliance.org

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Reposted by Tom Ambrosi

Jeremy Berg @jeremymberg.bsky.social · Apr 30

4/n

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Tom Ambrosi @drambrosi.bsky.social · Mar 20

Grateful during these uncertain times to have had the support to continue Chuck's legacy. @ucdavis.bsky.social, @ucsandiego.bsky.social, Stanford University, @czbiohub.bsky.social www.cell.com/cell-stem-ce...

www.cell.com

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Tom Ambrosi @drambrosi.bsky.social · Mar 20

I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally testing four distinct hS...

www.cell.com

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Tom Ambrosi @drambrosi.bsky.social · Mar 12

We do have a “SSC diversity” grant🫣

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Reposted by Tom Ambrosi

Jan Nolta, PhD @jannolta.bsky.social · Mar 11

Congratulations to Dr. Ambrosi and grad student Kelly Weldon of @UCDavisHealth for this important manuscript! 👏🏻👏🏻👏🏻
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...

Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration

Abstract. In our aging society, the degeneration of the musculoskeletal system and adjacent tissues is a growing orthopedic concern. As bones age, they bec

academic.oup.com

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Reposted by Tom Ambrosi

Laura Helmuth @laurahelmuth.bsky.social · Feb 13

Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.

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Reposted by Tom Ambrosi

tdcapellini.bsky.social @tdcapellini.bsky.social · Feb 13

8/ BOTTOM LINE: NIH BUDGET CUTS WILL MARKEDLY HURT EVERY STATE IN THIS UNION. AND RED ONES RELATIVELY MORE. REPUBLICAN & DEMOCRATIC REPS IN EACH STATE SHOULD BE LASER FOCUSED ON NOT PASSING REFORMS OR ALLOWING EXECUTIVE ORDERS TO FLY THAT HURT REVENUE GENERATION & JOB PROSPECTS. THIS HURTS PEOPLE!

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Reposted by Tom Ambrosi

Emily Goldberg @dremilygoldberg.bsky.social · Feb 10

Check the comments for links to opportunities!

Laura White @laurakwhite.bsky.social · Feb 10

Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.

The War on Science (Feb 2025 teach-in draft)

The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...

docs.google.com

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Tom Ambrosi @drambrosi.bsky.social · Jan 27

New and first pre-print of the lab. Fun project with Nancy Lane @ucdavis.bsky.social. Feedback welcome. www.biorxiv.org/content/10.1...

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

Glucocorticoid (GC) induced osteoporosis (GIOP) and osteonecrosis remain a significant health issue with few approved therapies that can treat the bone loss and dysfunction of skeletal vasculature. Th...

www.biorxiv.org

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Tom Ambrosi @drambrosi.bsky.social · Dec 9

Getting started on this platform by sharing this small year in review I wrote.
rdcu.be/d2U69

Surveying the landscape of emerging osteoanabolic therapies

Nature Reviews Endocrinology - Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies — although more effective — have...

rdcu.be

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Reposted by Tom Ambrosi

Jan Nolta, PhD @jannolta.bsky.social · Nov 25

Here is an excellent publication with some of the important work in brain-bone signaling from @drambrosi.bsky.social and team.

www.nature.com/articles/s41...

A maternal brain hormone that builds bone - Nature

A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.

www.nature.com

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