Lightnews — Scholar-powered news

Dr Lipid @drlipid.bsky.social · 8h

PCSK9I are null, but importantly as previously shown in other studies, no negative effect on brain

Dr Lipid @drlipid.bsky.social · 1d

Want to know where Lipidology is going and some of the new drugs? Check out this open access chat by two giants in the field entitled "Pharmacotherapy Development and Trends in Lipidology: An Expert Discussion" www.lipidjournal.com/article/S1933-2874(25)00423-4/fulltext @nationallipid.bsky.social

Pharmacotherapy Development and Trends in Lipidology: An Expert Discussion

Cardiovascular diseases are leading causes of morbidity and mortality in the United States and globally. Atherosclerotic cardiovascular diseases (ASCVD), such as coronary heart disease and cerebrovasc...

www.lipidjournal.com

6

Dr Lipid @drlipid.bsky.social · 3d

Good news: except for those who think lowering cholesterol is averse to the brain health - lipid Rx lessens AD risk - doi.org/10.1002/alz.... @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @menopausesociety.bsky.social

Cholesterol‐lowering drug targets reduce risk of dementia: Mendelian randomization and meta‐analyses of 1 million individuals

INTRODUCTION We tested whether genetically proxied non-high-density lipoprotein cholesterol (non-HDL-C)–lowering drug targets reduce risk of all-cause dementia. METHODS We included 1,091,775 indiv...

doi.org

1 4

Dr Lipid @drlipid.bsky.social · 5d

Largest Genetic Map of Human Metabolism Created www.genengnews.com/topics/omics/largest-genetic-map-of-human-metabolism-created/?_hsenc=p2ANqtz-91bnPkmKE91xebzRVH0Sk_YOwEUP1hqLENx5M4nH3HxbJ8UgWRgTHcdxNSUgCq6ON-pgUEeVDbhWrSpjcIXLtosJAXsA&_hsmi=383855604 @nationallipid.bsky.social

Largest Genetic Map of Human Metabolism Created

The largest genetic map of human metabolism reveals new insights on the role of metabolites in health and disease.

www.genengnews.com

3

Dr Lipid @drlipid.bsky.social · 9d

Many thanks to FUNDACION CARDIOINFANTIL of Bogota Columbia, for the invitation and high honor to lecture virtually at their Cardiovascular Congress today on the topic of Lipid and Lipoprotein complexities. It was a pleasure to join with my long-time Argentinian colleague & Lipidologist Pablo Coral

1

Dr Lipid @drlipid.bsky.social · 11d

Very important to understand the nuances of Hemoglobin A1C testing - myadlm.org/cln/articles... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social

Navigating hemoglobin A1C measurements for diabetes care

Given the importance of HbA1c in managing diabetes, it’s important for clinical lab professionals and healthcare providers to understand how results can be influenced by various factors, including ana...

myadlm.org

7

Dr Lipid @drlipid.bsky.social · 20d

What is the size of the thrombus in a coronary artery that can send one to Heaven or the CCU? Coronary artery lumens are quite small, and a cholesterol-rich plaque rupture or erosion will induce a thrombus. A tiny thrombus will partially block (cause ischemia) or totally block (cause infarction).

7

Dr Lipid @drlipid.bsky.social · 22d

On this podcast, I along with an oncologist (speaking about cancer) and I on lipids had the opportunity to educate a very different crowd - the Finance World - I was a guest on Jimmie Lee's The Bull of Wall Street Podcast - My section starts at 21:23 - Enjoy www.youtube.com/watch?v=FPSE...

2

Dr Lipid @drlipid.bsky.social · 24d

To further confuse the EPA vs EPA+DHA story. Here is new data from STRENGTH showing EPA + DHA reduced MACE in Asian patients. Authors had no reasons but perhaps due to Asian incidence of IR and TG issues. www.atherosclerosis-journal.com/article/S002...

4

Dr Lipid @drlipid.bsky.social · 25d

DHA is crucial for maintaining brain neuron integrity and may inhibit tau phosphorylation. High doses (0.9–1.8 g/d) of DHA/EPA have shown improvements in cognitive function, while low doses (0.3–0.7 g/d) did not. www.sciencedirect.com/science/article/pii/S0002916523463204?via%3Dihub

9

Dr Lipid @drlipid.bsky.social · Sep 10

Learn why specific sterol measurements are tools to evaluate cholesterol synthesis/absorption - then entertain - an at this time a hypothesis why some degree of reducing brain cholesterol synthesis will likely reduce dementia (in those prone to it) pharmacypodcastnetwork.podbean.com/e/desmostero...

Desmosterol, Statins, and Cognition | Geriatric Pharmacy Focus | Pharmacy Podcast Network

This is a fascinating podcast episode from Dr. Lipid himself on desmosterol. What is it? How do we measure it? Why should we care?Pharmacists are well-positioned to guide patients in understanding ...

pharmacypodcastnetwork.podbean.com

4

Dr Lipid @drlipid.bsky.social · Sep 4

That confirms the first LDL-P was indeed, as suspected a false positive

1

Dr Lipid @drlipid.bsky.social · Sep 4

Yes the cholesterol in RBC can be transferred to lipoproteins, albumin or reused in reticuloendothelial system or marrow

1

Dr Lipid @drlipid.bsky.social · Sep 2

What's a better way to kill an hour+ other that viewing @theproof with Simon Hill interviewing Daniel Soffer and Thomas Dayspring, MD FACP, FNLA reviewing Lipid-modulating medications - theproof.com/lowering-cho... @aspcardio.bsky.social @nationallipid.bsky.social @familyheartfdn.bsky.social

Lowering cholesterol with medicine | Dr Thomas Dayspring and Dr Dan Soffer

In this episode of The Proof, I’m joined once again by two of the world’s leading lipid experts, Dr Tom Dayspring and Dr Dan Soffer. Together we take a deep dive into the world of lipid-lowering thera...

theproof.com

7

Dr Lipid @drlipid.bsky.social · Sep 2

In such a case there’s discordance between apoB and LDL-P. Likely the LDL-P is a false positive. The apoB, LDLc and Non-HDL-C are all concordant and thus believable.

1 1

Dr Lipid @drlipid.bsky.social · Sep 1

"Understanding the Lipid Panel" - next are insights on Non-HDL-C which refers (1) to the mass (weight) in mg of cholesterol within all of the apoB-containing lipoproteins per dL or (2) the number (in mmols) of cholesterol molecules in all the apoB-particles per L.

1 4

Dr Lipid @drlipid.bsky.social · Aug 29

Review the chaos at CDC - in a real medical journal www.science.org/content/article/attempt-oust-cdc-director-sparks-key-resignations-agency-officials?utm_source=sfmc&utm_medium=email&utm_campaign=ScienceAdviser&utm_content=breaking&et_rid=17091364&et_cid=5718570

Attempt to oust CDC director sparks key resignations by agency officials

Susan Monarez, who clashed with the U.S. health secretary over vaccine policy, refuses to step down

www.science.org

5

Dr Lipid @drlipid.bsky.social · Aug 27

Part 2 of my discussion with @_CynthiaThurlow on her Everyday Wellness Podcast where we continue the journey into lipid/lipoprotein issues with an emphasis on women www.youtube.com/watch?v=IoKZvN8BWbg&t=139s @aspcardio.bsky.social @familyheartfdn.bsky.social @nationallipid.bsky.social

4

Dr Lipid @drlipid.bsky.social · Aug 23

Periodically I repost this very useful document (glossary of terms) for those try to master lipids/lipoproteins. Print it out - peterattiamd.com/glossary-lip... @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social

Narrative glossary: lipids - Peter Attia

A companion post for the podcast episodes with Thomas Dayspring, M.D., FACP, FNLA (October 15-19, 2018).

peterattiamd.com

2 5

Dr Lipid @drlipid.bsky.social · Aug 22

Introducing Vishnu Priya Pulipati, MD, FACE, who is an internist/endocrinologist/lipidologist who also did a preventive cardiology fellowship & now practices in Tulsa, OK. Check out her podcast to help clinicians better understand lipids. Please provide feedback to her. lipidcurious.com

LipidCurious

LipidCurious is a podcast for clinicians who want practical, evidence-based clarity in lipid management

lipidcurious.com

7

Dr Lipid @drlipid.bsky.social · Aug 22

I just discovered that there is a pretty good, animated lecture of mine (Grand Rounds Presentation from September 2020) describing a lot of useful lipid and lipid profile basics. Enjoy - www.youtube.com/watch?v=uYZd... @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

Grand Rounds - Dr Tom Dayspring 9/24/20

YouTube video by Advocate Christ Internal Medicine Residency

www.youtube.com

2 1 10

Dr Lipid @drlipid.bsky.social · Aug 22

Insights on HDL-C reported as (1) mass (weight in mg) of all of the cholesterol molecules within all of the HDLs per dL of plasma or (2) the NUMBER of all of the cholesterol molecules in HDLs er liter [mmols). HDL-C or HDL-P have no relationship HDL functionality or reverse cholesterol transport

6

Dr Lipid @drlipid.bsky.social · Aug 18

"Understanding the Lipid Panel" - LDL-C reported as (1) the mass (weight in mg) or the # (mmols) of all of the cholesterol molecules within all of the IDLs and LDLs circulating in a dL of plasma LDL-C is calculated, directly measured, or assayed as the gold standard assay termed beta-quantification

7

Dr Lipid @drlipid.bsky.social · Aug 14

That is a big reason why these risk calculators are useless. Base your risk on causal risk factors BP, apoB, Lp(a), smoking history and noncausal
risk markers

1

Dr Lipid @drlipid.bsky.social · Aug 14

Revisiting my series "Understanding the Lipid Panel" - 1 metric at a time starting with Total Cholesterol. The lipid panel reports lipid mass concentrations but not the lipoprotein concentrations. In essence lipid concentrations are simply guesstimates or surrogates of lipoprotein concentrations.

1 7