Author | Lightnews

Reposted by Dustin Scheinost

Yale Kavli Institute for Neuroscience @kavliatyale.bsky.social · 22d

In a recent @cp-neuron.bsky.social study, @dscheinost.bsky.social and @yaleschoolofmed.bsky.social's Jean Ye found that neural variability 🧠—brain fluctuations that support flexible behavior—increases 📈 through childhood 👶before stabilizing in adolescence🧍

Brain Activity is Increasingly Variable During Development

Fluctuations in brain activity increase until mid-adolescence. Deviations from this trajectory are linked to worse executive functioning.

medicine.yale.edu

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Dustin Scheinost @dscheinost.bsky.social · Sep 24

This developmental trajectory is consistent across four datasets, with deviations from this trajectory associated with poorer executive function. Girls also peaked earlier than boys. @yalebiomedimaging.bsky.social @yaleschoolofmed.bsky.social

sciencedirect.com/science/arti...

Variation in moment-to-moment brain state engagement follows a consistent trajectory during development

Neural variability, or variation in brain signals, facilitates dynamic brain responses to ongoing demands. This flexibility is important during develo…

sciencedirect.com

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Dustin Scheinost @dscheinost.bsky.social · Sep 24

Excited to share our work now out in @cp-neuron.bsky.social !!! We found that during development, people become more variable in how much they engage recurring brain states.

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Reposted by Dustin Scheinost

Jason Bini, PhD @sciencedrbini.bsky.social · Jul 28

Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology

link.springer.com/article/10.1...

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Reposted by Dustin Scheinost

Emma Margolis @emma-margolis.bsky.social · Feb 14

It is more important than ever to promote inclusive & representative science as best scientific practice. In this new paper, we highlight modality-level (MRI, MEG, EEG, fNIRS, ultrasound) obstacles & initiatives for improved inclusivity in FIT neuroimaging. doi.org/10.1016/j.dcn.2024.101505

Screenshot of paper titled "Modality-level obstacles and initiatives to improve representation in fetal, infant, and toddler neuroimaging research samples" with authors: Emma T. Margolis, Paige M. Nelson, Abigail Fiske, Juliette L.Y. Champaud, Halie A. Olson, Maria José C. Gomez, Áine T. Dineen, Chiara Bulgarelli, Sonya V. Troller-Renfree, Kirsten A. Donald, Marisa N. Spann, Brittany Howell, Dustin Scheinost, and Marta Korom.

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Reposted by Dustin Scheinost

Yale Kavli Institute for Neuroscience @kavliatyale.bsky.social · Jan 29

📢 In a new study, @yaleschoolofmed.bsky.social's Jean Ye, @evgoldfarb.bsky.social, & @dscheinost.bsky.social found that people with opioid use disorder had less cognitive flexibility in engaging different brain states 🧠after viewing opioid-related images💊📷

Read More 👇

Opioid use disorder might lead to ‘sticky’ brains

Individuals with opioid use disorder were less able to flexibly engage different patterns of brain activity, Yale researchers found.

news.yale.edu

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Reposted by Dustin Scheinost

Abi Fiske (she/her) @abifiske.bsky.social · Jan 6

Happy New Year! The first working day of 2025 is off to a FANTASTIC start, with news that our paper with the FITNG Trainee Committee @fitngin.bsky.social has been accepted for publication in DCN! Wahooooooo 🥳 www.sciencedirect.com/science/arti...

Modality-Level Obstacles and Initiatives to Improve Representation in Fetal, Infant, and Toddler Neuroimaging Research Samples

Fetal, infant, and toddler (FIT) neuroimaging researchers study early brain development to gain insights into neurodevelopmental processes and identif…

www.sciencedirect.com

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Reposted by Dustin Scheinost

Dustin Scheinost @dscheinost.bsky.social · Jan 22

Thrilled to share Jean Ye’s latest paper on brain dynamics in opioid use disorder (OUD), using resting-state, task-based, and naturalistic fMRI! Check it out at Jama Network Open: jamanetwork.com/journals/jam...

Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder

This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...

jamanetwork.com

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Dustin Scheinost @dscheinost.bsky.social · Jan 22

We found reduced brain state flexibility in OUD, with inflexible dynamics linked to lower cognitive control—especially after viewing opioid-related images. Curious about our brain state flexibility methods? See
Jean’s previous work for details: www.biologicalpsychiatryjournal.com/article/S000...

Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States

Individuals with bipolar disorder (BD) and schizophrenia (SCZ) show aberrant brain dynamics (i.e., altered recruitment or traversal through different brain states over time). Existing investigations o...

www.biologicalpsychiatryjournal.com

Dustin Scheinost @dscheinost.bsky.social · Jan 22

Thrilled to share Jean Ye’s latest paper on brain dynamics in opioid use disorder (OUD), using resting-state, task-based, and naturalistic fMRI! Check it out at Jama Network Open: jamanetwork.com/journals/jam...

Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder

This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...

jamanetwork.com

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