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Exploring Brain Mechanics

@ebmresearch.bsky.social

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Official account of the Collaborative Research Center (CRC 1540) Exploring Brain 🧠 Mechanics funded by @dfgpublic.bsky.social @fau.de Charité Berlin Universität Bonn MPI Light Homepage: https://www.crc1540-ebm.research.fau.eu/

www.crc1540-ebm.research.fau.eu

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Exploring Brain Mechanics @ebmresearch.bsky.social · 7d

☀️ On Sept 28, EBM members & families met at the Entlas-Keller in Erlangen. Sunshine, Franconian food, and good company made for a relaxed afternoon to reconnect after summer and recharge before the busy months ahead. Thanks to all who came by! 🍻

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Exploring Brain Mechanics @ebmresearch.bsky.social · 11d

💻 Mathar Kravikass (C01) showed a model of how neurons interact with different extracellular matrix environments, offering insights into network development.

📸 Stefan Rampp

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Exploring Brain Mechanics @ebmresearch.bsky.social · 11d

At the 15th EBM (Post)Doctoral Researchers' seminar on September 18th, two projects were presented.

🧠 Stefan Rampp (A02) presented how cortical malformations can be characterized by neuroimaging and linking these findings to brain tissue mechanics.

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Exploring Brain Mechanics @ebmresearch.bsky.social · 20d

From left to right: Aldo R. Boccaccini, Prof. Nicholas Dunne (President of the ESB), and Prof. Maria Pau Ginebra (Chair of the ESB Awards Committee). (Copyright: European Society for Biomaterials, ESB)

www.crc1540-ebm.research.fau.eu/2025/09/10/p...

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Exploring Brain Mechanics @ebmresearch.bsky.social · 20d

A global authority in bioactive materials, tissue engineering, and nanomaterials, he has authored 1,100+ papers and mentored 70+ PhDs. His visionary research in ceramics, glasses and composites has helped shape modern biomaterials science.

Many congratulations – such a well-deserved honor!

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Exploring Brain Mechanics @ebmresearch.bsky.social · 20d

We are proud to announce that our PI, Prof. Aldo R. Boccaccini, has received the prestigious George Winter Award from the European Society for Biomaterials (ESB), honoring pioneers whose work has made lasting contributions to biomaterials.

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Exploring Brain Mechanics @ebmresearch.bsky.social · 24d

Want to stay updated on future talks? Sign up for our mailing list for regular invitations and Zoom links: lists.fau.de/cgi-bin/list... (unsubscribe anytime).

crc1540-virtualbraintalks Infoseite

lists.fau.de

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Exploring Brain Mechanics @ebmresearch.bsky.social · 24d

📩 To receive the Zoom link, contact EBM coordinator Andrea Dakkouri-Baldauf at [email protected].

Join us on the translational journey in neurosurgery and discover how research shapes patient care!

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Exploring Brain Mechanics @ebmresearch.bsky.social · 24d

Upcoming EBM Virtual Brain Talk 🧠

We are excited to announce our next virtual brain talk:
"There and back again - The translational journey in modern Neurosurgery"

Speaker: Prof. Dr.med. Oliver Schnell (UKER, Germany)
📅 22.09.2025
⏰ 4:00 PM (CEST)
💻 Online via Zoom

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Exploring Brain Mechanics @ebmresearch.bsky.social · 27d

Using our recently developed "Mean Zero Artificial Diffusion" approach, we have successfully captured the behavior of aggregate formation and obtained an equilibrium state consistent with experimental observations.

Exploring Brain Mechanics @ebmresearch.bsky.social · 27d

In our project C01, we proposed a nonlinear continuum mechanics framework to model the physics of cellular aggregate formation.

Exploring Brain Mechanics @ebmresearch.bsky.social · Sep 5

Collaborative work involving several projects in the consortium has already established the composition of the extracellular matrix as a determinant of the mechanical properties of spinal cord lesions.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Sep 5

Using genetic manipulations, project B05 investigates a link between the mechanical and biochemical properties of spinal cord lesions and axon regeneration in zebrafish.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 29

We want to find out how astrocytes sense mechanical changes of spinal cord tissue and how this influences disease progression in this mouse model of MS.

Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 29

In project B04, we study the impact of mechanobiology on the pathology of multiple sclerosis (MS). The mechanosensory ion channel Piezo1 (red) is upregulated on astrocytes (green) in a mouse model of MS.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 25

This is achieved through the combined application of Brillouin microscopy and atomic force microscopy (AFM)-enabled indentation measurements.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 25

B03 aims to investigate the mechanical phenotype of the central nervous system (CNS) at the cellular and tissue-wide levels following targeted manipulations, utilizing in vivo and in vitro models.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 15

B02 focuses on understanding the mechanical properties of the spinal cord in Xenopus laevis using advanced techniques such as atomic force microscopy (AFM) and Brillouin microscopy.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 8

Thereby, we addressed the long-standing problem of inconsistent mechanical responses when characterizing brain tissue with different experimental techniques. Read here: doi.org/10.1016/j.jm...

Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 8

By combining the mechanical responses in a hyper-viscoelastic model, we demonstrate that the frequency-dependent behavior can be inferred from the material's time response.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 8

🧠 A new exciting paper from our EBM scientists: In this study, a brain phantom material was characterized in the time domain using a rheometer in the mid-frequency range at a vibration table and in the high-frequency range with tabletop magnetic resonance elastography.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 1

The microscopy image was created in collaboration with Nora John from the research group of Daniel Wehner (B05).

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 1

To this end, we use the morphological changes of zebrafish spinal cord tissue during post-injury remodeling as a bridge to connect the mechanical stimuli of the regeneration-promoting processes with growth modeling and simulation based on the Finite Element Method.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Aug 1

Project B01 aims to understand the complex mechanical signature of spinal cord tissue before and after injury to develop continuum models that simulate the process of successful regeneration.

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Exploring Brain Mechanics @ebmresearch.bsky.social · Jul 25

In vivo model to study the mechanics of developmental brain disorders: Project A05 investigates how specific somatic mutations affect the mechanical properties of developing brain tissue.

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